Polysiloxanes containing thermally stable chiral amide side-chains for capillary gas and supercritical fluid chromatography

Bradshaw, Jerald S.; Aggarwal, Sunil; Rouse, Christine A.; Tarbet, Bryon J.; Markides, Karin E.; Lee, Milton L.

doi:10.1016/s0021-9673(01)81759-3

Cited by 37 publications

(2 citation statements)

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“…40 % for the product described previously [9,15]. We found, however, no change in the properties of the resulting Chirasil-Dex stationary phases, as there seems to be no measurable contribution to the cross-linking properties of the approximately 30 % dioctenylated cyclodextrin contained in previous batches of Chirasil-Dex.…”

Section: Resultsmentioning

confidence: 46%

“…Sep. 5, 11-22 (1993) H,PtCl,-catalyzed hydrosilylation [8,9], in analogy to the synthesis of Chirasil-Val-Nova [ 101 and Chirasil-Metal [ 113. We recently described in detail the advantages of Chirasil-Dex as compared to the original dissolved stationary phase (i. e., permethylated /3-cyclodextrin in OV-1701) for more than 100 racemates [12].…”

Section: Introductionmentioning

confidence: 99%

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Enantiomeric separation by GC on chirasil‐dex: Systematic study of cyclodextrin concentration, polarity, immobilization, and column stability

Jung

Schurig

1993

J Microcolumn Separations

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Abstract. Polysiloxane-anchored permethylated 6-cyclodextrin (Chirasil-Dex) was used for enantiomeric separation by GC. Four types of Chirasil-Dex, containing up to 36 % permethylated 0-cyclodextrin by weight, were synthesized and compared with 10 % permethylated P-cyclodextrin dissolved in OV-1701. The influence of the cyclodextrin weight percentage on the chiral separation factor CY and on polarity, as expressed by the Kovats indices, was studied. The chiral separation factors a did not increase significantly above a threshold of -30 % permethylated P-cyclodextrin by weight. The plots of a vs.weight percentage depend on the complexation strength of the chiral solutes, as do the Kovats indices; for weakly complexing solutes, changes in the cyclodextrin concentration result in larger changes in a, but in less pronounced changes in the Kovats indices, as compared to strongly complexing solutes. Column performances were investigated for immobilized and nonimmobilized stationary phases. As expected, immobilization properties were found to depend on the content of Si-H groups in the polysiloxane backbone. Immobilized columns exhibited a much better long-term stability of all chromatographic variables investigated.

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Section: Resultsmentioning

confidence: 46%