Polystyrene microspheres as bioligand carriers in the determination of Δ-9-tetrahydrocannabinol in human urine

Solodukhina, N. М.; Zlydneva, Liubov A.; Levshenko, E. N.; Myagkova, M. A.

doi:10.1134/s0003683812090062

Cited by 6 publications

(2 citation statements)

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“…Используя функциональные (содержащие амино-и карбоксильные группы) кремнийорганические ПАВ различного строения, а также варьируя их концентрацию в рецептурах синтеза были синтезированы полимерные суспензии с разной природой функциональных групп на поверхности полимерных микросфер. [12][13]. Оказалось возможным получить полимерные суспензии с диаметрами 0,3-1,0 мкм с узким распределением по размерам одностадийным способом в экологически чистых условиях (отсутствие ПАВ в водной фазе) при концентрациях, много меньших обычно используемых в присутствии водорастворимых ПАВ (1,0 и 5,0 масс.% в расчете на мономер, соответственно).…”

Section: Introductionunclassified

SYNTHESIS AND PROPERTIES OF POLYMER SUSPENSIONS OBTAINED BY HETEROPHASE POLYMERIZATION IN THE PRESENCE OF Α,ω BIS[3 GLYCIDOXYPROPYL]POLYDIMETHYLSILOXANE

2023

Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol.

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Polymeric microspheres with glycidoxy groups on the surface can be used as bioligand carriers in diagnostic test systems. However, the possibility of synthesizing aggregatively stable functional polymeric microspheres in a wide range of diameters is an urgent problem of modern polymer chemistry. This article is devoted to a systematic study of the kinetics of styrene and methyl methacrylate polymerization in the presence of an organosiloxane surfactant with terminal glycidoxy groups – α,ω-bis[3-glycidoxyproopyl]-polydimethylsiloxane, PDMS(CHOCH2). The article shows the influence of phases volume ratio, initiator and surfactant concentration, synthesis temperature and pH of initial medium on the properties of polymer suspensions (their aggregative stability, monodispersity, particle diameter). The formation of polymer-monomer particles during polymerization has been studied and it has been shown that polymer suspensions retain high aggregation stability from early period of monomer conversion, and the particle diameter changes untill 30% of the monomer conversion. Due to the high surface activity of the organosiloxane surfactant used and its incompatibility with the resulting polymer, aggregatively stable functional polymer suspensions with diameters from 0.09 to 1.1 μm were obtained by a single-stage synthesis. Studies of the hydration degree of polymer microspheres have shown that the presence of functional glycidoxy groups on their surface ensures the formation of a hydration shell, which increases the stability of polymer particles, and also makes it possible to use the resulting microspheres as carriers of bioligands. Thus, the use of water-insoluble organosiloxane surfactants as stabilizers for the heterophase polymerization of vinyl monomers makes it possible to synthesize aggregatively stable functional polymer suspensions in a wide range of diameters. The use of organosiloxane surfactants with various functional groups expands the range of functional polymer microspheres used in various fields of application.

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Section: Introductionunclassified

SYNTHESIS AND PROPERTIES OF POLYMER SUSPENSIONS OBTAINED BY HETEROPHASE POLYMERIZATION IN THE PRESENCE OF Α,ω BIS[3 GLYCIDOXYPROPYL]POLYDIMETHYLSILOXANE

2023

Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol.

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“…In this paper, a new strategy was presented to overcome the heterogeneity of the matrix–analyte crystals. Polystyrene (PS) colloidal spheres, characterized by their large specific surface area, agglutination, and uniform spherical morphology, have shown considerable potential application in optical devices, catalysis, and being used as a template in recent years. − More importantly, PS colloidal spheres have a superior monodispersed property and can self-assemble to form photonic crystals, and according to particular demand, some other substances such as organic dye or polymer monomer could be mixed into the colloidal spheres. , It inspired a new thought: when mixing matrix and analytes with PS colloidal spheres, along with PS colloidal spheres self-assembling, PS spheres may act as a crystal nucleus, which could combine with matrix-analytes, and finally result in a homogeneous crystal like photonic crystal. On the basis of this hypothesis, in this study, we examined the morphology of the crystal and the feasibility of using PS spheres-assisted MALDI MS for quantitative analysis.…”

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Polystyrene Spheres-Assisted Matrix-Assisted Laser Desorption Ionization Mass Spectrometry for Quantitative Analysis of Plasma Lysophosphatidylcholines

Wei

Li²,

Wang³

et al. 2013

Anal. Chem.

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The quantitative analysis by matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) is a challenge due to the poor reproducibility originating from the heterogeneity of the matrix-analyte crystals. Polystyrene (PS) colloidal spheres have superior monodispersed property and can self-assemble to form photonic crystals. With the assistance of PS spheres, a uniform matrix-analyte cocrystal was constructed for the quantitative analysis of plasma lysophosphatidylcholines (LPCs). The matrix and the solvent in MALDI MS analysis were optimized, and the reproducibility and the accuracy were investigated in detail. This is the first report about the very simple method of PS spheres-assisted MALDI MS for quantitative analysis, where it is believed that this approach will greatly expand the applications of MALDI MS.

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Behavior of Organosilicon Surfactants in Langmuir Films on the Surface of Water

et al. 2019

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Polystyrene microspheres as bioligand carriers in the determination of Δ-9-tetrahydrocannabinol in human urine

Cited by 6 publications

References 0 publications

SYNTHESIS AND PROPERTIES OF POLYMER SUSPENSIONS OBTAINED BY HETEROPHASE POLYMERIZATION IN THE PRESENCE OF Α,ω BIS[3 GLYCIDOXYPROPYL]POLYDIMETHYLSILOXANE

SYNTHESIS AND PROPERTIES OF POLYMER SUSPENSIONS OBTAINED BY HETEROPHASE POLYMERIZATION IN THE PRESENCE OF Α,ω BIS[3 GLYCIDOXYPROPYL]POLYDIMETHYLSILOXANE

Polystyrene Spheres-Assisted Matrix-Assisted Laser Desorption Ionization Mass Spectrometry for Quantitative Analysis of Plasma Lysophosphatidylcholines

Behavior of Organosilicon Surfactants in Langmuir Films on the Surface of Water

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