Polysaccharides in Cancer Prevention: From Bench to Bedside

Banerjee, Sanjeev; Parasramka, Mansi; Paruthy, Shivani B.

doi:10.1007/978-3-319-16298-0_26

Cited by 10 publications

(5 citation statements)

References 126 publications

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“…Schizophyllan is obtained from Shizophyllum commune, a species of mushroom, which is an extensively studied polysaccharide with immune-modulating anti-tumor properties [180,181]. Schizophyllan with a molecular weight of~450 k Da, comprising of a β-(1→3)-d-glucopyranosyl main chain and β-(1→6)-d-glucopyranosyl side chains at every third monomer of the main chain [182]. Due to its reversible coiled-helical conformation, it generates a very firm triple-helical structure in water and in other aqueous solutions [183].…”

Section: Schizophyllanmentioning

confidence: 99%

“…Krestin, also known as polysaccharide k, is a protein-bound glycan derived from cultured mycelium Coriolus versicolor. Krestin (molecular weight; 1 × 105 Da) contains glucose as the main monosaccharide unit, having a β-(1-4) linkage main chain and a side chain as β-(1-3) and β-(1-6) that is covalently connected to protein constituent through β-(1-6) glucose side chain [ 162 , 182 ]. Noteworthy, a high degree of the structural complexity of polysaccharide molecule is suggestive of strong immunomodulatory and anti-tumor activity, as polysaccharides bound to proteins or peptides conferred more potent anti-tumor effects than the corresponding free glucans [ 151 , 188 ].…”

Section: Chemopreventive Activities Of Polysaccharidesmentioning

confidence: 99%

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Anti-neoplastic Potential of Flavonoids and Polysaccharide Phytochemicals in Glioblastoma

Atiq

Parhar

2020

Molecules

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Clinically, gliomas are classified into four grades, with grade IV glioblastoma multiforme being the most malignant and deadly, which accounts for 50% of all gliomas. Characteristically, glioblastoma involves the aggressive proliferation of cells and invasion of normal brain tissue, outcomes as poor patient prognosis. With the current standard therapy of glioblastoma; surgical resection and radiotherapy followed by adjuvant chemotherapy with temozolomide, it remains fatal, because of the development of drug resistance, tumor recurrence, and metastasis. Therefore, the need for the effective therapeutic option for glioblastoma remains elusive. Previous studies have demonstrated the chemopreventive role of naturally occurring pharmacological agents through preventing or reversing the initiation phase of carcinogenesis or arresting the cancer progression phase. In this review, we discuss the role of natural phytochemicals in the amelioration of glioblastoma, with the aim to improve therapeutic outcomes, and minimize the adverse side effects to improve patient’s prognosis and enhancing their quality of life.

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Section: Schizophyllanmentioning

confidence: 99%

Section: Chemopreventive Activities Of Polysaccharidesmentioning

confidence: 99%

Anti-neoplastic Potential of Flavonoids and Polysaccharide Phytochemicals in Glioblastoma

Atiq

Parhar

2020

Molecules

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“…(105) These effects induced anticancer effect indirectly though the activation of immune cells rather than via direct cytotoxic effects. (106,107) Watersoluble polysaccharide extracted from Sanguisorba of cinalis L., signi cantly inhibited the growth of mouse transplanted tumor, remarkably increased the spleen index and promoted splenocytes proliferation, M phagocytosis and secretion of serum cytokines IL-2, TNF-and IFN-in sarcoma 180-bearing mice in the absence of direct cytotoxic activity on tumor cells. These results indicated that the anti-tumor activity of SOP may be achieved through immune potentiation.…”

Section: Angiogenesis and Lymphangiogenesismentioning

confidence: 99%

Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Sun

Gao

et al. 2017

Chin. J. Integr. Med.

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Infiltration of the tumor microenvironment (TME) by immune and inflammatory cells is involved in promoting tumorigenesis, tumor progression, local invasion and metastasis.(1) Tumor-associated macrophages (TAMs), a prominent and abundant inflammatory component of solid and hematological malignancies, express a pro-and anti-tumor effect in all stages of carcinogenesis. Asian region. According to the theory of Chinese medicine (CM) and its practice, some Asian region. According to the theory of Chinese medicine (CM) and its practice, some prescriptions of CM regulate the body's internal environment possibly including the prescriptions of CM regulate the body's internal environment possibly including the remodeling the tumor microenvironment (TME). Here we brie y summarize the pivotal remodeling the tumor microenvironment (TME). Here we brie y summarize the pivotal effects of TAMs in shaping the TME and promoting tumorigenesis, invasion, metastasis effects of TAMs in shaping the TME and promoting tumorigenesis, invasion, metastasis and immunosuppression. Furthermore, we illustrate the effects and mechanisms of CMM targeting TAMs in antiand immunosuppression. Furthermore, we illustrate the effects and mechanisms of CMM targeting TAMs in antitumor therapy. Finally, we reveal the CMM's dual-regulatory and multi-targeting functions on regulating TAMs, tumor therapy. Finally, we reveal the CMM's dual-regulatory and multi-targeting functions on regulating TAMs, and hopefully, provide the theoretical basis for CMM clinical practice related to cancer therapy. and hopefully, provide the theoretical basis for CMM clinical practice related to cancer therapy.

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“…P Plant polysaccharides have shown promising anticancer properties in both laboratory settings (in vitro) and inside living organisms (in vivo) [20]. These plant-based polysaccharides, such as those found in dietary staples and medicinal herbs, demonstrate a multifaceted strategy to fight cancer [21]. They have proven to be capable of inducing apoptosis in cancer cells [22], disrupting critical signaling pathways for tumor growth [23], and preventing tumor-related angiogenesis [24].…”

Section: Introductionmentioning

confidence: 99%

Screening of Antioxidative and Antiproliferative Activities of Crude Polysaccharides Extracted from Six Different Plants

Adewale,

Wińska,

Krawczyk

et al. 2024

Applied Sciences

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Plant polysaccharides have gained interest in medical research for their ability to suppress various diseases, including cancer. However, information on some plant polysaccharides is yet to be uncovered. In this study, we screened crude polysaccharides extracted from six different plants for their antioxidative and antiproliferative activities. Crude polysaccharides were isolated from different parts of some plants using the established extraction protocol. The crude polysaccharides were evaluated for their chemical composition (protein, total sugar, and phenolics), free radical-scavenging activities, and antiproliferative activities against breast cancer MCF-7 cells as well as non-cancerous cells, i.e., human fibroblast MRC-5 cells and Cercopithecus aethiops kidney Vero cells, via an MTT assay and CM20 Incubation Monitoring System (Olympus) for MCF-7. The investigated crude polysaccharides showed significant variations in their chemical constituents and antioxidative properties. Only Moringa seed crude polysaccharide extracts showed significant antiproliferative activities at various concentrations, with an IC50 value of 0.061 mg/mL, which was about 2.6 folds higher on MRC-5 and Vero cell lines. The antiproliferative activities toward cancer cell lines and lack of significant toxicity in the case of normal cells indicate that this extract may be promising as a valuable source for novel cancer therapy.

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Polysaccharides in Cancer Prevention: From Bench to Bedside

Cited by 10 publications

References 126 publications

Anti-neoplastic Potential of Flavonoids and Polysaccharide Phytochemicals in Glioblastoma

Anti-neoplastic Potential of Flavonoids and Polysaccharide Phytochemicals in Glioblastoma

Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Screening of Antioxidative and Antiproliferative Activities of Crude Polysaccharides Extracted from Six Different Plants

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