Polysorbate-80 surface modified nano-stearylamine BQCA conjugate for the management of Alzheimer's disease

Chintamaneni, Pavan Kumar; Krishnamurthy, Praveen Thaggikuppe

doi:10.1039/d1ra00049g

Cited by 7 publications

(4 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animal model results showed that drug uptake in the brain increased four-fold for PBCA NPs coated with 1% PS 80 compared to free drugs. Several studies have demonstrated that PS 80-coated NPs can improve drug accumulation in the brain [124][125][126][127][128][129][130][131]. It has been reported that brain targeting of PS 80-coated NPs is closely associated with the interaction between PS 80 coating and brain microvessel endothelial cells [132].…”

Section: Ps-coated Nps For Efficient Bbb Transportmentioning

confidence: 99%

Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy

et al. 2021

View full text Add to dashboard Cite

Polysorbates (PSs) are synthetic nonionic surfactants consisting of polyethoxy sorbitan fatty acid esters. PSs have been widely employed as emulsifiers and stabilizers in various drug formulations and food additives. Recently, various PS-based formulations have been developed for safe and efficient drug delivery. This review introduces the general features of PSs and PS-based drug carriers, summarizes recent progress in the development of PS-based drug formulations, and discusses the physicochemical properties, biological safety, P-glycoprotein inhibitory properties, and therapeutic applications of PS-based drug formulations. Additionally, recent advances in brain-targeted drug delivery using PS-based drug formulations have been highlighted. This review will help researchers understand the potential of PSs as effective drug formulation agents.

show abstract

Section: Ps-coated Nps For Efficient Bbb Transportmentioning

confidence: 99%

Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Current applications of surfactants in the manufacture of NP for biomedical applications seek a vectorization phenomenon to facilitate drug release at receptor sites [12]. In this regard, the participation of surfactants represents a multifunctional ingredient that usually requires adsorption by covalent crosslinking to guarantee better performance in biological pathways [13,14].…”

Section: Introductionmentioning

confidence: 99%

Non-Ionic Surfactants for Stabilization of Polymeric Nanoparticles for Biomedical Uses

et al. 2021

View full text Add to dashboard Cite

Surfactants are essential in the manufacture of polymeric nanoparticles by emulsion formation methods and to preserve the stability of carriers in liquid media. The deposition of non-ionic surfactants at the interface allows a considerable reduction of the globule of the emulsion with high biocompatibility and the possibility of oscillating the final sizes in a wide nanometric range. Therefore, this review presents an analysis of the three principal non-ionic surfactants utilized in the manufacture of polymeric nanoparticles; polysorbates, poly(vinyl alcohol), and poloxamers. We included a section on general properties and uses and a comprehensive compilation of formulations with each principal non-ionic surfactant. Then, we highlight a section on the interaction of non-ionic surfactants with biological barriers to emphasize that the function of surfactants is not limited to stabilizing the dispersion of nanoparticles and has a broad impact on pharmacokinetics. Finally, the last section corresponds to a recommendation in the experimental approach for choosing a surfactant applying the systematic methodology of Quality by Design.

show abstract

“…They found that PS 80-NPs exhibited the highest neural cellular uptake and BBB permeability . Additionally, PS 80 has other advantages such as low cost, good stability, and minimal immunogenicity and has been approved to be used in some pharmaceutical and food industries. − However, to our knowledge, PS 80-coated NPs have never been used to transfer AMF to the brain for RIBI prophylaxis. Our initial screening studies demonstrated that DAPP NPs exhibited good neural cellular uptake.…”

Section: Discussionmentioning

confidence: 99%

Amifostine-Loaded Nanocarrier Traverses the Blood–Brain Barrier and Prevents Radiation-Induced Brain Injury

Zhao

Cheng

Gui

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Radiation-induced brain injury (RIBI) is a severe, irreversible, or even life-threatening cerebral complication of radiotherapy in patients with head and neck tumors, and there is no satisfying prevention and effective treatment available for these patients. Amifostine (AMF) is a well-known free radical scavenger with demonstrated effectiveness in preventing radiation-induced toxicity. However, the limited permeability of AMF across the blood–brain barrier (BBB) when administered intravenously reduces the effectiveness of AMF in preventing RIBI. Herein, we construct a nanoparticle (NP) platform for BBB delivery of AMF. AMF is conjugated with 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-n-[poly(ethylene glycol)]-hydroxy succinamide [DSPE-PEG-NHS, PEG M 2000], and the product is DSPE-PEG-AMF. Then, the nanoparticles (DAPP NPs) were formed by self-assembly of poly(lactic-co-glycolic acid) (PLGA), DSPE-PEG-AMF, and polysorbate 80 (PS 80). PEG shields the nanoparticles from blood clearance by the reticuloendothelial system and lengthens the drug circulation time. PS 80 is used to encapsulate nanoparticles for medication delivery to the brain. The results of our study showed that DAPP NPs were able to effectively penetrate the blood–brain barrier (BBB) in healthy C57BL/6 mice. Furthermore, in a well-established mouse model of X-knife-induced brain injury, treatment with DAPP NPs (corresponding to 250 mg/kg AMF) was found to significantly reduce the volume of brain necrosis compared to mice treated with AMF (250 mg/kg). Importantly, the use of DAPP NPs was also shown to significantly mitigate the effects of radiation-induced neuronal damage and glial activation. This work presents a convenient brain-targeted AMF delivery system to achieve effective radioprotection for the brain, providing a promising strategy with tremendous clinical translation potential.

show abstract

Polysorbate-80 surface modified nano-stearylamine BQCA conjugate for the management of Alzheimer's disease

Abstract: Acetylcholinesterase (AChE) inhibitors such as donepezil, galantamine and rivastigmine are used for the management of dementia in Alzheimer's Disease (AD).

Cited by 7 publications

References 60 publications

Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy

Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy

Non-Ionic Surfactants for Stabilization of Polymeric Nanoparticles for Biomedical Uses

Amifostine-Loaded Nanocarrier Traverses the Blood–Brain Barrier and Prevents Radiation-Induced Brain Injury

Contact Info

Product

Resources

About