Polystyrene micro- and nano-particle coexposure injures fetal thalamus by inducing ROS-mediated cell apoptosis

Yang, Diqi; Zhu, Jiandi; Zhou, Xiaoshu; Pan, Di; Nan, Sha; Yin, Ruiling; Lei, Qianghui; Ma, Ning; Zhu, Hongmei; Chen, Jianguo; Li, Han; Ding, Mingxing; Ding, Yi

doi:10.1016/j.envint.2022.107362

Cited by 79 publications

(32 citation statements)

References 43 publications

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“…PS-MPs exposure can impair learning and memory by decreasing levels of acetylcholine, a neurotransmitter and inducing oxidative stress(Wang et al 2022). This was further con rmed with treatment of antioxidants such as GSH(Yang et al 2022) and Vitamin E (Wang et al 2022) to PS-MPs treated mice, which not only reversed the oxidative stress but also restored the learning ability and reversed the anxiety-like behaviour. In an independent-unpublished study we have also thrown light on PS-NPs induced oxidative stress, which alters learning and anxiety-like behaviour in mice (This manuscript is in process for publication).In all our results showed that PS-MPs can induce neurobehavioral implications in terms of anxiety and cognitive decline.…”

mentioning

confidence: 89%

Manifestation of polystyrene microplastic accumulation in tissues of vital organs including brain with histological and behaviour analysis on Swiss albino mice

Kaur

Sharma

John

et al. 2023

Preprint

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Plastic waste is persistent environmental pollutant, produced every year and cause unwanted ecological side effects. Microplastic (MPs) are small sized plastics found in cosmetics or those derived from degradation of larger plastic. MPs have shown harmful effects on both terrestrial and marine ecosystem. However, their effects on mammalian behaviour are scarcely studied. Recent reports indicated that toxic effects exhibited by MPs may vary with type, size, dosage, and duration of exposure. Specifically, how these MPs accumulate in vital organs including brain and affect behaviour of mice with different time period of exposure and dosage still needs to be investigated. Present study aimed to evaluate whether behavioural effects of polystyrene microplastic (PS-MPs) exposure varies with different time period and doses in adult male Swiss albino mice. Animals were orally exposed to 0.1mg/ml and 1mg/ml PS-MPs (of diameter 2 µm) for acute (15 days) and sub-chronic (30 and 60 days) time period. After the exposure period animals were subjected to behavioural test for accessing general locomotor behaviour (open field test), anxiety related behaviour (elevated plus maze) and learning behaviour (Morris water maze). Results showed that PS-MPs exposed animals exhibited behavioural changes like decreased exploration in open field, increased number of entries and time spent in closed arms of elevated plus maze as compared to control animals; giving indications of anxiety like effects due to PS-MPs. Treatment to PS-MPs also altered cognitive behaviour of mice, as treated mice spent more time in locating the hidden platform in Morris water maze. We demonstrated that exposure to PS-MPs can induce anxiety and impair learning just after 15 days of low dose exposure, however effects became more pronounced with increase in dose and time period of exposure. Further histological observation revealed that PS-MPs were found to be accumulated in gut, liver, kidney, and brain. To better understand pathology behind the behavioural and neurologic findings of the present study we further analysed histological structures of PS MPs exposed mice brain areas i.e., cortex, hippocampus, amygdala, and hypothalamus. PS MPs exposure caused decrease in hippocampal pyramidal cells and affected neuronal architecture of brain areas (cortex, hypothalamus, and amygdala), related with cognition and anxiety like-behaviour of mice. Our study provides novel insight into how accumulation and exposure at various time periods and dosage of microplastic particle cause histological and morphometric changes in different brain areas like i.e., cortex, hippocampus, amygdala, and hypothalamus which further lead to change in general and cognitive behaviour of mice.

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mentioning

confidence: 89%

Manifestation of polystyrene microplastic accumulation in tissues of vital organs including brain with histological and behaviour analysis on Swiss albino mice

Kaur

Sharma

John

et al. 2023

Preprint

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“…[225][226][227] The study by Liu et al 228 showed that silica NPs (SNPs) induced blood-brain barrier dysfunction in vitro and in vivo and produced massive ROS accumulation causing oxidative stress. Yang et al 229 showed that coexposure to PS-NPs damaged the fetal thalamus by inducing ROS-mediated apoptosis. It has also been shown that ZnO-NPs 230 and CuO-NPs 231 can cause hepatotoxicity and induce ROS accumulation and oxidative stress.…”

Section: Studies Between Nps and Rosmentioning

confidence: 99%

“…showed that silica NPs (SNPs) induced blood–brain barrier dysfunction in vitro and in vivo and produced massive ROS accumulation causing oxidative stress. Yang et al 229 . showed that coexposure to PS–NPs damaged the fetal thalamus by inducing ROS‐mediated apoptosis.…”

Section: Toxicological Mechanisms Of Npsmentioning

confidence: 99%

Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

Xuan

Zhao

Skonieczna

et al. 2023

MedComm

123

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Nanoparticles (NPs) have become one of the most popular objects of scientific study during the past decades. However, despite wealth of study reports, still there is a gap, particularly in health toxicology studies, underlying mechanisms, and related evaluation models to deeply understanding the NPs risk effects. In this review, we first present a comprehensive landscape of the applications of NPs on health, especially addressing the role of NPs in medical diagnosis, therapy. Then, the toxicity of NPs on health systems is introduced. We describe in detail the effects of NPs on various systems, including respiratory, nervous, endocrine, immune, and reproductive systems, and the carcinogenicity of NPs. Furthermore, we unravels the underlying mechanisms of NPs including ROS accumulation, mitochondrial damage, inflammatory reaction, apoptosis, DNA damage, cell cycle, and epigenetic regulation. In addition, the classical study models such as cell lines and mice and the emerging models such as 3D organoids used for evaluating the toxicity or scientific study are both introduced. Overall, this review presents a critical summary and evaluation of the state of understanding of NPs, giving readers more better understanding of the NPs toxicology to remedy key gaps in knowledge and techniques.

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“…Yang et al did a test with mice to observe the transportation of microplastics into biosystem. They injected orally polystyrene micro-and/or nano-particles with and without surface modifications into a mice during gestational days 1 to 17 and found the plastic particles in the alimentary tract, brain, uterus, and placenta in maternal mice (Yang et al, 2022). Ragusa et al also studied six human placentas collected from pregnant women and found 12 microplastic fragments (ranging from 5 to 10 μm in size) in 4 placentas (Ragusa et al, 2021).…”

Section: Micro and Nanoplastic Particles As Hydrophobic Contaminantsmentioning

confidence: 99%

“…Therefore, plastic is available in tap water, table salt, and mother's milk (Mendonca et al, 2014). Researchers have confirmed the presence of plastic particles in newborn babies and placentas (Ragusa et al, 2022;Yang et al, 2022). These microplastic particles include not only plastics but also many toxic chemicals (Wang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Biogenic polymer nanoparticles to remove hydrophobic organic contaminants from water

Kathalingam,

Santhoshkumar,

Ramesh

et al. 2023

Water Environment Research

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Soil and water pollution is of significant concern worldwide because of the consequences of environmental degradation and harmful effects on human health. Water bodies are very much polluted from various organic and inorganic pollutants by different human activities, including industrial wastes. Environmental pollution remains high because of urbanization‐induced industrial developments and human lifestyle. It accumulates pollutants in the environment including plants and living organisms. Even mothers’ milk is poisoned because of the uncontrolled, widespread increase in pollution. The discharge levels of organic hydrophobic contaminants in the water and soil are increasing rapidly. This severe pollution must be remediated to upgrade the environment and ensure the safety of human beings. It is vital to eradicate soil and water pollution to guarantee sufficient food and water. Different techniques available to remove the pollutants vary according to the type of pollutants. Hydrophobic contaminants are more dangerous than heavy metals and other pollutants; they cannot be easily removed, requiring special care. Hydrophobic organoxenobiotics released in the environment pose severe contamination in soil and water. Therefore, developing efficient and cost‐effective processes is necessary to remove hydrophobic contaminants from soil and water. With nanoparticle‐mediated remediation techniques, the green‐synthesized nanoparticles exhibit improved performance. This review consolidates reports on the remediation techniques of hydrophobic contaminants, focusing on green‐synthesized remediation agents. The very limited works on green synthesis of polymeric nanoparticles, particularly polyurethane‐based materials for organic contaminants removal demands more attention on this area.

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Polystyrene micro- and nano-particle coexposure injures fetal thalamus by inducing ROS-mediated cell apoptosis

Cited by 79 publications

References 43 publications

Manifestation of polystyrene microplastic accumulation in tissues of vital organs including brain with histological and behaviour analysis on Swiss albino mice

Manifestation of polystyrene microplastic accumulation in tissues of vital organs including brain with histological and behaviour analysis on Swiss albino mice

Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

Biogenic polymer nanoparticles to remove hydrophobic organic contaminants from water

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