Polysaccharides from Portulaca oleracea L. regulated insulin secretion in INS-1 cells through voltage-gated Na  channel

Hu, Qingjuan; Niu, Qingchuan; Song, Hao; Wei, Shanshan; Wang, Songhua; Yao, Lihua; Li, Yuping

doi:10.1016/j.biopha.2018.10.113

Cited by 25 publications

(15 citation statements)

References 31 publications

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“…The ratio of n-6 to n-3 fatty acids in purslane is low (<2) (Nemzer et al, 2020); and this is important since the imbalance between n-6 to n-3 polyunsaturated fatty acids, as found in western diet, may increase the risk of NAFLD (Jeyapal et al, 2018). Moreover, various bioactive compounds have been isolated from purslane including vitamins and minerals, flavonoids, alkaloids, fatty acids, amino acids (Alam et al, 2014;Nemzer et al, 2020), and polysaccharides (Hu et al, 2019). Purslane polysaccharides have been introduced as bioactive compounds, which may modulate insulin secretion/production in insulin-secreting β-cell line cells (INS-1 cells) (Hu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Effect of Portulaca Oleracea (purslane) extract on liver enzymes, lipid profile, and glycemic status in nonalcoholic fatty liver disease: A randomized, double‐blind clinical trial

Damavandi

Shidfar

Najafi

et al. 2021

Phytotherapy Research

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Section: Introductionmentioning

confidence: 99%

Effect of Portulaca Oleracea (purslane) extract on liver enzymes, lipid profile, and glycemic status in nonalcoholic fatty liver disease: A randomized, double‐blind clinical trial

Damavandi

Shidfar

Najafi

et al. 2021

Phytotherapy Research

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“…Especially important, given the high NCD (particularly diabetes) rates in the Pacific and northern Australia, are the anti-diabetes and anti-cardiovascular disease effects of most of the plants featured in the factsheets, demonstrated in scientific studies. Studies with evidence for this include the following: drumstick [ 36 , 37 , 38 , 50 , 60 ], amaranth [ 61 , 62 , 63 ], bele [ 64 , 65 , 66 ], chilli [ 67 , 68 , 69 ], purslane [ 70 , 71 , 72 ], kangkong [ 73 , 74 , 75 ], ofenga [ 76 , 77 , 78 ], hedge panax [ 79 , 80 ], chaya [ 39 , 40 ], pumpkin [ 81 , 82 ], and choko [ 83 , 84 ]. Their inclusion in the diet in sufficient quantity is likely to reduce the risk of diabetes and cardiovascular disease, not only by reducing glycemic load when they are included with high-carbohydrate meals, but also because of specific anti-diabetes effects.…”

Section: Resultsmentioning

confidence: 99%

Macro- and Micronutrients from Traditional Food Plants Could Improve Nutrition and Reduce Non-Communicable Diseases of Islanders on Atolls in the South Pacific

Lyons

Dean

Tongaiaba³

et al. 2020

Plants

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Pacific Islanders have paid dearly for abandoning traditional diets, with diabetes and other non-communicable diseases (NCD) widespread. Starchy root crops like sweet potato, taro, and cassava are difficult to grow on the potassium-deficient soils of atolls, and high energy, low nutrient imported foods and drinks are popular. Nutritious, leafy food plants adapted to alkaline, salty, coral soils could form part of a food system strategy to reduce NCD rates. This project targeted four atolls south of Tarawa, Kiribati, and was later extended to Tuvalu. Mineral levels in diverse, local leafy food plants were compared to reveal genotype–environment interactions. Food plants varied in ability to accumulate minerals in leaves and in tolerance of mineral-deficient soils. Awareness activities which included agriculture, health, and education officers targeted atoll communities. Agriculture staff grew planting material in nurseries and provided it to farmers. Rejuvenation of abandoned giant swamp taro pits to form diversified nutritious food gardens was encouraged. Factsheets promoted the most suitable species from 24 analyzed, with multiple samples of each. These included Cnidoscolus aconitifolius (chaya), Pseuderanthemum whartonianum (ofenga), Polyscias scutellaria (hedge panax), and Portulaca oleracea (purslane). The promoted plants have been shown in other studies to have anti-NCD effects. Inclusion of the findings in school curricula and practical application in the form of demonstration school food gardens, as well as increased uptake by farmers, are needed. Further research is needed on bioavailability of minerals in plants containing phytates and tannins.

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“…The mechanism of biological yield of Portulaca Oleracea is not well known. Several mechanisms have been considered for the bene cial effects of Portulaca Oleracea to improve the metabolic indices of diabetes, including affecting membrane depolarization, calcium entry, improving insulin secretion by closing ATP / potassium adenosine triphosphate channels, and increasing glucagon peptide levels [52,53].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Bread Enriched With Portulaca Oleracea on Metabolic Control Indices in Patients With Type 2 Diabetes: a Parallel Randomized Clinical Trial

Delvarianzadeh¹,

Nafchi²,

Nouri³

et al. 2021

Preprint

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Background: Diabetes is the most common chronic disease worldwide. Some herbs are used to control diabetes. Portulaca Oleracea is a type of plant that has essential fatty acid-rich leaves. Objectives: This study aimed to evaluate the effect of bread enriched with Portulaca Oleracea on metabolic control indices in patients with type 2.Methods: This parallel randomized controlled clinical trial was conducted on 104 patients with type 2 diabetes. Participants received bulk bread containing 10% Portulaca powder for 4 weeks (intervention group), the control group used their normal daily bread. At baseline and end of the study a 12 hours fasting and 2 hours later blood sample were collected to quantify plasma glucose levels and lipid profiles. The effectiveness of the intervention method was compared with the difference between the mean before and after the intervention (change score) in the two groups using t-test.Results: The results showed that after the intervention, a significant difference was found between Fasting blood sugar, cholesterol and high-density lipoprotein variables in intervention groups, but could not affect serum low-density lipoprotein, triglyceride levels, blood sugar and Glycated hemoglobin(HbA1C) It should be noted that the difference between the means of the two groups before and after the intervention indicates that there is a significant difference between the other groups except HbA1C. Conclusions: consumption of bread enriched with portulaca oleracea did have a significant impact on metabolic indices of diabetes and improvement lipid profile. It is recommended to use bread enriched with portulaca oleracea powder, areas where the staple food is bread.Trial registration in the Iranian clinical trial system with the code IRCT2011030309006010N1.

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Polysaccharides from Portulaca oleracea L. regulated insulin secretion in INS-1 cells through voltage-gated Na channel

Cited by 25 publications

References 31 publications

Effect of Portulaca Oleracea (purslane) extract on liver enzymes, lipid profile, and glycemic status in nonalcoholic fatty liver disease: A randomized, double‐blind clinical trial

Effect of Portulaca Oleracea (purslane) extract on liver enzymes, lipid profile, and glycemic status in nonalcoholic fatty liver disease: A randomized, double‐blind clinical trial

Macro- and Micronutrients from Traditional Food Plants Could Improve Nutrition and Reduce Non-Communicable Diseases of Islanders on Atolls in the South Pacific

The Effect of Bread Enriched With Portulaca Oleracea on Metabolic Control Indices in Patients With Type 2 Diabetes: a Parallel Randomized Clinical Trial

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