Polysaccharide (laminaran and fucoidan), fucoxanthin and lipids as functional components from brown algae (Padina tetrastromatica) modulates adipogenesis and thermogenesis in diet-induced obesity in C57BL6 mice

Sharma, Priya Prakash; Baskaran, Vallikanan

doi:10.1016/j.algal.2021.102187

Cited by 41 publications

(15 citation statements)

References 57 publications

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“…57 Dietary supplement with 2% brown algae ( Padina tetrastromatica ) polysaccharides decreased the differentiation of adipocytes and down-regulated the expression of p-Akt, p38 and Pparγ in visceral adipose tissue of diet-induced obese C57BL6 mice. 58 A previous study reported that crude fucoidans composed of fucose, glucuronic acid, galactose, xylose, and sulfate exerted antiadipogenic activities, and thus, inhibited the 3T3-L1 cell differentiation. 59 Flaxseed PS fermented by fecal bacteria also exhibited anti-adipogenic effects with a decrease in lipid accumulation in 3T3-L1 cells by downregulation of mRNA and protein expression of Pparγ , C / ebpα , and C / ebpβ in differentiating adipocytes.…”

Section: Discussionmentioning

confidence: 98%

Influence of the ecological environment on the structural characteristics and bioactivities of polysaccharides from alfalfa (Medicago sativa L.)

et al. 2022

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Section: Discussionmentioning

confidence: 98%

Influence of the ecological environment on the structural characteristics and bioactivities of polysaccharides from alfalfa (Medicago sativa L.)

et al. 2022

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“…In a double-blind placebo-controlled study conducted by Hitoe et al [ 15 ], capsules containing 1 and 3 mg fucoxanthin were administered to mildly obese males and females for 4 weeks, resulting in reduced body weight, BMI, and fat area and mass. Fucoxanthin-rich phaeodactylum tricornutum or Padina tetrastromatica extract ameliorated the effects of high diet-induced obesity in c57bl/6j mice by inhibiting adipocytic lipogenesis, inducing fat mass reduction, and decreasing intracellular lipid content, adipocyte size, and adipose weight [ 61 , 62 , 63 ]. Interestingly, fucoxanthin has modulatory effects on gut microbiota to provide anti-obesity effects [ 64 ].…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review on Marine Algae-Derived Fucoxanthin: An Update of Pharmacological Insights

et al. 2022

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Fucoxanthin, belonging to the xanthophyll class of carotenoids, is a natural antioxidant pigment of marine algae, including brown macroalgae and diatoms. It represents 10% of the total carotenoids in nature. The plethora of scientific evidence supports the potential benefits of nutraceutical and pharmaceutical uses of fucoxanthin for boosting human health and disease management. Due to its unique chemical structure and action as a single compound with multi-targets of health effects, it has attracted mounting attention from the scientific community, resulting in an escalated number of scientific publications from January 2017 to February 2022. Fucoxanthin has remained the most popular option for anti-cancer and anti-tumor activity, followed by protection against inflammatory, oxidative stress-related, nervous system, obesity, hepatic, diabetic, kidney, cardiac, skin, respiratory and microbial diseases, in a variety of model systems. Despite much pharmacological evidence from in vitro and in vivo findings, fucoxanthin in clinical research is still not satisfactory, because only one clinical study on obesity management was reported in the last five years. Additionally, pharmacokinetics, safety, toxicity, functional stability, and clinical perspective of fucoxanthin are substantially addressed. Nevertheless, fucoxanthin and its derivatives are shown to be safe, non-toxic, and readily available upon administration. This review will provide pharmacological insights into fucoxanthin, underlying the diverse molecular mechanisms of health benefits. However, it requires more activity-oriented translational research in humans before it can be used as a multi-target drug.

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“…Generally, the lipid fraction of seaweeds represents 1–6% of dry weight (DW) [ 74 , 75 , 76 ]. Despite the low lipid content, seaweeds are considered an important source of polyunsaturated fatty acids (PUFA).…”

Section: Resultsmentioning

confidence: 99%

The Controlled Semi-Solid Fermentation of Seaweeds as a Strategy for Their Stabilization and New Food Applications

Maiorano

Ramires

Durante

et al. 2022

Foods

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For centuries, macroalgae, or seaweeds, have been a significant part of East Asian diets. In Europe, seaweeds are not considered traditional foods, even though they are increasingly popular in Western diets in human food applications. In this study, a biological processing method based on semi-solid fermentation was optimized for the treatment of the seaweed Gracilaria gracilis. For the first time, selected lactic acid bacteria and non-conventional coagulase-negative staphylococci were used as starter preparations for driving a bio-processing and bio-stabilization of raw macroalga material to obtain new seaweed-based food prototypes for human consumption. Definite food safety and process hygiene criteria were identified and successfully applied. The obtained fermented products did not show any presence of pathogenic or spoilage microorganisms, thereby indicating safety and good shelf life. Lactobacillus acidophilus-treated seaweeds revealed higher α-amylase, protease, lipase, endo-cellulase, and endo-xylanase activity than in the untreated sample. This fermented sample showed a balanced n-6/n-3 fatty acid ratio. SBM-11 (Lactobacillus sakei, Staphylococcus carnosus and Staphylococcus xylosus) and PROMIX 1 (Staphylococcus xylosus) treated samples showed fatty acid compositions that were considered of good nutritional quality and contained relevant amounts of isoprenoids (vitamin E and A). All the starters improved the nutritional value of the seaweeds by significantly reducing the insoluble indigestible fractions. Preliminary data were obtained on the cytocompatibility of G. gracilis fermented products by in vitro tests. This approach served as a valid strategy for the easy bio-stabilization of this valuable but perishable food resource and could boost its employment for newly designed seaweed-based food products.

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Polysaccharide (laminaran and fucoidan), fucoxanthin and lipids as functional components from brown algae (Padina tetrastromatica) modulates adipogenesis and thermogenesis in diet-induced obesity in C57BL6 mice

Cited by 41 publications

References 57 publications

Influence of the ecological environment on the structural characteristics and bioactivities of polysaccharides from alfalfa (Medicago sativa L.)

Influence of the ecological environment on the structural characteristics and bioactivities of polysaccharides from alfalfa (Medicago sativa L.)

A Systematic Review on Marine Algae-Derived Fucoxanthin: An Update of Pharmacological Insights

The Controlled Semi-Solid Fermentation of Seaweeds as a Strategy for Their Stabilization and New Food Applications

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