Polysaccharides from Armillariella tabescens mycelia mitigate DSS-induced ulcerative colitis via modulating intestinal microbiota in mice

Yang, Rui; Wang, Yuan‐Yuan; Mehmood, Shomaila; Zhao, Min; Yang, Xingxing; Liu, Ying; Wang, Wei; Chen, Jinwu; Jia, Qiang

doi:10.1016/j.ijbiomac.2023.125538

Cited by 12 publications

(9 citation statements)

References 44 publications

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“…DOPL likely restored the supply of SCFAs by significantly increasing the relative abundance of this bacterium compared to that of the MC group. Studies on Prevotellaceae_UCG_001 are currently somewhat controversial, but it is generally recognized as the bacterium that produces SCFAs . There was no significant difference in relative abundance between the experimental groups, suggesting that it has no specific role in the development of colitis, but the results in the DOPL group were close to those in the NC group.…”

Section: Discussionmentioning

confidence: 84%

“…The results of the DOPL treatment were similar to the former. Previous studies have clarified that Lachnospiraceae_NK4A136_group can increase SCFAs, IL-10, SOD, and Occludin levels to relieve inflammation in UC mice Oscillospiraceae is a key bacterium in the acetate and butyrate production pathway, and DOPL treatment restored the decrease in the relative abundance of unclassified_Oscillospiraceae caused by DSS, which may be closely related to the final increase in the level of SCFAs in DOP groups.…”

Section: Discussionmentioning

confidence: 90%

“…Previous studies have clarified that Lachnospir-aceae_NK4A136_group can increase SCFAs, IL-10, SOD, and Occludin levels to relieve inflammation in UC mice. 50 Oscillospiraceae is a key bacterium in the acetate and butyrate production pathway, 58 50 There was no significant difference in relative abundance between the experimental groups, suggesting that it has no specific role in the development of colitis, but the results in the DOPL group were close to those in the NC group. Notably, the abundance of uncultured_Bacteroidales_bacterium in the DOPL group was significantly higher than that in the NC group (p < 0.01).…”

Section: Discussionmentioning

confidence: 97%

“…All in all, the most important role of SCFAs in the inflammatory response of the body is to promote the differentiation of intestinal epithelial cells and mucin secretion and regulate inflammation by inhibiting the production of cytokines in immune cells through the histone deacetylases pathway. 50,51 The abundance and function of Akkermansia differ in acute and chronic colitis models. 52,53 But in general, Akkermansia mainly degrades mucin and produces propionic acid in the intestinal mucus layer, which stimulates goblet cell differentiation to maintain the integrity of mucosal barriers.…”

Section: Discussionmentioning

confidence: 99%

“…At present, accumulating studies have confirmed that certain bacteria as SCFAs’ producers (e.g., Akkermansia, Dubosiella, Lachnospiraceae_NK4A136_group , unclassified_Oscillospiraceae , Colidextribacter , Prevotellaceae_UCG_001 , and Faecalibaculum_rodentium in this study) can fight colitis through different mechanisms. All in all, the most important role of SCFAs in the inflammatory response of the body is to promote the differentiation of intestinal epithelial cells and mucin secretion and regulate inflammation by inhibiting the production of cytokines in immune cells through the histone deacetylases pathway. , The abundance and function of Akkermansia differ in acute and chronic colitis models. , But in general, Akkermansia mainly degrades mucin and produces propionic acid in the intestinal mucus layer, which stimulates goblet cell differentiation to maintain the integrity of mucosal barriers . After treatment with DOPL, the abundance of Akkermansia and the level of propionate were restored.…”

Section: Discussionmentioning

confidence: 99%

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Phenolics from Dendrobium officinale Leaf Ameliorate Dextran Sulfate Sodium-Induced Chronic Colitis by Regulating Gut Microbiota and Intestinal Barrier

Wang,

Cai,

Yang

et al. 2023

J. Agric. Food Chem.

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The increasing incidence of colitis and the side effects of its therapeutic drugs have led to the search for compounds of natural origin, including phenolics, as new treatments for colitis. In this study, the potential mechanism of Dendrobium officinale leaf phenolics (DOP) on the relief of dextran sulfate sodium (DSS)-induced colitis was explored. The results showed that DOP treatment for 36 days reduced the symptoms of colitis caused by DSS, including reduction of the disease activity index and alleviation of colonic tissue damage. In addition, DOP downregulated the expression of key proteins of the TLR4/NF-κB signaling pathway and reduced the production of inflammatory cytokines. Furthermore, DOP could enhance the expression of tight junction proteins including ZO-1, Occludin, and Claudin-1 to restore intestinal mucosal barrier function. DOP also effectively regulates disordered intestinal flora and enhances the production of short-chain fatty acids, which is also beneficial in modulating gut internal environmental homeostasis, inhibiting inflammation, and restoring the intestinal barrier. These findings indicated that DOP can ameliorate DSS-induced chronic colitis by regulating gut microbiota, intestinal barrier, and inflammation, and it is a promising ingredient from D. officinale.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Phenolics from Dendrobium officinale Leaf Ameliorate Dextran Sulfate Sodium-Induced Chronic Colitis by Regulating Gut Microbiota and Intestinal Barrier

Wang,

Cai,

Yang

et al. 2023

J. Agric. Food Chem.

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Holothuria leucospilota polysaccharides (HLP) ameliorate colitis rats via regulation of the metabolic profiling and TLR4/NLRP3 signaling pathways

Zhang,

Shi,

et al. 2024

Food Frontiers

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Recently, the development of natural polysaccharides for ameliorating immunity and gut metabolism has attracted extensive attention. This study used Holothuria leucospilota polysaccharides (HLP) to explore the improvement mechanism in ulcerative colitis rats on perspectives of immunity and metabolism. The results showed that HLP increased goblet cells’ number and the content of tight junction proteins (zona occludens 1 and occludin) and improved intestinal barrier permeability. The levels of immune cytokines (IL‐4, IL‐6, IL‐10, IL‐18, TNF‐α, and IL‐1β) and the activity of oxidative stress‐related enzymes (superoxide dismutase, catalase, malondialdehyde, and glutathione peroxidase) were regulated. HLP regulated the related genes and proteins expression of immune cytokines, MAPK, and NLRP3 inflammasome. Furthermore, HLP treatment increased the concentration of short‐chain fatty acids (SCFAs) and regulated serum metabolic disorders by regulating amino acid metabolism, SCFA metabolism, and energy metabolism. These results provide a new perspective for developing HLP as a promising functional food for preventing and mitigating colitis.

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Phenolics‐Rich Extract from Agarwood Leaf‐Tea Alleviate Dextran Sulfate Sodium (DSS)‐Induced Ulcerative Colitis Via Modulating Intestinal Barrier Function, Liver Inflammation, and Gut Microbiota

Fan,

Wei,

Wei

et al. 2024

Molecular Nutrition Food Res

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ScopeAt present, the incidence rate of ulcerative colitis (UC) continues to increase, causing a global burden. In addition, therapeutic drugs have great side effects. According to modern pharmacology, agarwood leaves have anti‐inflammatory, antibacterial, hypoglycemic, and lipid‐lowering effects. Therefore, this experiment on DSS induced colitis treatment of polyphenolic substances in agarwood leaves is feasible and in line with the current hot topic of using natural substances instead of drugs for treatment.Methods and resultsALP supplementation promotes the expression of tight junction proteins occludin and Zonula occludens protein 1 (ZO‐1) on colonic tissues, repairs the intestinal barrier, and relieves further colonic tissue damage. Besides, ALP effectively inhibits the activation of nuclear factor kappa‐B (NF‐кB) signaling pathway and reduces the release of proinflammatory cytokines. Moreover, ALP reverses the alteration of gut microbiota in the colitic mice by increasing the abundances of Parabacteroides, Chlamydia, and Lachnospiraceae, and decreasing the abundances of Bacteroides and Phocaeicola. Furthermore, the correlation analysis suggested that ALP can attenuate DSS‐induced UC, which is probably related to the alterations in the gut microbiota.ConclusionALP can ameliorate DSS‐induced UC by modulating gut microbiota, intestinal barrier function, and inflammatory responses.

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Polysaccharides from Armillariella tabescens mycelia mitigate DSS-induced ulcerative colitis via modulating intestinal microbiota in mice

Cited by 12 publications

References 44 publications

Phenolics from Dendrobium officinale Leaf Ameliorate Dextran Sulfate Sodium-Induced Chronic Colitis by Regulating Gut Microbiota and Intestinal Barrier

Phenolics from Dendrobium officinale Leaf Ameliorate Dextran Sulfate Sodium-Induced Chronic Colitis by Regulating Gut Microbiota and Intestinal Barrier

Holothuria leucospilota polysaccharides (HLP) ameliorate colitis rats via regulation of the metabolic profiling and TLR4/NLRP3 signaling pathways

Phenolics‐Rich Extract from Agarwood Leaf‐Tea Alleviate Dextran Sulfate Sodium (DSS)‐Induced Ulcerative Colitis Via Modulating Intestinal Barrier Function, Liver Inflammation, and Gut Microbiota

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