Decisions regarding the legal status of cannabis have long been framed (for the public at least) with reference to the perceived health risks and harms associated with use. Yet, drug policy and legislation relating to the use of cannabis are rarely based on the scientific evidence of the known risks and harms. There are many reasons for this discrepancy, with the politicization of cannabis use, where ideology and moralizing are given precedence over the science, being one. Thus, we begin this research topic with Aggarwal (1) discussion of how such politicization has contributed to the current smokescreen that is obscuring our understanding of cannabis, including the impact it has on the ability of researchers to collect and disseminate accurate information about the effects of cannabis use.The capacity of policy makers and legislators to develop evidence-based cannabis policies and laws is also contingent on researchers explaining the existing evidence, disseminating new research findings, and collaborating with relevant people, agencies, and government departments to improve the premises on which they base their policies and legislation. Roffman (2), who took this path through his involvement in the development of the legislation to legalize cannabis use in Washington State, provides an insider's view of the processes and deliberations. While we will have to wait for the evaluation of this carefully designed model for regulating cannabis use, the following two articles provide some insight into patterns of cannabis use in contexts were consumption is relatively normalized. There are many parallels evident in the findings of Mostaghim and Hathaway (3) qualitative exploration of cannabis use among Canadian university students and Liebregts et al. (4) prospective investigation of cannabis use by young adults transitioning from university to work in The Netherlands. Of particular note are the ways in which the participants' self-identity, including priorities, roles, and responsibilities, act as constraints to their use, and the clear demarcations drawn between leisure and work.A major consideration, discussed by Roffman (2), was the risk that legalization of cannabis might spark an increase in usage, which could, in turn, result in higher incidence and prevalence of cannabis-related harms, particularly if there was an increase in use by adolescents. The evidence underpinning concerns of adverse impacts resulting from early onset cannabis use is reviewed by Chadwick et al. (5), who report that adolescent users with genetic vulnerabilities are at increased risk of experiencing motivational, affective, and psychotic disorders, including schizophrenia. The association between cannabis and psychosis/schizophrenia is comprehensively reviewed by Radhakrishnan et al. (6), who conclude that, while, cannabis may be a component cause in the development of psychosis, this association is moderated by family history of psychoses, genetic factors, childhood trauma/abuse, and age at onset of use. The importance of differentiating...