Polysensitization to aeroallergens and food in eosinophilic esophagitis in a pediatric population

Plaza-Martin, Ana María; Jiménez‐Feijoo, Rosa; Andaluz, Consuelo; Giner-Muñoz, M.T.; Martín-Mateos, María Anunciación; Piquer-Gibert, M.; Sierra-Martínez, J.I.

doi:10.1016/s0301-0546(07)70227-6

Cited by 26 publications

(12 citation statements)

References 8 publications

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“…In order to maintain a large pool of patients in the subcohort, we also did not attempt to match the subcohort to the general EoE population for age and gender. In our study, 44.7% patients had AR, 27.1% had asthma, 25.2% had AD, and 16.9% had food allergies, which was comparable to rates reported in the published literature . The results from our study are therefore aligned with overall published estimates and confirm a greater‐than‐average prevalence of asthma, AR, and food allergies in patients with EoE, as the overall U.S. prevalence of these conditions was estimated at 14%, 10%, and 8.9%, respectively …”

Section: Discussionsupporting

confidence: 90%

Prevalence of atopic disease in patients with eosinophilic esophagitis

Benninger

Strohl

Holy

et al. 2017

Int Forum Allergy Rhinol

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Section: Discussionsupporting

confidence: 90%

Prevalence of atopic disease in patients with eosinophilic esophagitis

Benninger

Strohl

Holy

et al. 2017

Int Forum Allergy Rhinol

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“…For example, in an initial case report highlighting this association, a patient’s esophageal eosinophil count was markedly increased during pollen seasons and normalized when the pollen was not present (42). Since then, larger studies have confirmed a relationship between aeroallergens and eosinophilic esophagitis in humans (41, 43), a relationship that has been established as causal in a murine model of EoE (44, 45). Seasonal variation has also been reported in multiple studies of EoE, a pattern that also argues for possible environmental triggers (6, 9, 40, 41, 46, 47).…”

Section: Discussionmentioning

confidence: 94%

Prevalence of Esophageal Eosinophilia Varies by Climate Zone in the United States

Hurrell

Genta

Dellon

2012

American Journal of Gastroenterology

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Objectives The epidemiology of eosinophilic esophagitis (EoE) is rapidly evolving, and differences in climate could impact the prevalence of EoE. We aimed to examine the association between esophageal eosinophilia and climate zones in the U.S. Methods This was a cross-sectional study of esophageal biopsies from 2008 to 2010 in a large U.S. pathology database. Cases were patients with esophageal eosinophilia; controls had normal esophageal biopsies. A Köppen-Geiger (K-G) climate class was assigned to each patient, and the association between case-control status and the main K-G climate type (tropical, arid, temperate, or cold) was assessed. Results A total of 233,649 patients were included, 71,948 (30.8%) with normal esophageal biopsies and 9,995 (4.3%) with esophageal eosinophilia. Using the temperate zone as the referent and after multivariable analysis, the odds of esophageal eosinophilia were highest in the cold climate zone (OR = 1.39, 95% CI: 1.34-1.47), compared to the tropical zone (OR = 0.87; 95% CI: 0.71-10.8) and the arid zone (OR = 1.27; 95% CI: 1.19-1.36). Increased likelihood of EoE was also associated with increasing odds of being in the cold climate zone. Compared to patients with normal esophageal biopsies, patients with dysphagia, a clinical suspicion of EoE, no reflux or Barrett’s esophagus, esophageal eosinophilia, and eosinophilic microabscesses had the highest adjusted odds of being in a cold climate zone (OR 2.02; 1.78-2.28). Conclusions Esophageal eosinophilia differs significantly between K-G climate zones, with the highest prevalence in the cold and arid zones. Geographic and climate patterns may help identify candidate antigens characteristic to high-prevalence areas to be targeted for future investigation.

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“…Interesting data from Plaza-Martín et al [35] emphasized that all patients with EE have symptoms of allergic respiratory disease prior to receiving a diagnosis of EE with poly-sensitization (aeroallergens and food allergens): food sensitization in this series most often corresponded to legumes, which have a cross-reaction with pollens.…”

Section: Dietary Intervention In Eosinophilic Esophagitismentioning

confidence: 87%

Eosinophilic esophagitis: management and pharmacotherapy

Angelis

Morino

Pane

et al. 2008

Expert Opinion on Pharmacotherapy

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Eosinophilic esophagitis represents the most debated disease of the last 10 years, too often speculated or overestimated and certainly well known and examined. The aim of this study was to summarize the recent therapeutic trends in order to show persistent doubts regarding several debated therapies. The study combined the most recent international literature and the authors' daily experience to define the scope of the review, with limits caused by a lack of available randomized studies between dietetic and pharmacological treatment. It was concluded that eosinophilic esophagitis is an immunoallergic disease that is generally caused by identifiable food and environmental allergens although, in a minority of cases, the etiological trigger remains undetermined. Therapy usually fights the responsible agents, but sometimes they are not resolved. A need for more pathogenetically driven treatments is invoked.

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Polysensitization to aeroallergens and food in eosinophilic esophagitis in a pediatric population

Cited by 26 publications

References 8 publications

Prevalence of atopic disease in patients with eosinophilic esophagitis

Prevalence of atopic disease in patients with eosinophilic esophagitis

Prevalence of Esophageal Eosinophilia Varies by Climate Zone in the United States

Eosinophilic esophagitis: management and pharmacotherapy

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