Polystyrene microplastics induced male reproductive toxicity in mice

Jin, Huixia; Ma, Tan; Sha, Xiaoxuan; Liu, Zhenyu; Zhou, Yuan; Meng, Xiannan; Chen, Yabing; Han, Xiaodong; Ding, Jie

doi:10.1016/j.jhazmat.2020.123430

Cited by 396 publications

(223 citation statements)

References 43 publications

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“…In one study 7 , for instance, mice fed large quantities of microplastics showed inflammation in their small intestines. Mice exposed to microplastics in two studies had a lowered sperm count 8 and fewer, smaller pups 9 , compared with control groups. Some of the in vitro studies on human cells or tissues also suggest toxicity.…”

Section: Human Studiesmentioning

confidence: 98%

Microplastics are everywhere — but are they harmful?

Lim¹

2021

Nature

439

169

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Section: Human Studiesmentioning

confidence: 98%

Microplastics are everywhere — but are they harmful?

Lim¹

2021

Nature

439

169

View full text Add to dashboard Cite

show abstract

“…MPs, which have small size and difficulty in biodegradation, can be easily ingested by organisms and after entering into the human body, some MPs can pass through the digestive epithelium and enter other tissues and cells via the circulatory system 7‐9 . Latest research found that after exposure for 24 h, MPs could disrupt blood‐testis barrier and accumulate in the testis of mice and induced testicular inflammation 10 . Hence, it is urgent to explore and address the MPs on the detrimental health effect.…”

Section: Introductionmentioning

confidence: 99%

The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3/Caspase‐1 signaling pathway and oxidative stress in Wistar rats

Wei

Wang

Liu

et al. 2021

Environmental Toxicology

109

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The extensive existing of microplastics (MPs) in the ecosystem have increased considerable attention concerning their potential adverse effects, the toxicities and the underlying mechanism of MPs are still scarce. To explore the effect of MPs on cardiac tissue in Wistar rats and unravel the mechanism of pyroptosis and oxidative stress in the process of cardiomyocytes injury, 32 male Wister rats were divided into control group and three model groups, which were exposed to 0.5 mm PS MPs at 0.5, 5 and 50 mg/L for 90 days. Results revealed that MPs could damage cardiac structure and function with impaired mitochondria integrity, as well as increased levels of creatine kinase‐MB and cardiac troponinI (cTnI). Moreover, MPs administration triggered oxidative stress as indicated by increased levels of malondialdehyde and decreased activity of superoxide dismutase, glutathione peroxidase and catalase. Treatment with MPs resulted in apoptosis and pyroptosis as evidenced by increasing expressions of interleukin (IL)‐1β, IL‐18. Additionally, MPs were shown to induce the NOD‐like receptor protein 3 inflammasomes activation in cardiac tissue, enabling activation of Caspase‐1‐dependent signaling pathway induced by inflammatory stimuli resulting from oxidative stress. In summary, these results illustrated that pyroptosis played a vital role in polystyrene MPs‐induced cardiotoxicity, which might be helpful to understand the mechanism of cardiac dysfunction and induced by MPs.

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“…(2019) and Rafiee et al (2018) in which translocation of PS particles from the gut was not observed and toxicologically relevant effects related to PS exposure were not found in vivo in rodents or in vitro in human intestinal epithelium 32 , 33 . Even more recently, however, several studies have suggested that microplastics can induce gut microbiota dysbiosis, intestinal barrier dysfunction, inflammation, and metabolic disorders in both mice and their offspring 34 – 46 .…”

Section: Introductionmentioning

confidence: 99%

Harnessing PET to track micro- and nanoplastics in vivo

Keinänen

Dayts

Rodriguez

et al. 2021

Sci Rep

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The proliferation of plastics in the environment continues at an alarming rate. Plastic particles have been found to be persistent and ubiquitous pollutants in a variety of environments, including sea water, fresh water, soil, and air. In light of this phenomenon, the scientific and medical communities have become increasingly wary of the dangers posed to human health by chronic exposure to microplastics (< 5 mm diameter) and nanoplastics (< 100 nm diameter). A critical component of the study of the health effects of these pollutants is the accurate determination of their pharmacokinetic behavior in vivo. Herein, we report the first use of molecular imaging to track polystyrene (PS) micro- and nanoplastic particles in mammals. To this end, we have modified PS particles of several sizes—diameters of 20 nm, 220 nm, 1 µm, and 6 µm—with the chelator desferrioxamine (DFO) and radiolabeled these DFO-bearing particles with the positron-emitting radiometal zirconium-89 (89Zr; t1/2 ~ 3.3 d). Subsequently, positron emission tomography (PET) was used to visualize the biodistribution of these radioplastics in C57BL/6J mice at 6, 12, 24, and 48 h after ingestion. The imaging data reveal that the majority of the radioplastics remain in the gastrointestinal tract and are eliminated through the feces by 48 h post-ingestion, a result reinforced by acute biodistribution studies. Ultimately, this work suggests that nuclear imaging—and PET in particular—can be a sensitive and effective tool in the urgent and rapidly growing effort to study the in vivo behavior and potential toxicity of micro- and nanoplastics.

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Polystyrene microplastics induced male reproductive toxicity in mice

Cited by 396 publications

References 43 publications

Microplastics are everywhere — but are they harmful?

Microplastics are everywhere — but are they harmful?

The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3/Caspase‐1 signaling pathway and oxidative stress in Wistar rats

Harnessing PET to track micro- and nanoplastics in vivo

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