Polysaccharide extracted from Althaea officinalis L. root: New studies of structural, rheological and antioxidant properties

Karimi, Shafagh; Ghanbarzadeh, Babak; Roufegarinejad, Leila; Falcone, Pasquale Massimiliano

doi:10.1016/j.carres.2021.108438

Cited by 22 publications

(15 citation statements)

References 71 publications

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“…The maximum absorption (λ max ) changes of BJP-4 and Congo red complex were shown in Figure 1 E. No red shift in λ max of the complex was observed in Congo red solution as blank control, indicating that there was no triple helix structure in BJP-4, which was consistent with the results of CD. This phenomenon was in accordance with the previous research [ 30 ]. Numerous studies have shown that the triple helix structure and MW of polysaccharides significantly affect their pharmacological activity.…”

Section: Resultssupporting

confidence: 94%

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An Acidic Polysaccharide with Anti-Inflammatory Effects from Blackened Jujube: Conformation and Rheological Properties

Liu

Wang

Zhang

2022

Foods

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An acidic polysaccharide fraction (BJP-4) was isolated from blackened jujube, and its advanced structures and anti-inflammatory activity were investigated. X-ray diffraction showed that BJP-4 exhibits both crystalline and amorphous portions. Atomic force microscopy data suggested that it contains a large number of spherical lumps. Circular dichroism and Congo red experiments revealed that it has no triple-helix conformation. In steady shear flow results, the BJP-4 solution was a pseudoplastic non-Newtonian fluid with acid-base stability. BJP-4 (20 mg/mL) showed liquid-like properties (G″ > G′), while it performed weak gel-like behavior at a high concentration (40 mg/mL) (G′ > G″). The anti-inflammatory effects of BJP-4 were further evaluated through in vitro experiments. BJP-4 could down-regulate the over-secretion of inflammatory factors (NO, IL-6, IL-1β, TNF-α, iNOS and COX-2) in RAW264.7 cells due to LPS stimulation. Moreover, it demonstrated that BJP-4 restrained the NF-κB signal pathway by regulating TLR4 expression, reducing IκBα phosphorylation level and NF-κB p65 nuclear translocation. In summary, this present study contributes to the application of blackened jujube polysaccharides in the foods and medicine field.

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Section: Resultssupporting

confidence: 94%

“…In summary, it indicated that BJP-4 exists in both a partially crystalline structure and amorphous fraction. This result was the same as previously reported for Althaea officinalis L. root [ 30 ]. AFM is commonly applied to observe the morphological characteristics of biological substances.…”

Section: Resultssupporting

confidence: 93%

An Acidic Polysaccharide with Anti-Inflammatory Effects from Blackened Jujube: Conformation and Rheological Properties

Liu

Wang

Zhang

2022

Foods

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“…Two bands at 1616 and 1418 cm −1 were attributed to asymmetric and symmetric stretching vibrations of C=O in uronic acid, respectively (Rudtanatip et al, 2022). Furthermore, three peaks at 1157, 1099, and 1016 cm −1 indicated that OCP‐3 had a pyranose ring, and two bands at 952 and 896 cm −1 were assigned to β ‐glycosidic and α ‐glycosidic respectively (Karimi et al, 2021; Shen et al, 2022). These results suggested OCP‐3 was an acidic polysaccharide.…”

Section: Resultsmentioning

confidence: 99%

An acidic polysaccharide from Oxalis corniculata L. and the preliminary study on its antioxidant activity

Gao

Zhang

et al. 2022

Journal of Food Biochemistry

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It has been reported that the aqueous extract from Oxalis corniculate has excellent pharmacological effects, but its polysaccharide as the major ingredient in the aqueous extract has not been reported. When the temperature of 50°C, ultrasonic power of 270 W, time of 25 min, solid to liquid ratio of 30 ml•g −1 , the optimal O. corniculate polysaccharide (OCP) yield was 9.45%. The physicochemical properties indicated that OCP-3, as the major fraction of OCP, was an acidic polysaccharide with 31.5 kDa, and it mainly consisted of arabinose (47.83%), galacturonic acid (17.81%), and galactose (14.25%). In addition, OCP-3 displayed an excellent antioxidant activity in vitro, including scavenging free radical, anti-lipid peroxidation, and protecting plasmid DNA from oxidative damage. Meanwhile, OCP-3 significantly reduced the levels of malondialdehyde and protein carbonyl by significantly increasing the activity of superoxide dismutase, catalase, and glutathione peroxidase, which protected the HEK 293 cell and Caenorhabditis elegans from oxidative damage. All the results suggested that OCP-3 might be the major active ingredient of the aqueous extract from O. corniculate, and OCP-3 might be a potent antioxidant supplement in the food, cosmetics, and medical industries. Practical ApplicationsOxalis corniculate is a kind of wild vegetable and ethnomedicine, and it is widely distributed in temperate zones. Unfortunately, its utilization rate is low compared to its yield.

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“…Herbalism is an ancient practice that has been used by many cultures throughout history.. 1 Numerous studies have shown that Althaeaofficinalis is effective in promoting healing of ulcers 2 . Hemorrhoids refer to the presence of varicose veins in the anorectal region of the gastrointestinal tract.…”

Section: Introductionmentioning

confidence: 99%

Competence of Althaeaofficinalis Seed Extract in control of Haemorrhoids in comparison with Daflon

Ahmad¹,

Anwar²,

Chaudhary³

et al. 2023

PJMHS

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Background: The use of medicinal plants in herbalism has been documented for thousands of years, with evidence dating back to ancient civilizations such as the, Chinese, Greeks and Egyptians1. Extensive clinical studies have demonstrated that Althaeaofficinalis has properties that promote healing of ulcers2. Aim: To evaluate effectiveness of Althaeaofficinalis seed extract compared to Daflon (diosmin plus hesperidin) in treating hemorrhoids. Methods: A double-blind, randomized clinical trial was carried out in Lahore's urban community. Patients with acute hemorrhoids were randomly divided into two parallel groups, each with 60 participants, for a one-week period. The selection of family physicians for the study was done randomly.6,7,8 Interventions: In the beginning, the participants were given either two capsules of 500mg Althaea seed extract or two tablets of Daflonin morning and evening for four days, followed by two capsules/tablets daily for the next three days. The primary measure of effectiveness was the alleviation of symptoms and signs.9,10 Results: Both groups demonstrated similar improvement from first day tolast day. The intensity of symptoms such as itching, tenesmus, and bleeding ,swelling, painetc reduced markedly in both groups, but the reduction was fast in the Althaeaofficinalis seed extract group observed initial days of the trial. Practical Implications: Estimated prevalence of haemorrhoids ranges from 2.9% to 27.9% worldwide.11,12.13 However, due to cultural practices, it is often ignored and left untreated, It is therefore essential to design preventive measures and control strategies for hemorrhoids. Conclusion: Both Althaea and Daflon were found relieving haemorrhoidal signs and symptoms of hemorrhoids. However, the use of Althaea seed extract resulted in quicker relief and it may be used as good alternative to Daflon. Keywords: Haemorrhoids ,Altthaea seed extract, Althaeaofficinalis, double blind, tenesmus, bleeding,

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Polysaccharide extracted from Althaea officinalis L. root: New studies of structural, rheological and antioxidant properties

Cited by 22 publications

References 71 publications

An Acidic Polysaccharide with Anti-Inflammatory Effects from Blackened Jujube: Conformation and Rheological Properties

An Acidic Polysaccharide with Anti-Inflammatory Effects from Blackened Jujube: Conformation and Rheological Properties

An acidic polysaccharide from Oxalis corniculata L. and the preliminary study on its antioxidant activity

Competence of Althaeaofficinalis Seed Extract in control of Haemorrhoids in comparison with Daflon

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