Polysomnographic and pulmonary function changes in patients with sleep problems after septoplasty with turbinectomy

Mandour, Yasser; Youssef, Shaimaa M.A; Moussa, Hany H.

doi:10.1016/j.amjoto.2018.12.003

Cited by 7 publications

(14 citation statements)

References 20 publications

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“…The same results were reported in previous studies [16,[20][21][22]. Cassisi et al [21] reported that nasal packing caused a significant decrease in PaO 2 , but it had little effect on PaCO 2 , and that low PO 2 returned to normal after the pack had been removed.…”

Section: Discussionsupporting

confidence: 84%

“…The results of this study revealed that patients with nasal obstruction had impaired pulmonary function tests (decreased FVC, FEV1) which are significantly improved postoperative (Table 3). Previous studies [15,16] reported lower FEV1, FVC in patients with the nasal obstruction which improved following surgery. However; Yiğit et al [12] reported a small non-significant reduction in the values of FEV1, FVC in patients with nasal packing.…”

Section: Discussionmentioning

confidence: 78%

“…Saxena et al [22] demonstrated a significant increase in partial arterial oxygen saturation percentages, as well as peak and forced expiratory flow speed in a group of patients with deviated nasal septum 1 month after the surgical correction. Mandour et al [16] reported statistically significant improvement in nocturnal oxygen in patients with nasal obstruction after surgery.…”

Section: Discussionmentioning

confidence: 97%

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Elimination of nasal obstruction improves pulmonary functions and oxygenation

2021

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Background Nasal obstruction is a significant medical problem. This study aimed to examine the effect of nasal obstruction and nasal packing on arterial blood gases and pulmonary function indices, and the impact of the elimination of nasal obstruction on preoperative values. Results The mean age of the study population was 26.6 ± 10.1 years, males represented 50.8%. Spirometric indices showed statistically significant improvement (preoperative forced expiratory volume in 1st second 66.9 ± 13.9 vs 79.6 ± 14.9 postoperative and preoperative forced vital capacity 65.5 ± 12.7 vs 80.4 ± 13.8 postoperative). Oxygen saturation was significantly lower during nasal packing (95.6 ± 1.6 preoperative vs 94.7 ± 2.8 with nasal pack), and significant improvement (97.2 ± 1.4) was observed after removal of the nasal pack. Nasal obstruction scores significantly improved. Conclusion The results of this study indicate that either simple nasal obstruction or nasal packing may cause hypoxemia and abnormalities in lung function tests. Hypoxemia was more evident with nasal packing.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 97%

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Elimination of nasal obstruction improves pulmonary functions and oxygenation

2021

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“…Nasal septum deviation (NSD) that describes a non-straight, deformed nasal septum is a common abnormality and can be observed in 80% of the population ( Serifoglu et al, 2017 ). NSD might be inconspicuous but frequently is associated with various degrees of nasal airway obstruction resulting in Sleep Disordered Breathing (SDB) ( Wang et al, 2016 ; Alsufyani et al, 2017 ; Mandour et al, 2019 ). Congenitally acquired deviation frequently develops during time of rapid midfacial growth and is associated with reduced midfacial growth and a strong predisposition for SDB ( D’Ascanio et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Nasal Septum Deviation as the Consequence of BMP-Controlled Changes to Cartilage Properties

Baddam

Young

Dunsmore

et al. 2021

Front. Cell Dev. Biol.

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The nasal septum cartilage is a specialized hyaline cartilage important for normal midfacial growth. Abnormal midfacial growth is associated with midfacial hypoplasia and nasal septum deviation (NSD). However, the underlying genetics and associated functional consequences of these two anomalies are poorly understood. We have previously shown that loss of Bone Morphogenetic Protein 7 (BMP7) from neural crest (BMP7ncko) leads to midfacial hypoplasia and subsequent septum deviation. In this study we elucidate the cellular and molecular abnormalities underlying NSD using comparative gene expression, quantitative proteomics, and immunofluorescence analysis. We show that reduced cartilage growth and septum deviation are associated with acquisition of elastic cartilage markers and share similarities with osteoarthritis (OA) of the knee. The genetic reduction of BMP2 in BMP7ncko mice was sufficient to rescue NSD and suppress elastic cartilage markers. To our knowledge this investigation provides the first genetic example of an in vivo cartilage fate switch showing that this is controlled by the relative balance of BMP2 and BMP7. Cellular and molecular changes similar between NSD and knee OA suggest a related etiology underlying these cartilage abnormalities.

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“…All patients presented with nasal obstruction and 80% of them had mouth breathing, which was suggestive of severe obstruction. Nasal obstruction secondary to the deviated nasal septum and turbinate hypertrophy was identified as a risk factor for sleep disorders by Mandour et al [8] and they observed that polysomnography parameters improved following nasal surgeries in addition to improvement in the pulmonary function tests. Morinaga et al [9] found that nasal surgeries improves apnoea -hypopnoea index besides nocturnal oxygenation in patients with sleep apnoea.…”

Section: Discussionmentioning

confidence: 99%

Can Upper Airway Surgeries Improve Lower Airway Function ? A Prospective Study

Arifa

Nayana

Irfan

2021

Indian J Otolaryngol Head Neck Surg

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Deviated nasal septum and turbinate hypertrophy are the most common causes for nasal obstruction, which compromise nasal airflow and increases airway resistance. These conditions can further reduce the airflow to lung, which will affect the lung volume and function subsequently reduces the exercise tolerance. The present study aimed to evaluate the impact of upper airway surgeries like septoplasty and turbinoplasty on lower airway functions using simple tests like spirometry and 6 min walking test (6mWt). This research was a prospective study. There were 88 subjects in the study who completed follow up. Spirometry and 6mWt was performed 1 day before and 1 month after surgery in all subjects. Mean preoperative and postoperative values of spirometry (forced vital capacity (FVC),forced expiratory volume in 1 s (FEV1), forced expiratory volume in 1 s/ forced vital capacity (FEV1/FVC), peak expiratory flow rate (PEFR) and 6mWt (systolic blood pressure, diastolic blood pressure, heart rate and oxygen saturation) parameters were compared and analyzed. Percentage of improvement of each parameter was compared with the type of surgery, side of obstruction, age of the patient and duration of symptom. Spirometry showed statistically significant improvement in all 4 parameters after surgery in 86 subjects. 6mWt showed statistically significant improvement in SBP and SpO2 and there was no significant improvement in DBP and HR. We also observed that improvement in parameters was irrespective of age and duration of symptoms. So this study concludes that airway narrowing nasal diseases can compromise lower airway function.

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Polysomnographic and pulmonary function changes in patients with sleep problems after septoplasty with turbinectomy

Cited by 7 publications

References 20 publications

Elimination of nasal obstruction improves pulmonary functions and oxygenation

Elimination of nasal obstruction improves pulmonary functions and oxygenation

Nasal Septum Deviation as the Consequence of BMP-Controlled Changes to Cartilage Properties

Can Upper Airway Surgeries Improve Lower Airway Function ? A Prospective Study

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