2020
DOI: 10.5958/0974-360x.2020.00574.0
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Polysaccharide Peptide (PsP) of Ganoderma lucidum as vasa vasorum anti-Angiogenesis agent in Dyslipidemic state by Measuring Lp-PLA2 and H2O2 Levels: In Vivo Study using wistar strain Rattus novergicus model of Atherosclerosis with Dyslipidemia

Abstract: Dyslipidemia is one of risk factors for atherosclerosis induced by high fat diet. In atherosclerosis, an angiogenesis of immature and fragile vasa vasorum leads to atherosclerotic plaque destabilization. Angiogenesis of vasa vasorum is influence by oxidative stress and inflammation. Polysaccharide peptide (PsP) from Ganoderma lucidum (GL) contains bioactive compounds that possess antioxidant and anti-inflammatory properties which might become anti-angiogenesis agent in atherosclerosis. The aim of this study is… Show more

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Cited by 5 publications
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“…Lack of nitric oxide (NO) will cause decreased homeostasis of blood vessels which will lead to endothelial dysfunction (20) . Impaired endothelial function will cause oxidation stress and will later become a factor in the occurrence of cardiovascular disease (21) . This shows a high urgency because if it is not followed up immediately, it is feared that it will increase the level of exposure and the level of disease that is at risk of causing death.…”
Section: Discussionmentioning
confidence: 99%
“…Lack of nitric oxide (NO) will cause decreased homeostasis of blood vessels which will lead to endothelial dysfunction (20) . Impaired endothelial function will cause oxidation stress and will later become a factor in the occurrence of cardiovascular disease (21) . This shows a high urgency because if it is not followed up immediately, it is feared that it will increase the level of exposure and the level of disease that is at risk of causing death.…”
Section: Discussionmentioning
confidence: 99%