Polystyrene nanoplastics dysregulate lipid metabolism in murine macrophages in vitro

Florance, Ida; Seenivasan, R.; Mukherjee, Amitava; Chandrasekaran, Natarajan

doi:10.1016/j.tox.2021.152850

Cited by 66 publications

(45 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data show enhanced inflammatory cytokine and adhesion molecule expression in vitro and in vivo . These findings are in line with other in vitro studies observing enhanced intestinal gene transcription of classical inflammatory pathways like nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) [ 17 ] or production of reactive oxygen species and elevated lipotoxicity in macrophages [ 12 ] after stimulation with polystyrene. Furthermore, in vivo we observed an increase in hepatic mRNA expression of the acute-phase proteins Saa1 , Saa2 and Saa3 after polystyrene microplastic administration, representing a well-known reaction of the liver to inflammatory stimuli [ 16 ].…”

Section: Discussionsupporting

confidence: 90%

“…Recent studies reported microplastic particle accumulation in different organs like liver and heart upon oral administration [ 8 – 10 ], demonstrating their uptake via the intestine into the circulation where they may interact with immune cells and the endothelium promoting inflammatory effects [ 11 ]. Additionally, PS particles have been shown to impair lipid metabolism in murine macrophages [ 12 ] and to trigger hepatoxicity [ 13 ]. In the context of a potential use of PS particles as drug carriers, Barshtein et al observed elevated aggregation and endothelial adhesion of red blood cells treated with PS in vitro [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Polystyrene microplastic particles induce endothelial activation

et al. 2021

View full text Add to dashboard Cite

Due to its increasing production, durability and multiple applications, plastic is a material we encounter every day. Small plastic particles from the μm to the mm range are classified as microplastics and produced for cosmetic and medical products, but are also a result of natural erosion and decomposition of macroplastics. Although being omnipresent in our environment and already detected in various organisms, less is known about the effects of microplastics on humans in general, or on vascular biology in particular. Here we investigated the effects of carboxylated polystyrene microplastic particles (PS, 1 μm) on murine endothelial and immune cells, which are both crucially involved in vascular inflammation, using in vitro and in vivo approaches. In vitro, PS induced adhesion molecule expression in endothelial cells with subsequent adhesion of leukocytes both under static and flow conditions. In monocytic cells, PS enhanced pro-inflammatory cytokine expression and release. Accordingly, administering mice with PS led to enhanced aortic expression of cytokines and adhesion molecules. Furthermore, we identified neutrophils as the PS-clearing blood leukocyte population. The findings from this study for the first time indicate polystyrene microplastic as a new environmental risk factor for endothelial inflammation.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Polystyrene microplastic particles induce endothelial activation

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Notably, the nanomaterials could affect the lipid metabolism and functions of cells ( Kim S. J. et al, 2021 ; Florance et al, 2021 ). Therefore, the biological effects of nanoparticles should be further studied, and this part will not be discussed in the review.…”

Section: Nanotechnology-based Lipid Metabolism Regulation For the Enh...mentioning

confidence: 99%

Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity

Gao

Sun

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

The hallmarks of cancer include dysregulated metabolism and immune evasion. As a basic way of metabolism, lipid metabolism is reprogrammed for the rapid energy and nutrient supply in the occurrence and development of tumors. Lipid metabolism alterations that occur in the tumor microenvironment (TME) affect the antitumor responses of immune cells and cause immune evasion. Therefore, targeting lipid metabolism in the TME for enhancing the antitumor effect of immune cells is a promising direction for cancer treatment. Cancer nanomedicine has great potential in regulating tumor metabolism and tumor immunity. This review summarizes the nanotechnology-based strategies for lipid metabolism regulation in the TME for enhanced anticancer immune responses.

show abstract

“…Based on scientific evidence, the serious risks of PS MNPs have been fully justified as a cause of cellular toxicity in mammals [ 37 ]. Many researchers have studied the chemical and physical toxicities of micro-sized (or nano-sized) PS fragments by in vitro experiments using [ 13 ], for example, human lung cells [ 38 ], human HepG2 cells [ 39 ], human-derived cells [ 40 ], RAW 264.7 macrophages [ 41 ], human gastric adenocarcinoma cells [ 42 ], and L02 cells [ 43 ]. Furthermore, in vivo experiments were conducted using mice [ 26 , 44 ], Daphnia magna [ 45 ], zebra fish [ 17 ], red tilapia [ 25 ], and fathead minnow [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

Advanced microplastic monitoring using Raman spectroscopy with a combination of nanostructure-based substrates

Kim

Lee

et al. 2022

J Nanostruct Chem

View full text Add to dashboard Cite

Micro(nano)plastic (MNP) pollutants have not only impacted human health directly, but are also associated with numerous chemical contaminants that increase toxicity in the natural environment. Most recent research about increasing plastic pollutants in natural environments have focused on the toxic effects of MNPs in water, the atmosphere, and soil. The methodologies of MNP identification have been extensively developed for actual applications, but they still require further study, including on-site detection. This review article provides a comprehensive update on the facile detection of MNPs by Raman spectroscopy, which aims at early diagnosis of potential risks and human health impacts. In particular, Raman imaging and nanostructure-enhanced Raman scattering have emerged as effective analytical technologies for identifying MNPs in an environment. Here, the authors give an update on the latest advances in plasmonic nanostructured materials-assisted SERS substrates utilized for the detection of MNP particles present in environmental samples. Moreover, this work describes different plasmonic materials—including pure noble metal nanostructured materials and hybrid nanomaterials—that have been used to fabricate and develop SERS platforms to obtain the identifying MNP particles at low concentrations. Plasmonic nanostructure-enhanced materials consisting of pure noble metals and hybrid nanomaterials can significantly enhance the surface-enhanced Raman scattering (SERS) spectra signals of pollutant analytes due to their localized hot spots. This concise topical review also provides updates on recent developments and trends in MNP detection by means of SERS using a variety of unique materials, along with three-dimensional (3D) SERS substrates, nanopipettes, and microfluidic chips. A novel material-assisted spectral Raman technique and its effective application are also introduced for selective monitoring and trace detection of MNPs in indoor and outdoor environments. Graphical abstract

show abstract

Polystyrene nanoplastics dysregulate lipid metabolism in murine macrophages in vitro

Cited by 66 publications

References 61 publications

Polystyrene microplastic particles induce endothelial activation

Polystyrene microplastic particles induce endothelial activation

Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity

Advanced microplastic monitoring using Raman spectroscopy with a combination of nanostructure-based substrates

Contact Info

Product

Resources

About