Polystyrene nanoplastics synergistically exacerbate diclofenac toxicity in embryonic development and the health of adult zebrafish

Kandaswamy, Karthikeyan; Guru, Ajay; Panda, Siva Prasad; Antonyraj, Anahas Perianaika Matharasi; Kari, Zulhisyam Abdul; Giri, Jayant; Almutairi, Bader O.; Arokiyaraj, Selvaraj; Malafaia, Guilherme; Arockiaraj, Jesu

doi:10.1016/j.cbpc.2024.109926

Comparative Biochemistry and Physiology Part C: Toxicology &amp

2024

DOI: 10.1016/j.cbpc.2024.109926

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Polystyrene nanoplastics synergistically exacerbate diclofenac toxicity in embryonic development and the health of adult zebrafish

Karthikeyan Kandaswamy,

Ajay Guru,

Siva Prasad Panda

et al.

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Cited by 4 publications

References 83 publications

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Neurobehavioral and bioaccumulative toxicity in adult in‐vivo zebrafish model due to prolonged cadmium exposure in the presence of ketoprofen

Madesh,

Sudhakaran,

Meenatchi

et al. 2024

J Biochem & Molecular Tox

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Increasing industrial activity causes the release of chemical compounds into aquatic habitats, including toxic heavy metals like cadmium and medications like ketoprofen, posing considerable ecological concerns. Although previous studies have shown that cadmium and ketoprofen individually cause cognitive impairment, there is a lack of information on the combined neurological effects of the two substances. We investigated the neurological consequences of persistent cadmium exposure in the presence of ketoprofen on adult zebrafish, providing an essential model for understanding cumulative impacts on vertebrate organisms. Behavioral assessments, bioaccumulation rates, biochemical studies, and histopathological exams were conducted over 42 days in authentic environmental settings. The results of our study show that cadmium (10 µg/L) and ketoprofen (10 and 100 µg/L) at environmentally relevant concentrations had a significant impact on locomotor activity, social interactions, and cognitive responses, indicating cumulative neurotoxicity in co‐exposure groups compared to single pollutant groups. Biochemical tests show disturbances in antioxidant defense systems, while histological examinations reveal structural changes in zebrafish brain regions. Ketoprofen influences cadmium accumulation in the brain, underscoring the importance of conducting complete evaluations to understand the intricate interactions between environmental pollutants. This study improves our understanding of the complex interactions between heavy metals and medications, stressing the need to consider combined exposure when assessing the neurological effects on vertebrate models.

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Neurobehavioral and bioaccumulative toxicity in adult in‐vivo zebrafish model due to prolonged cadmium exposure in the presence of ketoprofen

Madesh,

Sudhakaran,

Meenatchi

et al. 2024

J Biochem & Molecular Tox

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Ferroptosis involvement in the neurotoxicity of flunitrazepam in zebrafish

Qin,

Lin,

Ren

2024

Aquatic Toxicology

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Bisphenol A-induced ovarian damage countered by luteolin: Experiments in in vitro CHO cells and in vivo PCOS phenotype zebrafish

Sudhakaran,

Kesavan,

Ranjan Nayak

et al. 2024

Tissue and Cell

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Polystyrene nanoplastics synergistically exacerbate diclofenac toxicity in embryonic development and the health of adult zebrafish

Cited by 4 publications

References 83 publications

Neurobehavioral and bioaccumulative toxicity in adult in‐vivo zebrafish model due to prolonged cadmium exposure in the presence of ketoprofen

Neurobehavioral and bioaccumulative toxicity in adult in‐vivo zebrafish model due to prolonged cadmium exposure in the presence of ketoprofen

Ferroptosis involvement in the neurotoxicity of flunitrazepam in zebrafish

Bisphenol A-induced ovarian damage countered by luteolin: Experiments in in vitro CHO cells and in vivo PCOS phenotype zebrafish

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