Polysaccharide from vinegar baked radix bupleuri as efficient solubilizer for water-insoluble drugs of Chinese medicine

Zhao, Yutong; Wan, Peng; Wang, Jinqiu; Li, Ping; Hu, Qiaohong; Zhao, Ruo

doi:10.1016/j.carbpol.2019.115473

Cited by 30 publications

(18 citation statements)

References 35 publications

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“…In recent years, researchers have isolated different kinds of polysaccharides from Bupleurum to explore their structure. The monosaccharide compositions of other Bupleurum polysaccharide analogues were compared with BCP, as shown in Table S3 [ 11 , 12 , 15 , 16 , 42 , 43 , 44 , 45 , 46 ]. The detection of galacturonic acid in BCP was consistent with the previous determination of uronic acid in BCP by the carbazole sulfonic acid method [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

The Structural Characteristics of an Acidic Water-Soluble Polysaccharide from Bupleurum chinense DC and Its In Vivo Anti-Tumor Activity on H22 Tumor-Bearing Mice

et al. 2022

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This study explored the preliminary structural characteristics and in vivo anti-tumor activity of an acidic water-soluble polysaccharide (BCP) separated purified from Bupleurum chinense DC root. The preliminary structural characterization of BCP was established using UV, HPGPC, FT-IR, IC, NMR, SEM, and Congo red. The results showed BCP as an acidic polysaccharide with an average molecular weight of 2.01 × 103 kDa. Furthermore, we showed that BCP consists of rhamnose, arabinose, galactose, glucose, and galacturonic acid (with a molar ratio of 0.063:0.788:0.841:1:0.196) in both α- and β-type configurations. Using the H22 tumor-bearing mouse model, we assessed the anti-tumor activity of BCP in vivo. The results revealed the inhibitory effects of BCP on H22 tumor growth and the protective actions against tissue damage of thymus and spleen in mice. In addition, the JC-1 FITC-AnnexinV/PI staining and cell cycle analysis have collectively shown that BCP is sufficient to induce apoptosis and of H22 hepatocarcinoma cells in a dose-dependent manner. The inhibitory effect of BCP on tumor growth was likely attributable to the S phase arrest. Overall, our study presented significant anti-liver cancer profiles of BCP and its promising therapeutic potential as a safe and effective anti-tumor natural agent.

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Section: Resultsmentioning

confidence: 99%

The Structural Characteristics of an Acidic Water-Soluble Polysaccharide from Bupleurum chinense DC and Its In Vivo Anti-Tumor Activity on H22 Tumor-Bearing Mice

et al. 2022

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“…At the same time, carbohydrates are good hydrogen donors and acceptors, which can interact with other molecules to form supramolecular systems. Zhao [ 67 ] isolated and obtained the acidic branched polysaccharide of vinegar-baked Radix bupleuri . The study found that the polysaccharide not only has high solubility for baicalin and rhein, much better than that of Tween 80, but also significantly increased the blood concentrations of baicalin and rhein in vivo.…”

Section: Mechanism Of Formation Of Supramolecules In Traditional Chin...mentioning

confidence: 99%

Study on Supramolecules in Traditional Chinese Medicine Decoction

et al. 2022

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With the application of the concept of supramolecular chemistry to various fields, a large number of supramolecules have been discovered. The chemical components of traditional Chinese medicine have various sources and unique structures. During the high-temperature boiling process, various active components form supramolecules due to complex interactions. The supramolecular structure in a traditional Chinese medicine decoction can not only be used as a drug carrier to promote the absorption and distribution of medicinal components but may also have biological activities superior to those of single active ingredients or their physical mixtures. By summarizing the relevant research results over recent years, this paper introduces the research progress regarding supramolecules in various decoctions, laying a foundation for further research into supramolecules in traditional Chinese medicine decoctions, and provides a new perspective for revealing the compatibility mechanisms of traditional Chinese medicine, guiding clinical medications, and developing new nanometers materials.

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“…With the increase of Chinese herbal polysaccharides in the water extract, the extraction rate of some active water-insoluble compounds increased correspondingly, indicating that polysaccharides might be responsible for it [ 63 ]. Plenty of researches reported that Chinese herbal polysaccharides could significantly enhance the solubilities of small molecule compounds, but the extent of the enhancement varied widely.…”

Section: Enhancement Of Water Solubility Stability and Permeability Of The Drugmentioning

confidence: 99%

“…Its backbone chain was composed of 1,5- α -L-Araf and 1,3,5- α -L-Araf, and the branch chains were 1,5- α -L-Araf, 1,4- β -D-galacturonic acid or 1,2- α -L-Rhap which were linked to the 1,3,5-linked- α -L-Araf backbone at C-3 position. VBCP self-assembled to form micelle-like aggregates in water, which can encapsulate water-insoluble constituents through the interaction of both hydrogen bonding and hydrophobic forces [ 63 ]. Thermodynamic studies showed that van der Waals forces and hydrogen bonds played major roles between the interaction of drug and polysaccharides [ 67 ].…”

Section: Enhancement Of Water Solubility Stability and Permeability Of The Drugmentioning

confidence: 99%

A review on the applications of Traditional Chinese medicine polysaccharides in drug delivery systems

Wang

Xiong

et al. 2022

Chin Med

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Traditional Chinese medicine polysaccharides (TCMPs) are plentiful and renewable resources with properties such as biocompatibility, hydrophilicity, biodegradability, and low cytotoxicity. Because the polysaccharide molecular chain contains a variety of active groups, different polysaccharide derivatives can be easily produced through chemical modification. They have been increasingly used in drug delivery systems (DDS). However, the potential of polysaccharides is usually ignored due to their structural complexity, poor stability or ambiguity of mechanisms of actions. This review summarized the applications of TCMPs in DDS around four main aspects. The general characteristics of TCMPs as drug delivery carriers, as well as the relationships between structure and function of them were summarized. Meanwhile, the direction of preparing multifunctional drug delivery materials with synergistic effect by using TCMPs was discussed. This review aims to become a reference for further research of TCMPs and their derivatives, especially applications of them as carriers in pharmaceutical preparation industry.

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Polysaccharide from vinegar baked radix bupleuri as efficient solubilizer for water-insoluble drugs of Chinese medicine

Cited by 30 publications

References 35 publications

The Structural Characteristics of an Acidic Water-Soluble Polysaccharide from Bupleurum chinense DC and Its In Vivo Anti-Tumor Activity on H22 Tumor-Bearing Mice

The Structural Characteristics of an Acidic Water-Soluble Polysaccharide from Bupleurum chinense DC and Its In Vivo Anti-Tumor Activity on H22 Tumor-Bearing Mice

Study on Supramolecules in Traditional Chinese Medicine Decoction

A review on the applications of Traditional Chinese medicine polysaccharides in drug delivery systems

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