2009
DOI: 10.1002/9780470538357.ch14
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Polysiloxane Coatings Containing Tethered Antimicrobial Moieties

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Cited by 3 publications
(5 citation statements)
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“…Researchers at the Center for Nanoscale Science and Engineering of the North Dakota State University have also been using CHT methods to investigate polysiloxane-based coatings possessing tethered quaternary ammonium salt (QAS) groups for combating marine biofouling. The rationale for incorporating QAS groups into the polysiloxane matrix was based on the well-known inhibitory effect of QASs toward many microorganisms including Gram-positive and Gram-negative bacteria, yeasts, and molds. The positively charged nitrogen atom of QASs can bind to the negatively charged cell wall of a microorganism resulting in disruption of the integrity of the cell wall and, as a result, cell death. , By tethering QASs groups to the polymer matrix, it was thought that an antimicrobial effect could be obtained without causing harm to the environment, which is stark contrast to current antifouling coatings that function by releasing copious amounts of biocide into the ocean . The rationale for utilizing a polysiloxane-based coating was based on the good fouling-release properties previously observed for polysiloxanes .…”
Section: Materials Development Examplesmentioning
confidence: 99%
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“…Researchers at the Center for Nanoscale Science and Engineering of the North Dakota State University have also been using CHT methods to investigate polysiloxane-based coatings possessing tethered quaternary ammonium salt (QAS) groups for combating marine biofouling. The rationale for incorporating QAS groups into the polysiloxane matrix was based on the well-known inhibitory effect of QASs toward many microorganisms including Gram-positive and Gram-negative bacteria, yeasts, and molds. The positively charged nitrogen atom of QASs can bind to the negatively charged cell wall of a microorganism resulting in disruption of the integrity of the cell wall and, as a result, cell death. , By tethering QASs groups to the polymer matrix, it was thought that an antimicrobial effect could be obtained without causing harm to the environment, which is stark contrast to current antifouling coatings that function by releasing copious amounts of biocide into the ocean . The rationale for utilizing a polysiloxane-based coating was based on the good fouling-release properties previously observed for polysiloxanes .…”
Section: Materials Development Examplesmentioning
confidence: 99%
“…Because of the antimicrobial activity exhibited by some of the QAS-functional PDMS coatings, the scope of the potential applications for these coatings was broadened to include biomedical applications, such as catheters, contact lenses, ophthalmic lenses, and medical implants. In general, polysiloxanes have been shown to exhibit biocompatibility, and the ability to introduce antimicrobial properties via the incorporation of covalently bound QAS groups may enable the production of devices that reduce the occurrence of infection. In addition, unlike coatings that release an antibiotic to inhibit infection, these coatings should have a lower potential for producing resistant strains of microorganisms. , A study was conducted by Majumdar et al that involved the development of structure–antimicrobial relationships in which 20 different TMS-QASs were synthesized and incorporated into polysiloxane coatings to produce 60 unique coating compositions.…”
Section: Materials Development Examplesmentioning
confidence: 99%
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“…Quaternary ammonium compounds (QACs) are widely used as antimicrobial agents to inhibit microbial growth [12][13][14][15]. The antimicrobial activity provided by QACs results from both ionic and hydrophobic interactions between the QAC and components of the microbial cell wall that leads to cell death or malfunction in cellular processes [16][17][18].…”
Section: Introductionmentioning
confidence: 99%
“…The best example of such biomimetic antifouling coating is Sharklet AF ™ which was inspired by the microtopography of the shark skin (Bechert et al, 2000). The C18 coatings with high levels of nano-roughness were found to inhibit the settlement of Ulva spores and its antifouling effect was shown to exceed that of a commercially available fouling release coating (Majumdar et al, 2008). Superhydrophobic coatings with nano-scaled roughness prevented the settlement of major micro-and macro-fouling species (Scardino et al, 2009).…”
Section: Introductionmentioning
confidence: 99%