Polysulfides and products of H 2 S/S-nitrosoglutathione in comparison to H 2 S, glutathione and antioxidant Trolox are potent scavengers of superoxide anion radical and produce hydroxyl radical by decomposition of H 2 O 2

Misak, Anton; Grman, Marian; Bačová, Zuzana; Režuchová, Ingeborg; Hudecová, Soňa; Ondriašová, Elena; Križanová, Oľga; Brezová, Vlasta; Chovanec, Miroslav; Ondriaš, Karol

doi:10.1016/j.niox.2017.09.006

Cited by 31 publications

(48 citation statements)

References 94 publications

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“…It is found in almost all types of cell compartments: cytosol, ER, mitochondria, and vacuoles at millimolar concentration (Jimenez, Hernandez, Pastori, Rio, & Sevilla, ; Meister & Anderson, ). GSH scavenges many ROS such as H 2 O 2,

O_{2}^{- \cdot}

and · OH (Misak et al, ). One of the basic role of GSH as an antioxidant is its ability to restore ascorbic acid via the ascorbate‐GSH cycle (Noctor & Foyer, ).…”

Section: Antioxidantsmentioning

confidence: 99%

Understanding oxidants and antioxidants: Classical team with new players

et al. 2020

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The free radical oxidants such as reactive oxygen species, reactive nitrogen species, and reactive sulfur species are produced inside cells through various metabolic processes. The body is equipped with an antioxidant defense system that guards against oxidative damage caused by these reactive oxidants and plays a major role in protecting cells from oxidative stress and damage. Antioxidants such as glutathione (GSH), thioredoxin, ascorbic acid and enzymes, for example, superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) counter the oxidative stress and protect lipids, proteins, and DNA. Antioxidants such as tocopherols, ascorbic acid, carotenoids, flavonoids, amino acids are also natural antioxidants present in foods. There is increasing demand and availability of designer foods fortified with antioxidants and probiotics that may be important in human health. The review article presents a brief overview of oxidants and antioxidant systems inside the human body including the role of probiotics and inflammation. Practical applications Antioxidants such as GSH, thioredoxin, ascorbic acid, etc. and protective enzymes, for example, SOD, GPx, CAT, etc. counter oxidative stress and protect cellular biomolecules. Antioxidants such as tocopherols, ascorbic acid, carotenoids, flavonoids, amino acids, phospholipids, and sterols are natural antioxidants found in consumed foods. They play a major role in scavenging free radical and non‐radical oxidants, and protect cells from oxidative stress and damage. The importance of antioxidants can be understood from the fact that oxidative damage is now associated with a variety of diseases including cancer, neurodegeneration, diabetes, etc. Several approaches to improve human health and achieve longevity use dietary antioxidants as formulation in diet and fortified foods. Antioxidants also maintain freshness and prolonging the shelf life of food products. The fortified or designer foods that are added with antioxidant nutrients and the use of microorganisms as probiotics are increasingly available in the market as health foods and supplements.

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O_{2}^{- \cdot}

and · OH (Misak et al, ). One of the basic role of GSH as an antioxidant is its ability to restore ascorbic acid via the ascorbate‐GSH cycle (Noctor & Foyer, ).…”

Section: Antioxidantsmentioning

confidence: 99%

Understanding oxidants and antioxidants: Classical team with new players

et al. 2020

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“…In addition, H 2 S may interact with other reactive species, e.g., oxygen, nitrogen, sulfur and selenium species. These species are produced by various cellular enzymes (NADPH oxidase, xanthine oxidase, uncoupled NOS) and their mutual interaction leads to the formation of numerous products, contributing mostly to the redox biology of the cell [77][78][79][80][81].…”

Section: H 2 S Signalingmentioning

confidence: 99%

Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors

et al. 2020

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Hydrogen sulfide (H2S) is one of the important biological mediators involved in physiological and pathological processes in mammals. Recently developed H2S donors show promising effects against several pathological processes in preclinical and early clinical studies. For example, H2S donors have been found to be effective in the prevention of gastrointestinal ulcers during anti-inflammatory treatment. Notably, there are well-established medicines used for the treatment of a variety of diseases, whose chemical structure contains sulfur moieties and may release H2S. Hence, the therapeutic effect of these drugs may be partly the result of the release of H2S occurring during drug metabolism and/or the effect of these drugs on the production of endogenous hydrogen sulfide. In this work, we review data regarding sulfur drugs commonly used in clinical practice that can support the hypothesis about H2S-dependent pharmacotherapeutic effects of these drugs.

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“…[35][36][37] H 2 S has mostly beneficial effects under conditions of oxidative stress by reacting with reactive oxygen and nitrogen species. [38][39][40][41][42] It has both pro-and anticancer effects depending on the cell type, concentration and interaction with other cellular molecules. [43][44][45] Glutathione (GSH) is another intracellular natural antioxidant, which has many biological roles including modulation of cellular redox homeostasis and protection against reactive oxygen and nitrogen species.…”

Section: Introductionmentioning

confidence: 99%

“…The activities of R-O and phthalic thioanhydride (R-S) were examined in parallel for comparison. Since H 2 S and GSH interact with several biologically active molecules, modulating their activities, 42,[46][47][48]53 the interactions of H 2 S and GSH with these three phthalic anhydride derivatives and their molecular consequences were also analysed, expecting that in these instances R-Se would be the most reactive one thanks to its higher expected reactivity. The reduction of the cPTIO and superoxide (O 2 À ) radicals, and plasmid DNA (pDNA) cleavage assay were employed to monitor these consequences.…”

Section: Introductionmentioning

confidence: 99%