Polysaccharides from<i>Armillariella tabescens</i>mycelia ameliorate insulin resistance in type 2 diabetic mice

Yang, Rui; Li, Yangdan; Cai, Jingjing; Ji, Junqiu; Wang, Ya; Zhang, Wenna; Pan, Wen-Juan; Chen, Yan

doi:10.1039/d0fo00728e

Cited by 19 publications

(5 citation statements)

References 44 publications

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“…FBG and GSP are commonly used to assess blood glucose levels, while triglycerides and T-CHO reflect the levels of blood lipids in type 2 diabetes. 24 Growing studies suggest that elevated AGEs levels, caused by a glucose-induced metabolic disorder in type 2 diabetes, are a crucial player in the progression of kidney disease. 25 In the current work, our experimental data showed that in the DN group, FBG, GSP, triglycerides, T-CHO, and AGEs were higher than those in the normal rats, indicating that the model of type 2 diabetic rats was successfully established.…”

Section: Discussionmentioning

confidence: 99%

Epigallocatechin-3-gallate ameliorates renal endoplasmic reticulum stress-mediated inflammation in type 2 diabetic rats

Yang

Chen

Jia

et al. 2022

Exp Biol Med (Maywood)

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Epigallocatechin-3-gallate (EGCG), an essential polyphenolic constituent found in tea leaves, possesses various potent biological activities. This research was undertaken to investigate the impact of EGCG against endoplasmic reticulum (ER) stress-mediated inflammation and to clarify the underlying molecular mechanism in type 2 diabetic kidneys. The male rats were randomized into four groups: normal, diabetic, low-dose EGCG, and high-dose EGCG. In type 2 diabetic rats, hyperglycemia and hyperlipidemia noticeably caused renal structural damage and dysfunction and aggravated ER stress. Meanwhile, sustained ER stress activated the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome and then upregulated the contents of inflammatory cytokines in the diabetic kidney. Following supplementation with 40 mg/kg and 80 mg/kg EGCG, hyperglycemia, hyperlipidemia, and renal histopathological alterations and dysfunction were noticeably ameliorated; renal ER stress, NLRP3 inflammasome, and inflammatory response were markedly repressed in the EGCG treatment groups. In summary, the current study highlighted the renoprotective effects of EGCG in type 2 diabetes and its mechanisms are mainly associated with the repression of ER stress-mediated NLRP3 inflammasome overactivation.

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Section: Discussionmentioning

confidence: 99%

Epigallocatechin-3-gallate ameliorates renal endoplasmic reticulum stress-mediated inflammation in type 2 diabetic rats

Yang

Chen

Jia

et al. 2022

Exp Biol Med (Maywood)

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“…Armillariella tabescens (AT), that belongs to the family of Tricholomataceae , is a well-known traditional medicinal mushroom, characterized by 86.52% of polysaccharides (mannose, arabinose, and fucose at a molar ratio of 1.6:1.0:2.7.). AT possesses potent antioxidant and anti-inflammatory properties by possibly involving the repression of the TXNIP/NLRP3 inflammasome pathway in the liver of T2D mice [ 127 ]. Among the plant-derived polysaccharides, low methoxyl pectin (LMP) showed an important role in the autoimmune diabetes through suppression of NLRP3 and associated proteins expression in cecum (NLRP3, caspase-1-p20, cleaved IL-1𝛽, and cleaved IL-18) [ 128 ].…”

Section: Food Components As Nlpr3 Modulatorsmentioning

confidence: 99%

Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

et al. 2022

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Inflammasomes are key intracellular multimeric proteins able to initiate the cellular inflammatory signaling pathway. NLRP3 inflammasome represents one of the main protein complexes involved in the development of inflammatory events, and its activity has been largely demonstrated to be connected with inflammatory or autoinflammatory disorders, including diabetes, gouty arthritis, liver fibrosis, Alzheimer’s disease, respiratory syndromes, atherosclerosis, and cancer initiation. In recent years, it has been demonstrated how dietary intake and nutritional status represent important environmental elements that can modulate metabolic inflammation, since food matrices are an important source of several bioactive compounds. In this review, an updated status of knowledge regarding food bioactive compounds as NLRP3 inflammasome modulators is discussed. Several chemical classes, namely polyphenols, organosulfurs, terpenes, fatty acids, proteins, amino acids, saponins, sterols, polysaccharides, carotenoids, vitamins, and probiotics, have been shown to possess NLRP3 inflammasome-modulating activity through in vitro and in vivo assays, mainly demonstrating an anti-NLRP3 inflammasome activity. Plant foods are particularly rich in important bioactive compounds, each of them can have different effects on the pathway of inflammatory response, confirming the importance of the nutritional pattern (food model) as a whole rather than any single nutrient or functional compound.

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“…The liver cells in the PSP‐L group were more severely damaged with more vacuoles, but the outline was clear than that of the model group. The above results indicate that PSP has a particular repair effect on the damaged liver tissues of T2DM mice and can avert the massive lipid deposition in the liver in diabetic mice (Yang et al., 2020).…”

Section: Resultsmentioning

confidence: 92%

Structural characterization and hypoglycemic effect of polysaccharides of Polygonatum sibiricum

Wang,

Yang,

Shen

et al. 2024

Journal of Food Science

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Polygonatum sibiricum polysaccharide (PSP) was extracted and purified from raw material obtained from P. sibiricum. The structural features of PSP were investigated by Congo red, circular dichroism spectrum, high‐performance gel permeation chromatography, scanning electron microscope, atomic force microscope, ultraviolet spectroscopy, and Fourier transform infrared spectroscopy analysis. In vitro simulations were conducted to investigate the kinetics of PSP enzyme inhibition. Moreover, a type II diabetes mouse model (T2DM) with streptozotocin‐induced insulin resistance was established, and the indexes of lipid quadruple, insulin resistance index, oral glucose tolerance (OGTT), organ index, and pancreatic morphology of model mice were measured. The results showed that PSP mainly consists of monosaccharides, such as mannose, glucose, galactose, xylose, and arabinose. It also has a β‐glycosidic bond of a pyranose ring and an irregular reticulated aggregated structure with a triple helix. In vitro enzyme inhibition assays revealed that PSP acts as a reversible competitive inhibitor of α‐glucosidase and α‐amylase. Furthermore, PSP was found to reduce insulin resistance index, increase OGTT and serum insulin levels, decrease free fatty acid content to improve lipid metabolism, and lower glycated serum protein content to enhance glucose metabolism in T2DM mice, thereby leading to a reduction in blood glucose concentration. Additionally, PSP exhibited reparative effects on the damaged liver tissue cells and pancreatic tissue in T2DM mice. The experiment results provide a preliminary basis for the therapeutic mechanism of PSP about type II diabetes and a theoretical reference for application in food and pharmaceutical development.

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Polysaccharides fromArmillariella tabescensmycelia ameliorate insulin resistance in type 2 diabetic mice

Abstract: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia mainly due to insulin resistance. The objective of this study was to investigate the effects of polysaccharides...

Cited by 19 publications

References 44 publications

Epigallocatechin-3-gallate ameliorates renal endoplasmic reticulum stress-mediated inflammation in type 2 diabetic rats

Epigallocatechin-3-gallate ameliorates renal endoplasmic reticulum stress-mediated inflammation in type 2 diabetic rats

Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

Structural characterization and hypoglycemic effect of polysaccharides of Polygonatum sibiricum

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