Polysaccharide-Based Membrane Biocompatibility Study of Anacardium occidentale L. and Polyvinyl Alcohol after Subcutaneous Implant in Rats

Abstract

Polymeric membranes are a viable and sustainable option for the biotechnology industry from an economic and environmental point of view. In this study, we evaluated tissue response and tolerance to the implantation of a polymeric membrane prepared with cashew gum polysaccharide (CGP) associated with polyvinyl alcohol (PVA). The objective was to characterize the biocompatibility of the CGP/PVA membrane in vivo. Following the evaluation criteria of the ISO 10993-6 standard, we demonstrated that the CGP/PVA membrane showed moderate tissue reaction, with a non-irritating ISO pattern, a thinner fibrous capsule, and a smaller amount of collagen compared to the positive control group. At 30 and 60 days, the membrane presented a similar amount of mast cells to that observed in the negative control group. The data demonstrate that the CGP/PVA membrane presents biocompatibility in accordance with the ISO 10993-6 standard.

Design of eco‐synthesized nanocomposites (PVA/TiO2) for promising agents in germicidal and photodecomposition behaviors

“…Pure PVA had five distinct peaks in its spectrum. The spectra exhibit a prominent and wide band at 3440 cm −1 , which can be attributed to the vibrating stretching of hydroxyl groups of PVA 13 . The presence of a band at 2930 cm −1 indicates the deformation of the alkyl group's C–H bond 13 .…”

“…The spectra exhibit a prominent and wide band at 3440 cm −1 , which can be attributed to the vibrating stretching of hydroxyl groups of PVA 13 . The presence of a band at 2930 cm −1 indicates the deformation of the alkyl group's C–H bond 13 . The bands seen at 1640 cm −1 are associated with the C‐C group and can be attributed to the hydrogen bonding between the surrounding O‐H group and the nearby molecules 14 .…”

“…13 The presence of a band at 2930 cm À1 indicates the deformation of the alkyl group's C-H bond. 13 The bands seen at 1640 cm À1 are associated with the C-C group and can be attributed to the hydrogen bonding between the surrounding O-H group and the nearby molecules. 14 The presence of a band at 1090 cm À1 indicates the stretching of the C-O bond in the acetyl group found in the PVA molecule.…”

Polissacarídeos Naturais: Anacardium Occidentale L. E Suas Aplicações Na Obtenção De Scaffolds Para Liberação De Fármacos

“…A produção de scaffolds utilizando a espécie Anacardium occidentale L. ainda é exclusivamente com a goma, Chagas et al (2022) Existem várias técnicas de obtenção de scaffolds, entre elas destaca-se a fundição por solvente, lixiviação de sal, liofilização, separação de fases induzida termicamente, eletrofiação, e impressão 3D. Cada técnica resulta em implantes poliméricos com características e funcionalidades diferentes, sendo os principais tipos membrana polimérica, filme fino, hidrogel, dispositivo 3D impresso e convencional (Figura 5), assim a metodologia de produção deve ser escolhida de acordo com as propriedades do polímero e a aplicação final (Calori et al, 2020;Suamte et al, 2023).…”