Polystyrene microplastics enhance the microcystin-LR-induced gonadal damage and reproductive endocrine disruption in zebrafish

Wang, Lin; Luo, Huimin; Wu, Jingyi; Liu, Xiangli; Cao, Bangwei; Liu, Yuqing; Yang, Pinhong; Yang, Jun

doi:10.1016/j.scitotenv.2023.162664

Cited by 40 publications

(5 citation statements)

References 48 publications

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“…Another study conducted on zebrafish highlighted the impact of polystyrene microplastics, emphasizing their role in increasing the bioaccumulation of microcystin-LR and causing endocrinological disorders through gonadal damage. (Lin, Luo et al 2023). In a separate endocrinological study involving male Oryzias melastigma fish, the presence of polystyrene microplastics resulted in a significant estrogenic effect (Wang, Li et al 2022).…”

Section: Effects Of Microplastics On Fish Reproductive Systemmentioning

confidence: 98%

The Positive Effects of In Vivo/In Vitro Suplementation of Nanoparticles on Semen

Koca

2023

Nanotechnology in Reproduction

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Nanoparticles (NPs) are small size molecules. It is divided into organic and inorganic. Organic NPs have many clinical uses, from inoculation to homeostasis, long-term storage and delivery to the system, and absorption of topically used drugs into the skin. Inorganic NPs can be used in intraoperative lymphatic scanning, tumors, and anemia treatments. NPs have a favorable effect on sperm motility, kinematic parameters or membrane integrity rates, they can also be used as antibacterial, antiviral and antifungal in genital organ diseases. There are many studies in which the addition of NPs can be beneficial or harmful to sperm. Researchers have stated that it may be beneficial or cytotoxic depending on in vivo (such as airway, skin or injection) or in vitro use. It has been reported that NPs have positive effects on motility, kinematic parameters, plasma membrane integrity, DNA damage and acrosomal integrity and can be used as an antioxidant. In addition, it has been reported that it can be used in sexsorting, bioimaging and nanopurification, and that more studies on NPs will increase in the coming years.

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Section: Effects Of Microplastics On Fish Reproductive Systemmentioning

confidence: 98%

The Positive Effects of In Vivo/In Vitro Suplementation of Nanoparticles on Semen

Koca

2023

Nanotechnology in Reproduction

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“…Through the SIRT1/p53 pathway, PS-MPs adversely affect fertility, gonadal morphology, steroidogenesis, and the HPG axis. The HPG axis, an important endocrine regulatory pathway for fish reproduction, controls the production of sex hormones such as E 2 and T [ 129 ]. MNP exposure negatively influences the HPG axis in women, downregulating genes pertaining to the steroidogenic pathway and resulting in a reduction in E 2 and T levels in female plasma, leading to endocrine system disorders [ 99 ].…”

Section: Effects Of Mnps On the Reproductive System Of Zebrafishmentioning

confidence: 99%

Behavioral Studies of Zebrafish Reveal a New Perspective on the Reproductive Toxicity of Micro- and Nanoplastics

Wu,

Yu,

et al. 2024

Toxics

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The escalating prevalence of microplastics and nanoplastics in aquatic environments is a major challenge affecting the behavior and reproductive health of aquatic organisms while posing potential risks to human health and ecosystems. This review focuses on the neurobehavioral changes and reproductive toxicity of MNPs in zebrafish and their relationships. At the same time, the neurobehavioral changes caused by MNPs were studied, and the synergistic effects of the interaction of these pollutants with other environmental contaminants were explored. In addition, zebrafish, as a model organism, provide valuable insights into the subtle but important effects of MNPs on reproductive behavior, which is critical for understanding reproductive success, suggesting that behavioral changes can serve as an early biomarker of reproductive toxicity. In addition, based on classical endocrine disruptor models and behavioral research methods, the current status of the research on the reproductive toxicity of MNPs in zebrafish was reviewed, which further indicated that the behavioral parameters of zebrafish can be used as an effective and rapid tool to evaluate the reproductive toxicity of MNPs. However, behavioral methods for rapidly assessing the toxicity of MNPs are still an area of exploration. To address limitations and challenges in the current scope of research, this review outlines future research directions with the aim of improving our understanding of the environmental and health impacts of MNPs. This work aims to inform targeted environmental policies and advance public health strategies to address the growing challenge of MNPs pollution.

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“…The effect of polystyrene microplastics (PSMPs) on the bioavailability and reproductive disruptions caused by microcystin-LR (MC-LR) in zebrafish was investigated by Lin et al [ 152 ]. PSMPs enhanced the build-up of MC-LR in zebrafish gonads and intensified the reproductive damage caused by MC-LR.…”

Section: Health Impacts Of Microplasticsmentioning

confidence: 99%

From oceans to dinner plates: The impact of microplastics on human health

Emenike,

Okorie,

Ojeyemi

et al. 2023

Heliyon

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Polystyrene microplastics enhance the microcystin-LR-induced gonadal damage and reproductive endocrine disruption in zebrafish

Cited by 40 publications

References 48 publications

The Positive Effects of In Vivo/In Vitro Suplementation of Nanoparticles on Semen

The Positive Effects of In Vivo/In Vitro Suplementation of Nanoparticles on Semen

Behavioral Studies of Zebrafish Reveal a New Perspective on the Reproductive Toxicity of Micro- and Nanoplastics

From oceans to dinner plates: The impact of microplastics on human health

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