Polyserositis as a Rare Component of Polyglandular Autoimmune Syndrome Type Ii

Abstract

SUMMARYPolyglandular autoimmune (PGA) syndromes (types I and II) may affect various endocrine and non‐endocrine organs in the body. In the commoner PGA type II, primary adrenal insufficiency, autoimmune thyroid disease and type I diabetes mellitus are the most frequent manifestations. Serositis with pericardial or pleural involvement is not a well known component of the disease. Here, we report a 21‐year‐old man who first presented with a pleuropericardial effusion and Graves' disease, and who then developed type I diabetes mellitus.

Polyserositis caused by tuberculosis in a young female patient with hypothyroidism: A diagnostic challenge

“…6 Certain case reports have shown that endocrine disorders, including hypothyroidism, can also cause polyserositis. 2 A diagnostic challenge is faced when there are two or more possible causes of polyserositis, like in our case, where there were evidences of both TB and hypothyroidism. In such cases, microbiologic tests, such as GeneXpert, remain the most important tools to confirm TB as the cause of the polyserositis.…”

“…1 It has numerous causes and frequently occurs in neoplasia, autoimmune disorders, endocrine conditions like hypothyroidism, and infectious diseases like tuberculosis (TB). 2,3 According to a systemic review of 114 cases, the most common causes of polyserositis were neoplasia (30; 26.3%), autoimmune illnesses (19; 16.7%), and infections (16; 12.2%). 4 Serosal TB is a common extrapulmonary TB presentation, particularly in areas where the disease is highly endemic.…”