Polysaccharide-derivative coated intravascular catheters with superior multifunctional performance via simple and biocompatible method

Park, Se Kye; Shin, Jae Hak; Jung, Jae Hee; Lee, Dong Yun; Choi, Dong Yun; Yoo, Seung Hwa

doi:10.1016/j.cej.2022.134565

Cited by 20 publications

(11 citation statements)

References 49 publications

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“…Those PEG-MMMs could form a hydration layer to reduce the bacterial adhesion on the surface. 58,59 The mechanical properties of PEG-MMMs were tested by the stress–strain curve to explore the stability of those membranes under environmental stress (Fig. S26†), and the corresponding tensile parameters including elastic modulus, ultimate tensile strength, and elongation at break are listed in Table S4 †.…”

Section: Resultsmentioning

confidence: 99%

Modulating charge transfer over metal–organic framework nanocomposites for NIR light-boosted photothermal conversion

Liu

Wang

et al. 2022

J. Mater. Chem. A

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Section: Resultsmentioning

confidence: 99%

Modulating charge transfer over metal–organic framework nanocomposites for NIR light-boosted photothermal conversion

Liu

Wang

et al. 2022

J. Mater. Chem. A

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“…developed a stable multilayer film composed of albumin and heparin, which showed antithrombotic ability by inhibiting platelet adhesion by improving the elasticity of the multilayer film. Se Kye Park et al 16 . reported a novel strategy to modify the internal surface of vascular scaffolds using a multifunctional polysaccharide, O‐carboxymethyl chitosan (CMC).…”

Section: Introductionmentioning

confidence: 99%

“…[12][13][14] Kengo Manabe et al 15 developed a stable multilayer film composed of albumin and heparin, which showed antithrombotic ability by inhibiting platelet adhesion by improving the elasticity of the multilayer film. Se Kye Park et al 16 reported a novel strategy to modify the internal surface of vascular scaffolds using a multifunctional polysaccharide, O-carboxymethyl chitosan (CMC). The antifouling properties of the surface reflect the excellent anti-E. coli and platelet adhesion as well as the inherent multifunction of CMC.…”

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confidence: 99%

Design and preparation of an artificial vascular scaffold with internal surface modification

Jin,

Liu,

Nie

et al. 2024

Artificial Organs

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BackgroundAdvances in regeneration methods have brought us improved vascular scaffolds with small diameters (φ < 6 mm) for enhancing biological suitability that solve their propensity for causing intimal hyperplasia post‐transplantation.MethodsThe correlation between the rehydration ratio of the hydrogel and its material concentration is obtained by adjusting the material ratio of the hydrogel solution. The vascular model with helical structure has been established and analyzed to verify the effect of helical microvascular structure on thrombosis formation by the fluid simulation methods. Then, the helical structure vascular has been fabricated by self‐developed 3D bioprinter, the vascular scaffolds are freeze‐dried and rehydrated in polyethylene glycol (PEG) solution.ResultsThe experimental results showed that the hybrid hydrogel had a qualified rehydration ratio when the content of gelatin, sodium alginate, and glycerol was 5, 6, and 3 wt%. The established flow channel model can effectively reduce thrombus deposition and improve long‐term patency ratio. After PEG solution modification, the contact angle of the inner wall of the vascular scaffold was less than 30°, showing better hydrophilic characteristics.ConclusionIn study, a small‐diameter inner wall vascular scaffold with better long‐term patency was successfully designed and prepared by wrinkling and PEG modification of the inner wall of the vascular scaffold. This study not only creates small‐diameter vascular scaffolds with helical structure that improves the surface hydrophilicity to reduce the risk of thrombosis but also rekindles confidence in the regeneration of small caliber vascular structures.

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“…13,29,30 However, the widespread application of superhydrophilic coatings is hindered by challenges related to substrate compatibility and coating uniformity, making their production a complex endeavor for the majority of CVCs. 5,31,32 Consequently, the introduction of this straightforward and versatile superhydrophilic coating technique holds the potential to mitigate the coagulation and bacterial infection issues associated with CVCs.…”

Section: Introductionmentioning

confidence: 99%

“…Central venous catheters (CVCs), among other blood-contacting catheters, hold significant importance in the management of cardiovascular disease and cancer. − Typically, materials such as silicone rubber (SR), thermoplastic polyurethane, and polyurethane are employed in the construction of CVCs. ,− These materials are preferred due to their exceptional biocompatibility, resistance to high temperatures, and corrosion resistance. ,− Nevertheless, protein, bacterial, and platelet adhesion in the bloodstream can lead to thrombosis and bacterial infections. ,, These issues mainly arise from the catheter’s inappropriate wettability and the lack of antimicrobial properties. , These challenges can significantly burden patients, potentially leading to treatment failure or even mortality. ,, A common clinical strategy for the treatment of infection and thrombosis is to give antibiotics and intravenous heparin (Hep) immediately before or after catheter implantation, which often faces problems such as the development of resistant organisms and thrombocytopenia due to excess Hep . Consequently, the development of antibacterial and anticoagulant catheters remains a formidable undertaking.…”

Section: Introductionmentioning

confidence: 99%

Generalized Multifunctional Coating Strategies Based on Polyphenol-Amine-Inspired Chemistry and Layer-by-Layer Deposition for Blood Contact Catheters

Du,

Zhang,

et al. 2024

ACS Biomater. Sci. Eng.

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Blood-contacting catheters play a pivotal role in contemporary medical treatments, particularly in the management of cardiovascular diseases. However, these catheters exhibit inappropriate wettability and lack antimicrobial characteristics, which often lead to catheter-related infections and thrombosis. Therefore, there is an urgent need for blood contact catheters with antimicrobial and anticoagulant properties. In this study, we employed tannic acid (TA) and 3-aminopropyltriethoxysilane (APTES) to create a stable hydrophilic coating under mild conditions. Heparin (Hep) and poly(lysine) (PL) were then modified on the TA-APTES coating surface using the layer-by-layer (LBL) technique to create a superhydrophilic TA/APTES/ (LBL) 4 coating on silicone rubber (SR) catheters. Leveraging the superhydrophilic nature of this coating, it can be effectively applied to blood-contacting catheters to impart antibacterial, antiprotein adsorption, and anticoagulant properties. Due to Hep's anticoagulant attributes, the activated partial thromboplastin time and thrombin time tests conducted on SR/TA-APTES/(LBL) 4 catheters revealed remarkable extensions of 276 and 103%, respectively, when compared to uncoated commercial SR catheters. Furthermore, the synergistic interaction between PL and TA serves to enhance the resistance of SR/TA-APTES/(LBL) 4 catheters against bacterial adherence, reducing it by up to 99.9% compared to uncoated commercial SR catheters. Remarkably, the SR/TA-APTES/(LBL) 4 catheter exhibits good biocompatibility with human umbilical vein endothelial cells in culture, positioning it as a promising solution to address the current challenges associated with blood-contact catheters.

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Polysaccharide-derivative coated intravascular catheters with superior multifunctional performance via simple and biocompatible method

Cited by 20 publications

References 49 publications

Modulating charge transfer over metal–organic framework nanocomposites for NIR light-boosted photothermal conversion

Modulating charge transfer over metal–organic framework nanocomposites for NIR light-boosted photothermal conversion

Design and preparation of an artificial vascular scaffold with internal surface modification

Generalized Multifunctional Coating Strategies Based on Polyphenol-Amine-Inspired Chemistry and Layer-by-Layer Deposition for Blood Contact Catheters

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