Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications

Maiz–Fernández, Sheila; Pérez‐Álvarez, Leyre; Ruiz‐Rubio, Leire; Vilas, José Luis; Lanceros‐Méndez, S.

doi:10.3390/polym12102261

Cited by 41 publications

(20 citation statements)

References 138 publications

(186 reference statements)

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“…Hyaluronic acid (HyA) is a natural linear polysaccharide, being naturally present and abundant in all biologic fluids of some bacteria and all vertebrates [ 2 , 3 , 4 ]. Due to its biocompatibility, biodegradability and presence in the native extracellular matrix of tissues [ 5 ], HyA has been extensively applied for medical [ 6 , 7 ] and biomedical applications [ 8 , 9 ], including drug delivery [ 10 , 11 , 12 ], bioprinting [ 13 ] and tissue engineering [ 14 ], cosmetics [ 15 ] and wastewater treatment [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Hofmeister Ions on Transport Properties of Aqueous Solutions of Sodium Hyaluronate

Musilová

Mráček

Kašpárková

et al. 2021

IJMS

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Tracer diffusion coefficients obtained from the Taylor dispersion technique at 25.0 °C were measured to study the influence of sodium, ammonium and magnesium salts at 0.01 and 0.1 mol dm−3 on the transport behavior of sodium hyaluronate (NaHy, 0.1%). The selection of these salts was based on their position in Hofmeister series, which describe the specific influence of different ions (cations and anions) on some physicochemical properties of a system that can be interpreted as a salting-in or salting-out effect. In our case, in general, an increase in the ionic strength (i.e., concentrations at 0.01 mol dm−3) led to a significant decrease in the limiting diffusion coefficient of the NaHy 0.1%, indicating, in those circumstances, the presence of salting-in effects. However, the opposite effect (salting-out) was verified with the increase in concentration of some salts, mainly for NH4SCN at 0.1 mol dm−3. In this particular salt, the cation is weakly hydrated and, consequently, its presence does not favor interactions between NaHy and water molecules, promoting, in those circumstances, less resistance to the movement of NaHy and thus to the increase of its diffusion (19%). These data, complemented by viscosity measurements, permit us to have a better understanding about the effect of these salts on the transport behaviour of NaHy.

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Section: Introductionmentioning

confidence: 99%

Effect of Hofmeister Ions on Transport Properties of Aqueous Solutions of Sodium Hyaluronate

Musilová

Mráček

Kašpárková

et al. 2021

IJMS

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“…Interestingly numorous naturally occurring polysaccharides posess self-repair property originated from either physical or chemical interactions. 164 Physical non covalent mechanism involves hydrogen bonding, hydrophobic, host-guest, ionic interactions, metal-ligand coordination, and p-p stacking, diffusion or swelling. 165 Chemical reactions based on 'click chemistry' were majorly reported to introduce self healing nature with reversible chemical bond formation ability.…”

Section: Self Healing Naturementioning

confidence: 99%

Recent Development of Polysaccharide-Derived Hydrogel: Properties, Stimuli-Responsiveness and Bioapplications

Mukherjee

2022

Preprint

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Hydrogels are three-dimensional, hydrophilic, polymeric frameworks, constructed through diverse physical or chemical crosslinks. Recent research focuses on their physiological stimuli sensitivity enhancing bioapplications. Biopolymers with responsiveness to local environment like temperature, pH etc. form the foundation in this regard, around which all major natural processes are circulated. Polysaccharides, being most the abundant biopolymers and essential constituent of our daily food like cereals and fruits, are readily available in nature. Hence, among numerous biomacromolecules, polysaccharides are extensively used to prepare hydrogel recently. However, incorporation of certain properties to these gels through derivatization can trigger stimuli responsiveness suitable for various applications especially in biomedical field inspired from the mother nature. For example, in situ cross-linking ability may deliver an intermediate platform between solid scaffolds and saline injections through reversible or irreversible sol-gel transition. Easy injectability provides patient’s relief through reducing recovery time and inflectional hazards. Self recovery of gel within body results automatic inflammation and damage recovery of tissues. This review provides a detail impression on the synthesis of natural polysaccharide derived hydrogel network with structural classification to bulk, supramolecular, micro and nano gel. Several properties important from biomedical point such as in situ, injectable, self healing nature of these hydrogels and various physical, chemical, or biochemical stimuli-responsive characteristics are discussed further. Lastly, their major bioapplications are highlighted.

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“…Self-healing in hydrogels are prepared via dynamic covalent reactions (chemical crosslinking) and/or non-covalent reactions (physical crosslinking) [ 23 ] shown in Figure 6 . In covalent reactions, the re-use of polymerization conditions or the utilization of an external stimulus (e.g., heat [ 148 ], pH [ 170 ], UV, visible light [ 171 ]) is necessary for the completion of the healing process. In contrast, autonomous self-healing generally occurs in materials without using an external stimulus and leads to partial or full recovery of their physicochemical characteristics (e.g., mechanical properties).…”

Section: Self-healing Hydrogel In Cartilage Tissue Engineeringmentioning

confidence: 99%

Advanced Hydrogels for Cartilage Tissue Engineering: Recent Progress and Future Directions

et al. 2021

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Cartilage is a tension- and load-bearing tissue and has a limited capacity for intrinsic self-healing. While microfracture and arthroplasty are the conventional methods for cartilage repair, these methods are unable to completely heal the damaged tissue. The need to overcome the restrictions of these therapies for cartilage regeneration has expanded the field of cartilage tissue engineering (CTE), in which novel engineering and biological approaches are introduced to accelerate the development of new biomimetic cartilage to replace the injured tissue. Until now, a wide range of hydrogels and cell sources have been employed for CTE to either recapitulate microenvironmental cues during a new tissue growth or to compel the recovery of cartilaginous structures via manipulating biochemical and biomechanical properties of the original tissue. Towards modifying current cartilage treatments, advanced hydrogels have been designed and synthesized in recent years to improve network crosslinking and self-recovery of implanted scaffolds after damage in vivo. This review focused on the recent advances in CTE, especially self-healing hydrogels. The article firstly presents the cartilage tissue, its defects, and treatments. Subsequently, introduces CTE and summarizes the polymeric hydrogels and their advances. Furthermore, characterizations, the advantages, and disadvantages of advanced hydrogels such as multi-materials, IPNs, nanomaterials, and supramolecular are discussed. Afterward, the self-healing hydrogels in CTE, mechanisms, and the physical and chemical methods for the synthesis of such hydrogels for improving the reformation of CTE are introduced. The article then briefly describes the fabrication methods in CTE. Finally, this review presents a conclusion of prevalent challenges and future outlooks for self-healing hydrogels in CTE applications.

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Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications

Cited by 41 publications

References 138 publications

Effect of Hofmeister Ions on Transport Properties of Aqueous Solutions of Sodium Hyaluronate

Effect of Hofmeister Ions on Transport Properties of Aqueous Solutions of Sodium Hyaluronate

Recent Development of Polysaccharide-Derived Hydrogel: Properties, Stimuli-Responsiveness and Bioapplications

Advanced Hydrogels for Cartilage Tissue Engineering: Recent Progress and Future Directions

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