Polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota

Qiao, Yichun; Liu, Changzhong; Guo, Yongpeng; Zhang, Wei; Guo, Weibing; Kyselov, Oleksandr; Wang, Zhixiang

doi:10.1016/j.psj.2022.101905

Cited by 49 publications

(49 citation statements)

References 42 publications

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“…Bacteroides is one of the predominant genera of anaerobic bacteria in the chicken cecum [ 50 ]. Previous studies have shown that Bacteroides was positively related to serum inflammatory cytokines TNF-a, IL-1b and IL-6 and dietary supplementation with APS and GPS could inhibit the proliferation of Bacteroides [ 20 ]. Liu et al [ 46 ] showed that the abundance of Bacteroides in broilers fed with γ-irradiated Astragalus polysaccharides was lower than those in the cyclophosphamide-treated groups.…”

Section: Discussionmentioning

confidence: 99%

“…Adding 1500 mg/kg Glycyrrhiza polysaccharide could increase the activity of serum T-SOD in broilers and inhibit the decrease of T-SOD activity and the increase of MDA content induced by lipopolysaccharide [ 19 ]. GPS has the potential to improve broiler growth performance by improving intestinal health and modulating gut microbiota [ 20 ]. The compatibility of Astragalus and Glycyrrhiza can promote the synergistic effect and improve efficacy [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Compound Polysaccharides Derived from Astragalus and Glycyrrhiza on Growth Performance, Meat Quality and Antioxidant Function of Broilers Based on Serum Metabolomics and Cecal Microbiota

et al. 2022

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This study aimed to evaluate the effects of dietary supplementation of compound polysaccharides derived from Astragalus and Glycyrrhiza on growth performance, meat quality, antioxidant function, cecal microbiota and serum metabolomics of broilers. A total of 480 one-day-old male Arbor Acres (AA) broilers were randomly divided into four treatments with six replicates comprising 20 broilers each. Treatments: CON group was the basal diet; ANT group was supplemented with Terramycin calcium; LAG group was supplemented with 150 mg/kg Astragalus polysaccharides and 75 mg/kg Glycyrrhiza polysaccharides; HAG group was supplemented with 300 mg/kg Astragalus polysaccharides and 150 mg/kg Glycyrrhiza polysaccharides. The results showed that LAG and HAG supplementation increased growth performance, antioxidant function and meat quality compared with the CON group and ANT group and, especially, the effect of LAG treatment was better than HAG. Analysis of cecal microbiota showed that LAG and HAG supplementation altered cecal microbial diversity and composition in broilers. Serum metabolomics analysis showed that a total of 193 differential metabolites were identified in CON and LAG groups, which were mainly enriched in linoleic acid metabolism and glutathione metabolism pathways. Moreover, there was a close correlation between serum metabolites, cecal microbiota and phenotypic indicators. Conclusion: Dietary supplementation of 150 mg/kg Astragalus polysaccharides and 75 mg/kg Glycyrrhiza polysaccharides could improve the growth performance, antioxidant function and meat quality of broilers by changing the serum metabolites and cecal microbiota composition.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Compound Polysaccharides Derived from Astragalus and Glycyrrhiza on Growth Performance, Meat Quality and Antioxidant Function of Broilers Based on Serum Metabolomics and Cecal Microbiota

et al. 2022

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“…The study found that dietary supplementation with γ-irradiated Astragalus polysaccharides decreased plasma D-LA concentration in broilers [ 30 ]. Moreover, dietary supplementation with 300 mg/kg Astragalus polysaccharides or 150 mg/kg Glycyrrhiza polysaccharides reduced serum DAO activity [ 17 ]. However, the dietary inclusion of 500 mg/kg alfalfa polysaccharides increased DAO content in the duodenum and jejunum of broilers [ 34 ].…”

Section: Effects Of Plant-derived Polysaccharides On Intestinal Barri...mentioning

confidence: 99%

“…Studies have found that plant-derived polysaccharides could maintain the integrity of the intestinal barrier, reduce the level of intestinal inflammation, repair damaged intestinal tissue, restore normal intestinal structure, and assist the digestion and absorption of nutrients in poultry [ 8 , 16 , 17 ]. The small intestine is considered an important digestive and absorption organ in poultry, and is the largest immune organ.…”

Section: Introductionmentioning

confidence: 99%

Progress of Studies on Plant-Derived Polysaccharides Affecting Intestinal Barrier Function in Poultry

Guo

Xing

et al. 2022

Animals

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As natural bioactive components, plant-derived polysaccharides have many biological functions, such as anti-inflammatory, antioxidant, anticoccidial, and immunity regulation, and have been widely used in poultry production. In this review paper, firstly, the sources and structures of plant-derived polysaccharides are reviewed; secondly, the effects of plant-derived polysaccharides on the intestinal microbiome, permeability, morphology and immune function of poultry are summarized; thirdly, the potential molecular regulation mechanism of plant-derived polysaccharides on the intestinal barrier function of poultry was preliminarily analyzed. The review paper will bring a basis for the scientific utilization of plant-derived polysaccharides in the poultry industry.

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“…Recently, many studies have suggested that Glycyrrhiza polysaccharides perform a wide range of biological functions. Research reported that dietary supplementation with Glycyrrhiza polysaccharide improves the growth, development, and serum antioxidant levels of chickens raised for meat (30). In addition, Glycyrrhiza polysaccharides also has the ability to improve growth, and the quantities of white blood cell, neutrophils, red blood cells, and platelets, as well as elevate alkaline phosphatase, total protein, globulin, glucose, triglycerides, immunoglobulin A, immunoglobulin G, total antioxidant capacity levels, and immune responses in mice, quails, and weaned piglets (31)(32)(33).…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory and antioxidant effects of Glycyrrhiza uralensis polysaccharide in Lohmann Brown chickens

et al. 2022

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Glycyrrhiza polysaccharide extract 1 (GPS-1) is a bioactive component isolated from Glycyrrhiza uralensis, also known as Chinese licorice. It appears to be pharmacologically active as an antibacterial, antiviral, and anti-tumor agent. GPS-1 has also been shown to buffer liver health and regulate the immune system. Moreover, GPS-1 is low cost and easy to extract. More study was needed to elucidate the biochemical pathways underlying the immunomodulatory and antioxidant benefits observed in Glycyrrhiza polysaccharide extract 1 (GPS-1). in vitro experiments on chicken lymphocytes and dendritic cells (DCs) show that GPS-1 significantly promotes the proliferation of immune cells and is linked to lymphocytes' secretion of IL-12, IFN-γ, and TNF-α by. DC secretion of NO, IL-2, IL-1β, IFN-γ, TNF-α, and IL-12p70 was also increased significantly. Additionally, GPS-1 also displayed a significant antioxidant effect in vitro, able to scavenge DPPH, hydrogen peroxide, ABTS, and other free radicals like superoxide anions. Separately, GPS-1 was tested in vivo in combination with the Newcastle disease virus (NDV) – attenuated vaccine. 120 Lohmann Brown chickens were vaccinated, while another 30 became the unvaccinated blank control (BC) group. For three consecutive days 1 mL of GPS-1 was administered at doses of 19.53 μg/mL, 9.77 μg/mL, or 4.88 μg/mL to the ND-vaccinated birds, except for the vaccine control (VC), where n = 30 per group. In vivo results show that GPS-1 combined with Newcastle disease (ND) vaccine had the best efficacy at significantly increasing chickens' body weight and ND serum antibody titer, enhancing their secretion of IL-2 and IFN- γ, and promoting the development of immune organs. The results also indicate that GPS-1 was able increase the proliferation of in vitro immune cells and elevate their cytokine secretion, which enhances the body's immune response. GPS-1 also clearly has the potential to be used as an immune adjuvant alongside ND vaccination.

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Polysaccharides derived from Astragalus membranaceus and Glycyrrhiza uralensis improve growth performance of broilers by enhancing intestinal health and modulating gut microbiota

Cited by 49 publications

References 42 publications

Effects of Compound Polysaccharides Derived from Astragalus and Glycyrrhiza on Growth Performance, Meat Quality and Antioxidant Function of Broilers Based on Serum Metabolomics and Cecal Microbiota

Effects of Compound Polysaccharides Derived from Astragalus and Glycyrrhiza on Growth Performance, Meat Quality and Antioxidant Function of Broilers Based on Serum Metabolomics and Cecal Microbiota

Progress of Studies on Plant-Derived Polysaccharides Affecting Intestinal Barrier Function in Poultry

Immunomodulatory and antioxidant effects of Glycyrrhiza uralensis polysaccharide in Lohmann Brown chickens

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