Polysaccharide-Based Hydrogels as Biomaterials

Aminabhavi, Tejraj M.; Deshmukh, Anand S.

doi:10.1007/978-3-319-25322-0_3

Cited by 23 publications

(9 citation statements)

References 131 publications

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“…The FTIR spectrum has also proven the methacrylation of Kefiran by the appearance of the carbon double bond peak at 1717 cm −1 , identified in methacrylate groups but not in the unmodified Kefiran polysaccharide (Figure 2). The use of polysaccharides for TERM is dependent on their biological and physical properties; also, the presence of reactive chemical functional groups make polysaccharides easily flexible to physical and chemical cross-linking, which turn them ideal biomaterials for tissue engineering applications [22]. As previously demonstrated, the molecular structure and component dynamics of materials were studied by NMR and FTIR.…”

Section: Ftirmentioning

confidence: 98%

Synthesis and Characterization of Biocompatible Methacrylated Kefiran Hydrogels: Towards Tissue Engineering Applications

et al. 2021

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Hydrogel application feasibility is still limited mainly due to their low mechanical strength and fragile nature. Therefore, several physical and chemical cross-linking modifications are being used to improve their properties. In this research, methacrylated Kefiran was synthesized by reacting Kefiran with methacrylic anhydride (MA). The developed MA-Kefiran was physicochemically characterized, and its biological properties evaluated by different techniques. Chemical modification of MA-Kefiran was confirmed by 1H-NMR and FTIR and GPC-SEC showed an average Mw of 793 kDa (PDI 1.3). The mechanical data obtained revealed MA-Kefiran to be a pseudoplastic fluid with an extrusion force of 11.21 ± 2.87 N. Moreover, MA-Kefiran 3D cryogels were successfully developed and fully characterized. Through micro-CT and SEM, the scaffolds revealed high porosity (85.53 ± 0.15%) and pore size (33.67 ± 3.13 μm), thick pore walls (11.92 ± 0.44 μm) and a homogeneous structure. Finally, MA-Kefiran revealed to be biocompatible by presenting no hemolytic activity and an improved cellular function of L929 cells observed through the AlamarBlue® assay. By incorporating methacrylate groups in the Kefiran polysaccharide chain, a MA-Kefiran product was developed with remarkable physical, mechanical, and biological properties, resulting in a promising hydrogel to be used in tissue engineering and regenerative medicine applications.

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Section: Ftirmentioning

confidence: 98%

Synthesis and Characterization of Biocompatible Methacrylated Kefiran Hydrogels: Towards Tissue Engineering Applications

et al. 2021

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“…It is one of the most available biomaterials, derived from brown and bacteria and located in the intercellular matrix as a gel containing salts like sodium, calcium, magnesium, strontium, and barium. Alginate is widely used in biomedicine and personal care because of its interesting abilities like gelling property, viscous nature, stabilizing properties, and high water absorption . There are some researches about using alginate‐based superabsorbent for various hygienic and medical applications.…”

Section: Natural Superabsorbents: Benefits and Limitationsmentioning

confidence: 99%

“…The presence of sulfate groups in CG and its chemical affinity to mammalian glycosaminoglycan are the most important factors determining properties such as antiviral, anticoagulant, antioxidant, and anticancer activities. Carrageenan hydrogels are widely used in drug delivery, immobilization of enzymes, and various types of pharmaceuticals . For example, Hosseinzadeh proposed a new full‐polysaccharide superabsorbent hydrogel via chemical cross‐linking of CG and sodium alginate (Alg) using epichlorohydrin as a cross‐linker.…”

Section: Natural Superabsorbents: Benefits and Limitationsmentioning

confidence: 99%

Cellulose‐based hydrogels for personal care products

Bashari

Shirvan

Shakeri

2018

Polymers for Advanced Techs

143

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Name of cellulose is referred to a type of natural carbohydrate with many hydroxyl groups and high water absorption capacity. Cellulose is the most abundant natural polymer, found as the main constituent of plants (plant cellulose). Some bacteria such as Acetobacter xylinum are also able to synthesize bacterial cellulose. Cellulose-based hydrogels are superabsorbent materials, which make 3D networks. Chemical bonds or other cohesive forces such as hydrogen bonding or ionic interactions connect the cellulose chains together. Hydrogels can swell and absorb water and other aqueous fluids in their 3D networks, but they are insoluble in them. Nowadays, an increasing demand emerges for biodegradable materials and products made from renewable resources such as cellulose. The excellent biocompatibility of cellulose has prompted the large use of cellulose-based personal care products. Cellulose hydrogel is used for these products as the thickener and stabilizing agents or as moisturizing agent to improve the skin feel of the product. Hygienic cellulosic absorbent products such as diapers, panty liners, tampons, paper towels, and tissue papers are used as personal care products. These products are available in different absorbency ratings from junior to ultra-absorbency. Using cellulose-based hydrogel, superabsorbent products are made. In this review, applications of cellulose-based hydrogels in personal care products were reviewed.

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“…Polysaccharide-based physical hydrogels can be classified according to various criteria [8,74,75,76], such as the source of the precursors, polymer composition, polymer configuration, type of cross-linking, and so on. In this mini-review, attention is made on the polymer composition as a basis to classify polysaccharide hydrogels.…”

Section: The Structure Of Supramolecular Hydrogelsmentioning

confidence: 99%

Physicochemical Properties and the Gelation Process of Supramolecular Hydrogels: A Review

Karoyo

Wilson

2017

Gels

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Supramolecular polysaccharide-based hydrogels have attracted considerable research interest recently due to their high structural functionality, low toxicity, and potential applications in foods, cosmetics, catalysis, drug delivery, tissue engineering and the environment. Modulation of the stability of hydrogels is of paramount importance, especially in the case of stimuli-responsive systems. This review will update the recent progress related to the rational design of supramolecular hydrogels with the objective of understanding the gelation process and improving their physical gelation properties for tailored applications. Emphasis will be given to supramolecular host-guest systems with reference to conventional gels in describing general aspects of gel formation. A brief account of the structural characterization of various supramolecular hydrogels is also provided in order to gain a better understanding of the design of such materials relevant to the nature of the intermolecular interactions, thermodynamic properties of the gelation process, and the critical concentration values of the precursors and the solvent components. This mini-review contributes to greater knowledge of the rational design of supramolecular hydrogels with tailored applications in diverse fields ranging from the environment to biomedicine.

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Polysaccharide-Based Hydrogels as Biomaterials

Cited by 23 publications

References 131 publications

Synthesis and Characterization of Biocompatible Methacrylated Kefiran Hydrogels: Towards Tissue Engineering Applications

Synthesis and Characterization of Biocompatible Methacrylated Kefiran Hydrogels: Towards Tissue Engineering Applications

Cellulose‐based hydrogels for personal care products

Physicochemical Properties and the Gelation Process of Supramolecular Hydrogels: A Review

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