Polystyrene microplastics modulated bdnf expression triggering neurotoxicity via apoptotic pathway in zebrafish embryos

Suman, Anjali; Mahapatra, Archisman; Gupta, Prem K.; Ray, Shubhendu Shekhar; Singh, Rahul Kumar

doi:10.1016/j.cbpc.2023.109699

Cited by 8 publications

(1 citation statement)

References 58 publications

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“…Moreover, its genome is very well characterized and it shares a high degree of homology with the human genome [72]. Several studies performed on zebrafish embryos showed that PS MNPs (see Table 1) can alter the expression of genes involved in the stress response and cellular detoxification, apoptotic genes, immune response, and genes involved in neurotransmission, leading to developmental delay, hatching problems, and impaired swimming behaviour [35,[49][50][51]. The same model organism was used to analyze the full transcriptome of embryos exposed to PS NPs (50-200 nm, 100-1000 ppb).…”

Section: Effects Of Ps Mnps On the Transcriptome Of Fishesmentioning

confidence: 99%

Polystyrene Micro- and Nanoplastics (PS MNPs): A Review of Recent Advances in the Use of -Omics in PS MNP Toxicity Studies on Aquatic Organisms

Eliso,

Billè,

Cappello

et al. 2024

Fishes

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In recent years, micro- and nanoplastics (MNPs) have represented an emerging threat for the aquatic environment due to their persistence and widespread distribution. Indeed, their small size and increased surface area lead to a high biological reactivity, which can be crucial for the health status of biota. To date, several studies have investigated lethal and sublethal endpoints of MNPs, while one of the main challenges is to understand their mechanisms of toxicity in a comprehensive manner. With this aim, the field of aquatic ecotoxicology can now benefit from the -omics approaches. This review focuses on the recent advances related to the use of transcriptomics, proteomics, and metabolomics to deeply investigate the molecular and biochemical responses of aquatic organisms, both fishes and aquatic invertebrates, to pristine polystyrene (PS) MNPs. The literature reviewed revealed that transcriptomics and metabolomics are the most frequently used -omic approaches. Overall, the studies taken into consideration shed light on the events triggered by PS MNPs at molecular and cellular levels, identifying as mechanisms of toxicity the pathways involved in oxidative stress, energy metabolism, immune response, and the nervous system. Future studies should therefore focus on the use and integration of multi-omics approaches for a more comprehensive understanding of the mechanisms involved in MNPs toxicity.

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Section: Effects Of Ps Mnps On the Transcriptome Of Fishesmentioning

confidence: 99%

Polystyrene Micro- and Nanoplastics (PS MNPs): A Review of Recent Advances in the Use of -Omics in PS MNP Toxicity Studies on Aquatic Organisms

Eliso,

Billè,

Cappello

et al. 2024

Fishes

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Zebrafish and Drosophila as Model Systems for Studying the Impact of Microplastics and Nanoplastics ‐ A Systematic Review

Sankar,

Chandrasekaran,

Meivelu Moovendhan

et al. 2024

Environmental Quality Mgmt

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Microplastics and nanoplastics (MNPs) are byproducts of plastics created to benefit humanity, but improper disposal and inadequate recycling have turned them into a global menace that we can no longer conceal. As they interact with all living organisms, including humans, their mechanism of interaction and their perilous impact must be meticulously investigated. To uncover the secrets of MNPs, there must be model systems that exist to interlink the two major scenarios: they must represent the environmental impact and be relevant to humans. Therefore, zebrafish and Drosophila are perfect to describe these two cases, as they are well studied and relatable to humans. In this review, 39% zebrafish studies reported higher mortality and hatching rates at greater MNP concentrations, severe oxidative stress as seen by raised malondialdehyde (MDA) levels, and reduced superoxide dismutase (SOD) activity. About 50% of studies showed severe neurotoxic behavior with drop of locomotor activity, suggesting neurotoxicity. MNPs have a significant impact on fertility rate of Drosophila. More than half of the studies revealed genotoxicity in Drosophila as observed by wing spot assays and modified genomic expressions associated with stress and detoxification processes. These findings emphasize the potential of MNPs to bioaccumulate, impair physiological systems, and cause oxidative and neurobehavioral damage. This study underscores the importance for thorough risk evaluations of MNPs and their environmental and health consequences.

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Advances of microplastics ingestion on the morphological and behavioral conditions of model zebrafish: A review

Rojoni,

Ahmed,

Rahman

et al. 2024

Aquatic Toxicology

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Polystyrene microplastics modulated bdnf expression triggering neurotoxicity via apoptotic pathway in zebrafish embryos

Cited by 8 publications

References 58 publications

Polystyrene Micro- and Nanoplastics (PS MNPs): A Review of Recent Advances in the Use of -Omics in PS MNP Toxicity Studies on Aquatic Organisms

Polystyrene Micro- and Nanoplastics (PS MNPs): A Review of Recent Advances in the Use of -Omics in PS MNP Toxicity Studies on Aquatic Organisms

Zebrafish and Drosophila as Model Systems for Studying the Impact of Microplastics and Nanoplastics ‐ A Systematic Review

Advances of microplastics ingestion on the morphological and behavioral conditions of model zebrafish: A review

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