Polysomnography During Withdrawal with Clomethiazole or Placebo in Alcohol Dependent Patients - A Double-Blind and Randomized Study

Gann, Horst; Feige, Bernd; Cloot, O; Wasen, H Van; Zinzgraf, D; Hohagen, Fritz; Riemann, Dieter

doi:10.1055/s-2004-832597

Cited by 15 publications

(7 citation statements)

References 21 publications

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“…In previous work, we described in detail the sleep of alcohol-dependent patients at the beginning and during the course of abstinence (Gann et al, 1997(Gann et al, , 1998(Gann et al, , 2001a(Gann et al, , 2001b(Gann et al, , 2002(Gann et al, , 2004a(Gann et al, , 2004bHornyak et al, 2005). These studies revealed that during early abstinence, the sleep of alcohol-dependent patients is characterized by disturbed sleep continuity (decreased sleep efficiency, prolonged sleep latency, increased number of awakenings), decreases in SWS, and increased REM sleep pressure (including a shortening of REM latency, increased REM density, and heightened amounts of REM sleep).…”

Section: Discussionmentioning

confidence: 98%

Effects of Alcohol on Polysomnographically Recorded Sleep in Healthy Subjects

Feige

Gann

Brueck

et al. 2006

Alcoholism Clin & Exp Res

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Owing to the small sample size, the results of this study need to be interpreted with caution. Short-term moderate alcohol consumption (BAL 0.03%) did not significantly alter objective or subjective parameters of sleep. Higher doses of alcohol resulting in a BAL level of 0.10% immediately before going to bed mainly influenced sleep in the first half of the night, resembling the effects of a short-acting hypnotic drug, including a suppression of phasic aspects of REM sleep (REM density). Interestingly, analysis of the latter part of these nights indicated the immediate presence of withdrawal effects (increased light sleep). No statistically significant effects on sleep parameters were observable during the 2 nights of withdrawal from alcohol at the higher BAL. Interpreted carefully, our data indicate that negative effects on sleep occur already with short-term use of alcohol at doses of BAL of 0.10%, despite hypnotic-like effects during the first hours of sleep, especially during the latter part of the night.

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Section: Discussionmentioning

confidence: 98%

Effects of Alcohol on Polysomnographically Recorded Sleep in Healthy Subjects

Feige

Gann

Brueck

et al. 2006

Alcoholism Clin & Exp Res

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“…It could be related to the decrement in performance that accompanies poor sleep contributes to psychological and/or social pressures to begin drinking again, or that recovered alcoholics with insomnia actually return to drinking as a form of selfmedication (Brower, 2003), but scant support exists for either of these hypotheses. A number of investigators have begun to incorporate strategies for improving sleep in abstinent alcoholics with the hope that this will decrease relapse drinking (Allen et al, 1977;Arnedt et al, 2007;Gann et al, 2004;Hornyak et al, 2004;Karam-Hage and Brower, 2000;Staner et al, 2006;Zarcone and Hoddes, 1975). Obviously, improvements in this potential therapeutic intervention could be made if a better understanding of alcohol induced sleep pathologies was available.…”

Section: Discussionmentioning

confidence: 99%

Dose–response study of chronic alcohol induced changes in sleep patterns in rats

2008

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The goal of the present study was to determine an optimum exposure regimen for alterations in sleep induced by chronic alcohol treatments in rats. We used two different exposure routes (alcohol in water and alcohol in liquid diet at two different doses in each regimen (6% and 12% alcohol in water and 3% and 6% alcohol in liquid diet)). All treatments were for 6 weeks. We found the effects of the 6% and 12% in water and 3% in liquid diet to be very similar; all three produced increases in slowwave sleep (SWS) only in the dark period with no changes in rapid-eye-movement sleep (REMS). On the other hand 6% alcohol in liquid diet caused much more dramatic changes, with alterations in both SWS and REMS in both the dark and light periods. These animals spent less time in SWS and REMS during the light period but more time in SWS and REMS in the dark period. Additionally, the variation of slow-wave amplitude (SWA) across day and night in this group of alcoholic animals is blunted with the loss of the peak of SWA at the beginning of light onset compared to the other groups. We conclude that future alcohol treatment regimens used to investigate the effects of alcohol on sleep in adult rats should use an exposure protocol of at least 6 weeks with 6% alcohol in liquid diet.

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“…These inverse effects were similar in magnitude, each modulating sleep onset by 4–5 min per drink. This raises the possibility that the delayed negative impact of alcohol use on sleep onset may parallel its positive same‐day impact, perhaps similar to the rapid eye movement sleep rebound phenomenon documented following nights of abstinence from other sleep‐promoting drugs (Feige et al ., ; Gann et al ., ). However, weekly alcohol use was not significantly associated with insomnia parameters in this study; thus, there seems to be something unique about drinking at the daily level that accounts for change in sleep onset.…”

Section: Discussionmentioning

confidence: 97%

Dynamic daily associations between insomnia symptoms and alcohol use in adults with chronic pain

Miller

Chan

Boissoneault

et al. 2017

Journal of Sleep Research

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Individuals with chronic pain are at risk for sleep disruption and heavy alcohol use, yet the daily associations between these behaviours are not well characterized. This study aimed to determine the extent to which alcohol use affects insomnia symptoms and vice versa in adults reporting symptoms of chronic pain. Participants were 73 individuals (93% women) reporting alcohol use in addition to symptoms of insomnia and chronic pain. They completed daily diaries assessing insomnia symptoms and alcohol use for 14 days. Multilevel modelling was used to evaluate the bidirectional associations between alcohol use and insomnia symptoms at the daily level. Consistent with laboratory-based research, alcohol use was associated with decreased sleep-onset latency the same night but increased sleep-onset latency 2 nights later. Specifically, for every alcoholic drink consumed, time to sleep onset decreased by 5.0 min in the same night but increased by 4.3 min 2 nights later. Alcohol use was not significantly associated with subsequent wake after sleep onset or total sleep time, and insomnia symptoms were not significantly associated with subsequent alcohol use. To our knowledge, these data provide the first evidence that alcohol use negatively affects insomnia symptoms up to 2 days post-consumption in patients reporting symptoms of insomnia and chronic pain. Findings suggest that one drink will have minimal impact on sleep, but heavier drinking (e.g. four-five drinks) may have a clinically significant impact (16-25-min increase in sleep-onset latency). Future studies may assess alcohol use as a point of intervention within this population.

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Polysomnography During Withdrawal with Clomethiazole or Placebo in Alcohol Dependent Patients - A Double-Blind and Randomized Study

Cited by 15 publications

References 21 publications

Effects of Alcohol on Polysomnographically Recorded Sleep in Healthy Subjects

Effects of Alcohol on Polysomnographically Recorded Sleep in Healthy Subjects

Dose–response study of chronic alcohol induced changes in sleep patterns in rats

Dynamic daily associations between insomnia symptoms and alcohol use in adults with chronic pain

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