Polysaccharides from Caesalpinia ferrea seeds – Chemical characterization and anti-diabetic effects in Wistar rats

Cunha, Arcelina Pacheco; Ribeiro, Ana Carolina Barbosa; Ricardo, Nadja M. P. S.; Oliveira, Ariclécio Cunha de; d'Avila, Liohanna Silva Pires; Leal‐Cardoso, J. H.; Rodrigues, Delane C.; Azeredo, Henriette Monteiro Cordeiro de; Silva, Lorena; Brito, Edy Sousa de; Fílho, J. Mendes; Rocha, Talita Magalhães; Leal, Luzia Kalyne Almeida Moreira; Ricardo, Nágila Maria Pontes Silva

doi:10.1016/j.foodhyd.2016.10.039

Cited by 32 publications

(20 citation statements)

References 53 publications

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“…Diabetes mellitus is characterized by hyperglycemia owing to either a decrease in insulin production, insulin resistance, or both 1 . It can be classified into type 1, which results from autoimmune destruction of the pancreatic beta cells, and type 2, which occurs owing to insulin resistance or deficiency 2 .…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of balanitoside in streptozotocin-induced diabetic rats

Makena

Hamman

Buraimoh

et al. 2018

Journal of Taibah University Medical Sciences

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Objectives The objective of this study was to evaluate the therapeutic effects of balanitoside in diabetic rats. Methods Twenty-five rats were divided into five groups. Rats in groups 2 to 5 were treated with streptozotocin to induce hyperglycemia. In addition, rats in groups 1 and 2 received 1 mL of distilled water, whereas those in groups 3, 4, and 5 received 10 and 20 mg/kg balanitoside and 6 U/kg insulin, respectively, for 14 days. All rats were sacrificed on day 15, blood samples were collected, and serum levels of alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were measured. The liver was processed for examination under a light microscope. Results The results showed a significant decrease in liver protein concentrations in diabetic control rats, compared to those in the normal control rats and rats treated with 10 mg/kg balanitoside ( p < 0.05). There was no significant difference in ALP levels among all groups. However, a significant increase in ALT and AST levels was observed in the diabetic control rats, compared to those in the normal control rats ( p < 0.05). Photomicrographs of the liver of the diabetic control rats showed fat and glycogen droplets, vacuolated nuclei, and loss of cellular boundaries, whereas those of the rats treated with balanitoside or insulin showed a small amount of microvesicular fat droplets and slight infiltration of lymphocytes. Conclusion The findings of this study suggest the therapeutic effects of balanitoside in the liver of diabetic rats.

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Section: Introductionmentioning

confidence: 99%

Therapeutic effects of balanitoside in streptozotocin-induced diabetic rats

Makena

Hamman

Buraimoh

et al. 2018

Journal of Taibah University Medical Sciences

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“…The species of the subfamily Caesalpiniaceae present hydrophilic polysaccharides such as galactomannans with a the mannose/galactose ratio ranging from 2.5:1 to 4.3:1 [ 63 ]. In C. ferrea , the presence of these polysaccharides was detected by different authors, and these biomolecules are chemotaxonomic markers used to the analysis and identification of these species [ 64 , 65 ]. Other chemical compounds useful as chemotaxonomic markers of Caesalpiniaceae are flavonoids, terpenoids, and isoflavonoids [ 12 , 14 , 48 , 66 ].…”

Section: Resultsmentioning

confidence: 99%

Caesalpinia ferrea C. Mart. (Fabaceae) Phytochemistry, Ethnobotany, and Bioactivities: A Review

et al. 2020

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Caesalpinia ferrea C. Mart., popularly known as “Jucá” or “Pau-ferro”, belongs to the Fabaceae family, and is classified as a native and endemic species in Brazil. Numerous studies that portray its ethnobotany, chemical composition, and biological activities exist in the literature. The present study aimed to systematically review publications addressing the botanical aspects, uses in popular medicine, phytochemical composition, and bioactivities of C. ferrea. The searches focused on publications from 2015 to March 2020 using the Scopus, Periódicos Capes, PubMed, Google Scholar, and ScienceDirect databases. The leaves, fruits, seeds, and bark from C. ferrea are used in popular medicine to treat disorders affecting several systems, including the circulatory, immune, cardiovascular, digestive, respiratory, genitourinary, musculoskeletal, and conjunctive systems. The most commonly found chemical classes in phytochemical studies are flavonoids, polyphenols, terpenoids, tannins, saponins, steroids, and other phenolic compounds. The biological properties of the extracts and isolated compounds of C. ferrea most cited in the literature were antibacterial, antifungal, antioxidant, antiproliferative, anti-inflammatory, and healing potential. However, further studies are still needed to clarify a link between its traditional uses, the active compounds, and the reported pharmacological activities, as well as detailed research to determine the toxicological profile of C. ferrea.

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“…A banda 1163 é de grupo C-O do anel piranosídico das amostras. As bandas em 995 e 878 cm -1 são relacionadas a ligações anoméricas dos grupos D-manopiranoses e Dgalactopiranoses, respectivamente, adequadas ao ciclo piranosídico também identificadas por Cunha, et al (2017).…”

Section: Análisesunclassified

Potencial antioxidante e estabilidade do bioaditivo de jucá (Libidibia ferrea)

Grisi

Cordeiro

Nascimento

et al. 2020

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The juca is a common plant in northeastern Brazil, has its known antioxidant capacity and proven therapeutic power. However, there is little information about its use as an antioxidant bioadditive in soybean oil. Thus, the antioxidant efficacy of the aqueous and hydroalcoholic extracts of the juca was investigated, through analysis in vitro (by total phenolic compounds, antioxidant activity by free radical scavenger method - DPPH and by iron reducer method – FRAP), and in vivo (by oil with juca extracts, monitoring its oxidation during a 90-days). Hydroalcoholic extracts from juca showed greater oxidative stability than aqueous extracts. The hydroalcoholic extracts of the juca showed high levels of phenolic compounds (166.59 mgEAG / g of fruit and 179.55 mgEAG / g of stem bark), and high antioxidant activities by the methods of DPPH and FRAP, at the end of 90 days. The in vivo investigations indicated that the formulation of hydroalcoholic extract with 0.85% of the fruit and 0.85% of the stem bark showed a greater protective effect against the increase of the peroxide index in the soybean oil, showing that the simultaneous use of the additives have synergistic antioxidant effect. Therefore, juca hydroalcoholic extracts can be used as an antioxidant bioadditive in soybean oil.

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Polysaccharides from Caesalpinia ferrea seeds – Chemical characterization and anti-diabetic effects in Wistar rats

Cited by 32 publications

References 53 publications

Therapeutic effects of balanitoside in streptozotocin-induced diabetic rats

Therapeutic effects of balanitoside in streptozotocin-induced diabetic rats

Caesalpinia ferrea C. Mart. (Fabaceae) Phytochemistry, Ethnobotany, and Bioactivities: A Review

Potencial antioxidante e estabilidade do bioaditivo de jucá (Libidibia ferrea)

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