Polysaccharide-K (PSK) in Cancer - Old Story, New Possibilities?

Sun, Chen; Rosendahl, Ann H.; Wang, Xiangdong; Wu, Debo; Andersson, Roland

doi:10.2174/092986712798992020

Cited by 26 publications

(9 citation statements)

References 42 publications

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“…The monosaccharide composition of AIPetinc was determined by Gas Chromatography (GC). For comparison, we also performed parallel experiments on the well-known polysaccharide-protein complex isolated from Trametes versicolor , polysaccharide-K [24]. Table 1 shows that AIPetinc consisted mainly of glucose (88.6%).…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Activity of the Wild Mushroom, Echinodontium tinctorium, in RAW264.7 Macrophage Cells and Mouse Microcirculation

Javed

Zeb

et al. 2019

Molecules

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The aim of this study was to investigate the anti-inflammatory activity of a previously un-studied wild mushroom, Echinodontium tinctorium, collected from the forests of north-central British Columbia. The lipopolysaccharide (LPS)-induced RAW264.7 macrophage model was used to study the in vitro anti-inflammatory activity. The crude alkaline extract demonstrated potent anti-inflammatory activity, and was further purified using a “bio-activity-guided-purification” approach. The size-exclusion and ion-exchange chromatography yielded a water-soluble anti-inflammatory polysaccharide (AIPetinc). AIPetinc has an average molecular weight of 5 kDa, and is a heteroglucan composed of mainly glucose (88.6%) with a small amount of galactose (4.0%), mannose (4.4%), fucose (0.7%), and xylose (2.3%). In in vivo settings, AIPetinc restored the histamine-induced inflammatory event in mouse gluteus maximus muscle, thus confirming its anti-inflammatory activity in an animal model. This study constitutes the first report on the bioactivity of Echinodontium tinctorium, and highlights the potential medicinal benefits of fungi from the wild forests of northern British Columbia. Furthermore, it also reiterates the need to explore natural resources for alternative treatment to modern world diseases.

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Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Activity of the Wild Mushroom, Echinodontium tinctorium, in RAW264.7 Macrophage Cells and Mouse Microcirculation

Javed

Zeb

et al. 2019

Molecules

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“…From the fungi kingdom, polysaccharide-K (PSK, krestin) is one of the most commonly used medicinal mushroom extracts, with a long history in cancer therapy in Asia, especially in Japan [84]. Zhang et al [85] have reported that PSK decreases the invasiveness of a human PC cell line.…”

Section: Phenotypic-target Screening In Pancreatic Cancermentioning

confidence: 99%

Drug Discovery from Natural Products for Pancreatic Cancer

Ramos¹,

Genilloud²,

Reyes³

et al. 2018

Advances in Pancreatic Cancer

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Since ancient times, natural products (NPs) have been used as anti-infectives, anti-inflammatories, antioxidants, analgesics and antitumorals and many compounds derived from NPs are in clinical use. The use of plants in traditional medicine for multiple purposes is well known, and throughout recent history, metabolites of microbial origin have had an extraordinary impact on the welfare of humanity. There is an outstanding diversity of chemical structures that nature, and especially microorganisms, are able to produce, due to millenniums of evolution. Since only a small amount of the world's biodiversity has been evaluated for potential biological activity, many more useful natural lead compounds await discovery, the challenge being how to access this natural chemical diversity. However, the validation and selection of primary screening assays, both phenotypic and target-based, are vital to guaranteeing a selection of extracts or molecules with relevant pharmacological action. The screening of antitumor agents against pancreatic cancer (PC) involves the use of established cell lines, cancer stem cells and spheroids that mimic the patient's tumor. Improvements in the discovery of natural products along with the emergence of new technologies in cancer screening assays, promise the discovery of new and valuable drugs to tackle pancreatic cancer in the coming years.

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“…5A) were round with typical off by inducing their maturation with appropriate "adjuvants". In Asia, PSK is used as an anti-cancer agent for gastric cancer, 9 induction the apoptosis of human leukemia and lymphoma cells, 5 colorectal cancers, 9,10 and small cell lung cancer. 11 PSK has also been reported to resolve the immunosuppressive state of a cancer-bearing host, 12 and might be associated with DC maturation directly.…”

Section: Maturation Of Morphology Phenotype and Functions Of Murine mentioning

confidence: 99%

Maturation of morphology, phenotype and functions of murine bone marrow-derived dendritic cells(DCs) induced by polysaccharide Kureha(PSK)

Tan

Meng²,

Wang

et al. 2012

Human Vaccines & Immunotherapeutics

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The aim of this work was to evaluate the influence of protein-bound polysaccharide Kureha(PSK) on murine dendritic cells (DCs). These impacts of PSK on DCs from bone marrow derived DCs(BMDCs) were assessed with inverted phase contrast microscope, conventional scanning electron microscopy (SEM), transmission electron microscopy (TEM) for morphology, fluorescence activated cell sorting (FACS) analysis, cytochemistry assay for key surface molecules, FITC-dextran for phagocytosis, bio-assay and enzyme linked immunosorbent assay (ELISA) for cytokine production. We found that under the influence of PSK, immature DCs changed into mature DCs with decrease of antigens up-taking, simultaneously high expression of key surface molecules of the MHC classII,CD40, CD80, CD86 and CD83 as well as more production of IL-12p70 and tumor necrosis factor α (TNF-α). These data indicate that PSK could markedly promote maturation of DCs and this adjuvant-like activity may have potential therapeutic value in vaccine preparation.

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Polysaccharide-K (PSK) in Cancer - Old Story, New Possibilities?

Cited by 26 publications

References 42 publications

Anti-Inflammatory Activity of the Wild Mushroom, Echinodontium tinctorium, in RAW264.7 Macrophage Cells and Mouse Microcirculation

Anti-Inflammatory Activity of the Wild Mushroom, Echinodontium tinctorium, in RAW264.7 Macrophage Cells and Mouse Microcirculation

Drug Discovery from Natural Products for Pancreatic Cancer

Maturation of morphology, phenotype and functions of murine bone marrow-derived dendritic cells(DCs) induced by polysaccharide Kureha(PSK)

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