Polysaccharide-based aerogels—Promising biodegradable carriers for drug delivery systems

García‐González, Carlos A.; Alnaief, Mohammad; Смирнова, Ирина

doi:10.1016/j.carbpol.2011.06.066

Cited by 646 publications

(456 citation statements)

References 105 publications

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“…Particularmente, aerogéis feitos de materiais renováveis constituem uma interessante classe de adsorventes por apresentar uma combinação de baixa densidade, área superficial significativa e resiliência (GARCÍA-GONZÁLEZ et al, 2011). Isso explica o fato de que, independentemente de sua proporção CNF:Xilana, todos os aerogéis testados apresentaram poder de adsorção para o pitch.…”

Section: Quadro 1 -Resultados Das Contagens De Micelas De Pitch Coloiunclassified

Aplicação De Aerogéis Para Remoção De Pitch Na Indústria De Celulose E Papel

Silva¹,

Rodrigues²,

Oliveira³

2017

The Journal of Engineering and Exact Sciences

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Section: Quadro 1 -Resultados Das Contagens De Micelas De Pitch Coloiunclassified

Aplicação De Aerogéis Para Remoção De Pitch Na Indústria De Celulose E Papel

Silva¹,

Rodrigues²,

Oliveira³

2017

The Journal of Engineering and Exact Sciences

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“…Microencapsulation is intended to improve efficacy, reduce adverse events, improve compliance, and make the product more convenient to patients. Aerogels are nanoporous materials that have large and highlyporous surface areas that can entrap agents in such a way as to better modulate their release [131]. Drug-loaded beads may be produced using a microencapsulation technique known as prilling, in which a nozzle is used to separate a laminar jet of polymer solution into drops which are immediately brought into contact with a gelling solution, creating uniform-sized hydrated beads [132].…”

Section: Novel Nsaid Preparationsmentioning

confidence: 99%

Acute Pain Management in the Emergency Department: Emphasis on NSAIDs

Nalamachu¹

2014

Emergency Medicine

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“…They are mostly amorphous and are usually prepared using sol-gel technology. The solvent is eliminated using a special drying technique such as supercritical fluid (SCF) technology to maintain the structure of the gel and to prevent the pore collapse phenomenon by protecting the dried product against cracking and shrinkage [7][8][9][10]. SCF has been used as a drying system to prepare chitin aerogels from chitin alcogels [11].…”

Section: Introductionmentioning

confidence: 99%

Drying Using Supercritical Fluid Technology as a Potential Method for Preparation of Chitosan Aerogel Microparticles

et al. 2015

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Abstract. Supercritical fluid technology offers several advantages in preparation of microparticles. These include uniformity in particle size, morphology, and drug distribution without degradation of the product. One of the recent advantages is preparation of porous aerogel carrier with proper aerodynamic properties. In this study, we aimed to prepare chitosan aerogel microparticles using supercritical fluid (SCF) technology and compare that with microparticles produced by freeze drying (FD). Loading the prepared carriers with a model drug (salbutamol) was also performed. Comparisons of the particle properties and physicochemical characterizations were undertaken by evaluating particle size, density, specific surface area, and porosity. In vitro drug release studies were also investigated. The effect of many variables, such as molecular weight of chitosan oligomers, concentrations of chitosan, and concentrations of tripolyphosphate on the release, were also investigated. Chitosan aerogels were efficiently produced by SCF technology with an average particle size of 10 μm with a tapped density values around 0.12 g/mL, specific surface area (73-103)m 2 /g, and porosity (0.20-0.29)cc/g. Whereas, microparticles produced by FD method were characterized as cryogels with larger particle size (64 microns) with clear cracking at the surface. Sustained release profile was achieved for all prepared microparticles of salbutamol produced by the aforementioned methods as compared with pure drug. The results also demonstrates that chitosan molecular weight, polymer concentration, and tripolyphosphate concentration affected the release profile of salbutamol from the prepared microparticles. In conclusion, SCF technology was able to produce chitosan aerogel microparticles loaded with salbutamol that could be suitable for pulmonary drug delivery system.

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Polysaccharide-based aerogels—Promising biodegradable carriers for drug delivery systems

Cited by 646 publications

References 105 publications

Aplicação De Aerogéis Para Remoção De Pitch Na Indústria De Celulose E Papel

Aplicação De Aerogéis Para Remoção De Pitch Na Indústria De Celulose E Papel

Acute Pain Management in the Emergency Department: Emphasis on NSAIDs

Drying Using Supercritical Fluid Technology as a Potential Method for Preparation of Chitosan Aerogel Microparticles

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