Polysaccharides gums in drug delivery systems: A review

Putro, Jindrayani Nyoo; Soetaredjo, Felycia Edi; Lunardi, Valentino Bervia; Irawaty, Wenny; Yuliana, Maria; Santoso, Shella Permatasari; Puspitasari, Natania; Wenten, I. Gede; Ismadji, Suryadi

doi:10.1016/j.ijbiomac.2023.127020

Cited by 13 publications

(1 citation statement)

References 134 publications

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“…Other polysaccharides of marine (agar), microbial (xanthan gum), and plant (guar gum and locust bean gum) origins have also been studied for colonic administration purposes [90].…”

Section: Other Polysaccharidesmentioning

confidence: 99%

Aerogels as Carriers for Oral Administration of Drugs: An Approach towards Colonic Delivery

Illanes-Bordomás,

Landin,

García-González

2023

Pharmaceutics

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Polysaccharide aerogels have emerged as a highly promising technology in the field of oral drug delivery. These nanoporous, ultralight materials, derived from natural polysaccharides such as cellulose, starch, or chitin, have significant potential in colonic drug delivery due to their unique properties. The particular degradability of polysaccharide-based materials by the colonic microbiota makes them attractive to produce systems to load, protect, and release drugs in a controlled manner, with the capability to precisely target the colon. This would allow the local treatment of gastrointestinal pathologies such as colon cancer or inflammatory bowel diseases. Despite their great potential, these applications of polysaccharide aerogels have not been widely explored. This review aims to consolidate the available knowledge on the use of polysaccharides for oral drug delivery and their performance, the production methods for polysaccharide-based aerogels, the drug loading possibilities, and the capacity of these nanostructured systems to target colonic regions.

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“…Other polysaccharides of marine (agar), microbial (xanthan gum), and plant (guar gum and locust bean gum) origins have also been studied for colonic administration purposes [90].…”

Section: Other Polysaccharidesmentioning

confidence: 99%

Aerogels as Carriers for Oral Administration of Drugs: An Approach towards Colonic Delivery

Illanes-Bordomás,

Landin,

García-González

2023

Pharmaceutics

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Microencapsulation and characterization of pomegranate seed oil using gum Arabic and maltodextrin blends for functional food applications

Mangope,

Kaseke,

Fawole

2024

Food Science & Nutrition

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Pomegranate seed oil (PSO) is highly valued in the functional food industry due to its rich fatty acid content and associated health benefits. However, its high degree of unsaturation makes it susceptible to rapid degradation when exposed to oxygen and light. This study investigates the encapsulation of PSO at 15% w/w using different blends of gum Arabic (GA) and maltodextrin (MD) (1:0, 0:1, 1:1, 3:1, and 1:3) to determine optimal formulations for enhanced stability and functional quality. Characterization of the encapsulated PSO powders showed distinct particle morphologies, including flake‐like shapes and textures ranging from smooth to wrinkled and porous. The Fourier transform infrared (FT‐IR) spectra indicated shifts in functional groups from 2973.70 to 408.84 cm−1, revealing the presence of aliphatic, amine, aromatic, carboxylic acid, and hydroxyl groups. Although no single formulation achieved all desired outcomes, the GA:MD ratios of 1:0 and 1:1 were superior in enhancing color properties (yellowness and chroma), techno‐functional attributes (bulk density and solubility), and in preserving essential fatty acids, including stearic, cis‐oleic, α‐linolenic, arachidic, γ‐linolenic, linoleic, and punicic acids. Additionally, GA:MD (3:1) powders exhibited superior ferric‐reducing antioxidant power (FRAP) and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging activities (RSA). In conclusion, formulations using solely GA or GA:MD ratios of 1:1 and 3:1 effectively preserve bioactive content in PSO, enhancing its antioxidant capacity. These findings suggest promising applications for these encapsulated powders in developing functional foods that meet industry demands.

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Pharmaceutical applications of chitosan on medical implants: A viable alternative for construction of new biomaterials?

de Oliveira,

Sales Albuquerque,

Ribeiro Rodrigues

et al. 2024

Carbohydrate Polymer Technologies and Applications

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Polysaccharides gums in drug delivery systems: A review

Cited by 13 publications

References 134 publications

Aerogels as Carriers for Oral Administration of Drugs: An Approach towards Colonic Delivery

Aerogels as Carriers for Oral Administration of Drugs: An Approach towards Colonic Delivery

Microencapsulation and characterization of pomegranate seed oil using gum Arabic and maltodextrin blends for functional food applications

Pharmaceutical applications of chitosan on medical implants: A viable alternative for construction of new biomaterials?

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