Polysaccharide from<i>Pleurotus tuber-regium</i>mycelium improves DSS-induced colitis in mice by regulating inflammatory cytokines, oxidative stress and gut microbiota

Mo, Cuiyuan; Liu, Ruofan; Yang, Zhenhua; Ma, Aimin

doi:10.1039/d3fo05583c

Food Funct.

2024

DOI: 10.1039/d3fo05583c

|View full text |Cite

Polysaccharide fromPleurotus tuber-regiummycelium improves DSS-induced colitis in mice by regulating inflammatory cytokines, oxidative stress and gut microbiota

Cuiyuan Mo,

Ruofan Liu,

Zhenhua Yang

et al.

Abstract: Pleurotus tuber-regium (PTR) has been proved to have obvious pharmacological values. In this study, the polysaccharide was extracted from mycelium of PTR and treated DSS-induced colitis mice to clarify the...

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The probiotic Lactobacillus plantarum alleviates colitis by modulating gut microflora to activate PPARγ and inhibit MAPKs/NF-κB

Zang,

Zhou,

et al. 2024

Eur J Nutr

View full text Add to dashboard Cite

The probiotic Lactobacillus plantarum alleviates colitis by modulating gut microflora to activate PPARγ and inhibit MAPKs/NF-κB

Zang,

Zhou,

et al. 2024

Eur J Nutr

View full text Add to dashboard Cite

Effects of traditional Chinese medicine polysaccharides on chronic diseases by modulating gut microbiota: A review

Li,

Zhu,

Liu

et al. 2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Lactobacillus rhamnosus 1.0320 Postbiotics Ameliorate Dextran Sodium Sulfate-Induced Colonic Inflammation and Oxidative Stress by Regulating the Intestinal Barrier and Gut Microbiota

Zhang,

Duan,

Chen

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

Probiotics are increasingly being used as an adjunctive therapy for ulcerative colitis. However, some safety issues have been found in the clinical use of probiotics. Postbiotics have attracted much attention due to their storage stability, safety, and potential functions, but the dose required to exert a significant protective effect is unknown. Therefore, this study evaluated the potential mechanisms of different doses (200, 400, 600 mg/kg) of Lactobacillus rhamnosus 1.0320 postbiotics (1.0320P) in alleviating dextran sodium sulfate (DSS)-induced colitis. The study revealed that 1.0320P could mitigate DSS-induced colitis with signs of reductions in the disease activity index, amelioration of colon tissue damage, decreased secretion of proinflammatory cytokines, reduced oxidative stress levels, and lower bone marrow peroxidase activity. Furthermore, high dose of 1.0320P could upregulated the expression of key proteins in the Nrf2/ARE pathway (NQO1, Nrf2, and HO-1) and downregulated the expression of key proteins in the TLR4/NF-κB signaling pathway (TLR4, MyD88, and NF-κB p65). In addition, high dose of 1.0320P could upregulate the expression of tight junction (TJ) proteins including ZO-1, Occludin, and Claudin-1, contributing to the restoration of the intestinal mucosal barrier function. Additionally, 1.0320P was found to effectively correct imbalances in the intestinal microbiota and enhance the synthesis of short-chain fatty acids (SCFAs), thereby regulating homeostasis in the intestinal internal environment. Overall, our findings suggest that postbiotics could ameliorate colonic inflammation while being somewhat dose-dependent. This study provides new insights into postbiotics as a next-generation biotherapeutic agent for the treatment of ulcerative colitis and even other diseases.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Polysaccharide fromPleurotus tuber-regiummycelium improves DSS-induced colitis in mice by regulating inflammatory cytokines, oxidative stress and gut microbiota

Abstract: Pleurotus tuber-regium (PTR) has been proved to have obvious pharmacological values. In this study, the polysaccharide was extracted from mycelium of PTR and treated DSS-induced colitis mice to clarify the...

Cited by 3 publications

References 44 publications

The probiotic Lactobacillus plantarum alleviates colitis by modulating gut microflora to activate PPARγ and inhibit MAPKs/NF-κB

The probiotic Lactobacillus plantarum alleviates colitis by modulating gut microflora to activate PPARγ and inhibit MAPKs/NF-κB

Effects of traditional Chinese medicine polysaccharides on chronic diseases by modulating gut microbiota: A review

Lactobacillus rhamnosus 1.0320 Postbiotics Ameliorate Dextran Sodium Sulfate-Induced Colonic Inflammation and Oxidative Stress by Regulating the Intestinal Barrier and Gut Microbiota

Contact Info

Product

Resources

About