Polysomnographic Measurement of Sleep Duration and Bodily Pain Perception in the Sleep Heart Health Study

Weingarten, Jeremy A.; Dubrovsky, Boris; Basner, Robert C.; Redline, Susan; George, Liziamma; Lederer, David J.

doi:10.5665/sleep.6026

Cited by 16 publications

(9 citation statements)

References 42 publications

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“…13,14,36 A recent population-based study also showed that short total sleep times are associated with reports of moderate to severe pain. 45 Further, experimental data have demonstrated that sleep restriction reduces pain thresholds, which supports the observed relationships between insufficient sleep and increased pain sensitivity in experimental and population-based studies. 18,20,24,26,31,33,36,41 Improving sleep quantity and/or quality also reduces pain sensitivity in healthy participants 32 and pain severity in chronic pain patients.…”

Section: Introductionsupporting

confidence: 54%

Chronic exposure to insufficient sleep alters processes of pain habituation and sensitization

Simpson

Scott-Sutherland

Gautam

et al. 2017

Pain

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Chronic pain conditions are highly comorbid with insufficient sleep. While the mechanistic relationships between the 2 are not understood, chronic insufficient sleep may be 1 pathway through which central pain-modulatory circuits deteriorate, thereby contributing to chronic pain vulnerability over time. To test this hypothesis, an in-laboratory model of 3 weeks of restricted sleep with limited recovery (5 nights of 4-hour sleep per night followed by 2 nights of 8-hour sleep per night) was compared with 3 weeks of 8-hour sleep per night (control protocol). Seventeen healthy adults participated, with 14 completing both 3-week protocols. Measures of spontaneous pain, heat-pain thresholds, cold-pain tolerance (measuring habituation to cold over several weeks), and temporal summation of pain (examining the slope of pain ratings during cold water immersion) were assessed at multiple points during each protocol. Compared with the control protocol, participants in the sleep-restriction protocol experienced mild increases in spontaneous pain (P < 0.05). Heat-pain thresholds decreased after the first week of sleep restriction (P < 0.05) but normalized with longer exposure to sleep restriction. By contrast, chronic exposure to restricted sleep was associated with decreased habituation to, and increased temporal summation in response to cold pain (both P < 0.05), although only in the past 2 weeks of the sleep-restriction protocol. These changes may reflect abnormalities in central pain-modulatory processes. Limited recovery sleep did not completely resolve these alterations in pain-modulatory processes, indicating that more extensive recovery sleep is required. Results suggest that exposure to chronic insufficient sleep may increase vulnerability to chronic pain by altering processes of pain habituation and sensitization.

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Section: Introductionsupporting

confidence: 54%

Chronic exposure to insufficient sleep alters processes of pain habituation and sensitization

Simpson

Scott-Sutherland

Gautam

et al. 2017

Pain

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“…Haack et al [30] conducted a study and found that activation of the prostaglandin E2 (PGE2) system appeared to be a potential mediator of increased spontaneous pain in response to insufficient sleep. Weingarten et al conducted a population-based study [31], and the authors concluded that short TSTs were associated with reports of moderate to severe pain. Odegard et al [32] concluded that sleep restriction reduced the central nervous system (CNS) response to pain, while some of the subjective pain measures indicated hyperalgesia.…”

Section: Discussionmentioning

confidence: 99%

Preoperative sleep quality affects postoperative pain and function after total joint arthroplasty: a prospective cohort study

Luo

Wang

et al. 2019

J Orthop Surg Res

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BackgroundThe relationship between preoperative sleep quality and postoperative clinical outcomes after total joint arthroplasty (TJA) is unclear. We performed a prospective cohort study to determine whether preoperative sleep quality was correlated with postoperative outcomes after TJA.MethodsIn this prospective cohort study, 994 patients underwent TJA. Preoperative sleep measures included scores on the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS), and a ten-point sleep quality scale. The primary study outcome measured was the visual analog scale (VAS) pain score to 12 weeks postoperation. The consumption of analgesic rescue drugs (oxycodone and parecoxib) and postoperative length of stay (LOS) were recorded. We also measured functional parameters, including range of motion (ROM), Knee Society Score (KSS), and Harris hip score (HHS).ResultsThe mean age for total knee and hip arthroplasties was 64.28 and 54.85 years, respectively. The PSQI scores were significantly correlated with nocturnal and active pain scores and ROM and functional scores from postoperative day 1 (POD1) to POD3. In addition, significant correlation was noted between the correlation between the active pain scores and ESS scores in the TKA group at postoperative 3 months. The consumption of analgesics after joint arthroplasty was significantly correlated with the PSQI scores. Moreover, significant correlations were noted between the sleep parameters and postoperative length of hospital stay (LOS).ConclusionPreoperative sleep parameters were correlated with clinical outcomes (i.e., pain, ROM, function, and LOS) after TJA. Clinicians should assess the sleep quality and improve it before TJA.

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“…37,54 Apart from problems with sleep initiation and maintenance, sleep-disordered breathing, 2 restless legs syndrome, 27 and narcolepsy, 17 are also more common among people with pain disorders than in pain-free individuals, although there is little evidence that sleep architecture differs in people with pain. 6,57 Longitudinal studies show that although disturbed sleep and pain have bidirectional relationships, the effect of sleep disturbance on pain development is greater than the effect of pain on sleep disturbance. 21 Moreover, the extent of sleep disturbance predicts sensitivity to experimental pain 52 and intensity of clinical pain 1 in a dose-response manner.…”

mentioning

confidence: 99%

Causal Mediation in the Development of Painful Temporomandibular Disorder

Sanders

Akinkugbe

Fillingim

et al. 2017

The Journal of Pain

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We explored causal mediation of sleep quality and perceived stress in development of painful temporomandibular disorder (TMD). Sleep quality and perceived stress were assessed at baseline and quarterly intervals thereafter in 2,737 initially TMD-free adults in the Orofacial Pain Prospective Evaluation and Risk Assessment study (OPPERA) prospective cohort study. During follow-up, incident TMD cases were classified using research diagnostic criteria. Mediation analysis was conducted using a weighted Cox proportional hazards regression model that estimated hazard ratios (HRs) and 95% confidence limits (CL) of first-onset TMD. Models determined whether: 1) poor sleep quality during follow-up mediated the effect of baseline perceived stress on first-onset TMD, and 2) perceived stress during follow-up mediated the effect of baseline poor sleep quality on first-onset TMD. In both analyses, the total effect was decomposed into natural direct and indirect effects. Poor baseline sleep quality led to heightened perceived stress that then contributed to TMD development. When the total effect of poor sleep quality (HR = 2.10, CL = 1.76, 2.50) was decomposed, 34% of its effect was mediated by perceived stress (indirect effect HR = 1.29, CL = 1.06, 1.58). The effect of perceived stress on first-onset TMD was not mediated by sleep quality. Improving sleep may avert escalation of stress, limiting effects of both factors on TMD development.

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Polysomnographic Measurement of Sleep Duration and Bodily Pain Perception in the Sleep Heart Health Study

Abstract: Shorter TST among all subjects and shorter SWS time in men was associated with "moderate to severe pain." REM sleep time was not associated with bodily pain perception in this cohort.

Cited by 16 publications

References 42 publications

Chronic exposure to insufficient sleep alters processes of pain habituation and sensitization

Chronic exposure to insufficient sleep alters processes of pain habituation and sensitization

Preoperative sleep quality affects postoperative pain and function after total joint arthroplasty: a prospective cohort study

Causal Mediation in the Development of Painful Temporomandibular Disorder

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