Polysaccharide‐modified synthetic polymeric biomaterials

Baldwin, Aaron D.; Kiick, Kristi L.

doi:10.1002/bip.21334

Cited by 267 publications

(186 citation statements)

References 179 publications

(217 reference statements)

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“…Although both the formation of complexes with macromolecules and coacervates with small inorganic cations are based on ionic interaction, the macromolecular complexes possess additional macromolecular chain physical entanglement properties that are much stronger than other secondary binding mechanisms, such as hydrogen bonding and van der Waals interactions. A group of second polymers, including D-glucono-δ-lactone, polyols, chitosan, and polycationic polymers, have been used to obtain alginate/Ca ++ beads with a more even structure by altering the cross-linking process [8,[12][13][14][15]. Among these polymers, chitosan has gained increased attention as a safe and active component in the preparation of drug delivery systems.…”

Section: Alginate and Alginate/chitosanmentioning

confidence: 99%

Hydrogels from Biopolymer Hybrid for Biomedical, Food, and Functional Food Applications

et al. 2012

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Hybrid hydrogels from biopolymers have been applied for various indications across a wide range of biomedical, pharmaceutical, and functional food industries. In particular, hybrid hydrogels synthesized from two biopolymers have attracted increasing attention. The inclusion of a second biopolymer strengthens the stability of resultant hydrogels and enriches its functionalities by bringing in new functional groups or optimizing the micro-environmental conditions for certain biological and biochemical processes. This article presents approaches that have been used by our groups to synthesize biopolymer hybrid hydrogels for effective uses for immunotherapy, tissue regeneration, food and functional food applications. The research has achieved some challenging results, such as stabilizing physical structure, increasing mucoadhesiveness, and the creation of an artificial extracellular matrix to aid in guiding tissue differentiation.

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Section: Alginate and Alginate/chitosanmentioning

confidence: 99%

Hydrogels from Biopolymer Hybrid for Biomedical, Food, and Functional Food Applications

et al. 2012

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“…It is generally accepted that both synthetic and natural biopolymers could be used in biomaterials research, because of their unique structures that allows for a specific functionalization for desired applications [36]. Moreover, embedding metal and/or metal oxide nanoparticles (NPs) into an organic and/or inorganic matrix could lead to the fabrication of a novel generation of smart biomaterials, with optimized properties [95].…”

Section: Hybrid Dextran-iron Oxide Thin Filmsmentioning

confidence: 99%

“…Its structure consists of linear (1 → 6)-α-D-glucose, with branches extending mainly from (1 → 3) and occasionally from (1 → 4) or (1 → 2) positions accounting for a 5% degree of branching [36]. Due to its specific properties (neutral and watersoluble, easy to functionalize through its reactive hydroxyl groups, biodegradable, biocompatible, long-term stability), it is intensively used in several biomedical applications like an antithrombotic (antiplatelet) to reduce blood viscosity, and as a volume expander in hypovolemia [96].…”

Section: Hybrid Dextran-iron Oxide Thin Filmsmentioning

confidence: 99%

Biopolymer Thin Films Synthesized by Advanced Pulsed Laser Techniques

Axente¹,

Sima²,

Ristoscu³

et al. 2016

Recent Advances in Biopolymers

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This chapter provides an overview of recent advances in the field of laser-based synthesis of biopolymer thin films for biomedical applications. The introduction addresses the importance of biopolymer thin films with respect to several applications like tissue engineering, cell instructive environments, and drug delivery systems. The next section is devoted to applications of the fabrication of organic and hybrid organic-inorganic coatings. Matrix-assisted pulsed laser evaporation (MAPLE) and Combinatorial-MAPLE are introduced and compared with other conventional methods of thin films assembling on solid substrates. Advantages and limitations of the methods are pointed out by focusing on the delicate transfer of bio-macromolecules, preservation of properties and on the prospect of combinatorial libraries' synthesis in a single-step process. The following section provides a brief description of fundamental processes involved in the molecular transfer of delicate materials by MAPLE. Then, the chapter focuses on the laser synthesis of two polysaccharide thin films, namely Dextran doped with iron oxide nanoparticles and Levan, followed by an overview on the MAPLE synthesis of other biopolymers. The chapter ends with summary and perspectives of this fast-expanding research field, and a rich bibliographic database.

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“…In addition, natural polysaccharides, as well as their derivatives, are also attractive pharmaceutical and biomedical materials for better solubility, stability and lower toxicity based on their biodegradability, biocompatibility, and non-immunogenic properties (63,64). It has been demonstrated that oligomannose modification of the asparagine residue of C34, a 34-mer peptide derived from the C-ectodomain of HIV-1 envelope glycoprotein, dramatically improved its solubility and stability as a promising candidate for anti-HIV agents (65,66).…”

Section: Carbohydrates Mediated Drug Modification and Deliverymentioning

confidence: 99%