Polysaccharide-Rich Extract of <i>Phragmites rhizome</i> Attenuates Water Immersion Stress and Forced Swimming Fatigue in Rodent Animal Model

Chung, Yoon Hee; Park, Tae Kwang; Yim, Sung Hyuk; Lee, Jong Hyuk; Bang, Joon Seok; Shin, Yong Kyoo; Bae, Jinhyung; Sim, Sang Soo; Hwang, Kwang Woo; Shin, Chang Yell; Im, Wi Joon; Khin, Phyu Phyu; Lee, Jaehwi; Min, Young; Jeong, Ji Hoon; Sohn, Uy Dong

doi:10.1089/jmf.2018.4218

Cited by 10 publications

(7 citation statements)

References 52 publications

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“…In one study, luteolin reduced the levels of TBARS and hydroxy radicals against the azoxymethane-induced colon cancer tissues in mice [68]. PEPtreated rats attenuated the increase of myeloperoxidase activity and TBARS level in water immersion stress rats [17]. In the present study, pretreatment with HJE and PEP recovered the TBARS and FRAP values in WAS rats.…”

Section: Discussionsupporting

confidence: 58%

“…e PEP was prepared as reported previously [17]. Briefly, the sliced and dried raw materials of Phragmites rhizoma were blanched at 100 °C for 4 h (43.3 g/L of water) and allowed to cool down to room temperature.…”

Section: Preparation Of Hje and Pepmentioning

confidence: 99%

“…e polysaccharide-rich extract of Phragmites rhizoma (PEP), another medicinal plant belonging to the family of Poaceae, possesses antioxidative, free radical scavenging properties, and anti-inflammatory properties in atopic dermatitis effects [15,16]. In our previous studies, PEP reduced the bleeding and ulcer formation of stomach in forced swimming rats [17]. e dried root of Phragmites rhizoma has been used to alleviate fever and vomiting in traditional Korean medicine.…”

Section: Introductionmentioning

confidence: 99%

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Ameliorative Effects of Humulus japonicus Extract and Polysaccharide-Rich Extract of Phragmites rhizoma in Rats with Gastrointestinal Dysfunctions Induced by Water Avoidance Stress

Thein

Choi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Chronic stress can cause the gastrointestinal disorders characterized by an altered bowel movement and abdominal pain. Studies have shown that Humulus japonicus extract (HJE) has anti-inflammatory and antidiarrheal effects, and Phragmites rhizoma extract (PEP) has antioxidative and antistress effects. The present study aimed to investigate the possible effects of HJE and PEP in rat models with stress-induced gastrointestinal dysfunctions. The rats were exposed to water avoidance stress (WAS, 1 h/day) for 10 days to induce gastrointestinal disorders. We found that WAS significantly increased fecal pellet output during 1 h stress, gastric emptying, colonic contractility, and permeability compared to the normal rats. Pretreatment with HJE and PEP (0.25 and 0.5 mL/kg, both administered separately) improved the increased gastric emptying and colonic contractility induced by electrical field stimulation, acetylcholine, and serotonin and also alleviated the increased colonic permeability. HJE and PEP also increased the claudin-1 and occludin expressions, reduced by WAS. WAS increased the concentration of TNF-α and TBARS and reduced FRAP. HJE and PEP recovered these effects. HJE and PEP improved the gastrointestinal disorders induced by WAS by upregulating the tight junction protein, possibly acting on cholinergic and serotonergic receptors to abolish the colonic hypercontractility and hyperpermeability and degradation of inflammatory cytokines via an antioxidant effect.

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Section: Discussionsupporting

confidence: 58%

Section: Preparation Of Hje and Pepmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ameliorative Effects of Humulus japonicus Extract and Polysaccharide-Rich Extract of Phragmites rhizoma in Rats with Gastrointestinal Dysfunctions Induced by Water Avoidance Stress

Thein

Choi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Generally, fatty acid oxidation can promote the production of ATP energy. Previous studies have also reported mechanisms to achieve anti-fatigue effects by modulating fat-related pathways [ 14 , 75 ].…”

Section: Polysaccharides Ameliorate Fatiguementioning

confidence: 99%

“…Additionally, CK is an important marker of tissue damage and a characteristic response to vigorous exercise. A polysaccharide-rich extract of Phragmites rhizome (PEP) markedly prolongs the swimming endurance capacity of mice, increases glucose levels, and decreases LDH and CK activities [ 75 ]. The water-soluble polysaccharide from Semen cassiae ( Cassia obtusifolia L.) (SCP) exhibited strong anti-fatigue activity in mice; it can extend the weight-loaded swimming duration and decrease the levels of BUN, CK, triglyceride (TG), etc.…”

Section: Polysaccharides Ameliorate Fatiguementioning

confidence: 99%

Dietary Polysaccharides Exert Anti-Fatigue Functions via the Gut-Muscle Axis: Advances and Prospectives

Zhou,

Chu,

Luo

et al. 2023

Foods

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Due to today’s fast-paced lifestyle, most people are in a state of sub-health and face “unexplained fatigue”, which can seriously affect their health, work efficiency, and quality of life. Fatigue is also a common symptom of several serious diseases such as Parkinson’s, Alzheimer’s, cancer, etc. However, the contributing mechanisms are not clear, and there are currently no official recommendations for the treatment of fatigue. Some dietary polysaccharides are often used as health care supplements; these have been reported to have specific anti-fatigue effects, with minor side effects and rich pharmacological activities. Dietary polysaccharides can be activated during food processing or during gastrointestinal transit, exerting unique effects. This review aims to comprehensively summarize and evaluate the latest advances in the biological processes of exercise-induced fatigue, to understand dietary polysaccharides and their possible molecular mechanisms in alleviating exercise-induced fatigue, and to systematically elaborate the roles of gut microbiota and the gut-muscle axis in this process. From the perspective of the gut-muscle axis, investigating the relationship between polysaccharides and fatigue will enhance our understanding of fatigue and may lead to a significant breakthrough regarding the molecular mechanism of fatigue. This paper will provide new perspectives for further research into the use of polysaccharides in food science and food nutrition, which could help develop potential anti-fatigue agents and open up novel therapies for sub-health conditions.

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Polysaccharide Chemistry in Drug Delivery, Endocrinology, and Vaccines

Khalid

Asim-ur-Rehman

Ahmed

et al. 2021

Chemistry A European J

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Polysaccharides, due to their outstanding properties, have attracted the attention of researchers, working in the biomedical field and especially of those working in drug delivery. Modified/functionalized polysaccharides further increase the importance for various applications. Delivery of therapeutics for diverse ailments in different endocrine glands and hormones safely, is a focal point of researchers working in the field. Among the routes followed, the transdermal route is preferred due to non‐exposure of active moieties to the harsh gastric environment and first‐pass metabolism. This review starts with the overview of polysaccharides used for the delivery of various therapeutic agents. Advantages of polysaccharides used in the transdermal route are addressed in detail. Types of polysaccharides will be elaborated through examples, and in this context, special emphasis will be on the polysaccharides being used for synthesis of the membranes/films. Techniques employed for their modification to design novel carriers for therapeutics delivery will also be discussed. The review will end with a brief discussion on recent developments and future perspectives for delivery of therapeutic agents, and vaccine development.

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Polysaccharide-Rich Extract of Phragmites rhizome Attenuates Water Immersion Stress and Forced Swimming Fatigue in Rodent Animal Model

Cited by 10 publications

References 52 publications

Ameliorative Effects of Humulus japonicus Extract and Polysaccharide-Rich Extract of Phragmites rhizoma in Rats with Gastrointestinal Dysfunctions Induced by Water Avoidance Stress

Ameliorative Effects of Humulus japonicus Extract and Polysaccharide-Rich Extract of Phragmites rhizoma in Rats with Gastrointestinal Dysfunctions Induced by Water Avoidance Stress

Dietary Polysaccharides Exert Anti-Fatigue Functions via the Gut-Muscle Axis: Advances and Prospectives

Polysaccharide Chemistry in Drug Delivery, Endocrinology, and Vaccines

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