Polysulfone membranes. V. Poly(phenyl sulfone) (Radel R)–poly(vinyl pyrrolidone) membranes

Dal‐Cin, Mauro M.; Tam, C.M.; Guiver, Michael D.; Tweddle, T. A.

doi:10.1002/app.1994.070540609

Cited by 39 publications

(27 citation statements)

References 11 publications

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“…Addition of ethyl heptanoate as a hydrophobic additive decreases the exchange rate of solvent and the nonsolvent in coagulation bath and, therefore, the sponge-like structure takes over the other structures. 5,26,27 In comparison to other formulations, the sponge-like morphology in systems containing ethyl heptanoate causes the lowest level of leuprolide acetate release. It is to be noted that there is a challenge between the surface and cross section morphologies by comparing the control system with that having additives in determining the rate of drug release.…”

Section: Morphological Studiesmentioning

confidence: 97%

Effect of additives on release profile of leuprolide acetate in an in situ forming controlled‐release system: In vitro study

Zare

Mobedi

Barzin

et al. 2007

J of Applied Polymer Sci

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In situ forming drug delivery system is prepared by phase inversion technique using poly (D,L-lacticco-glycolide) and leuprolide acetate dissolved in N-methyl-2-pyrrolidone. The effects of ethyl heptanoate and glycerol additives are important determinant as rate modifying agents on the drug release kinetics in biodegradable in situ forming porous systems of poly(D,L-lactide-co-glycolide) (PLGA) in N-methyl-2-pyrrolidone (NMP). The release performance and porous structure morphology are investigated by scanning electron microscopy and UV-visible spectroscopy techniques to study the effect of additives. The experimental results exhibit the crucial role of ethyl heptanoate and glycerol at different loadings (1, 3, and 5% w/w) on release profile of leuprolide acetate loaded on poly(D,L-lactide-co-glycolide)hydroxylated (PLGA-H). Both additives at different concentrations reduce the burst effect, while increasing duration of drug release. Ethyl heptanoate, however, shows stronger effect than glycerol. The results of morphological studies show that ethyl heptanoate reduces the porosity of the polymer surface and interconnected tear-like structures of the bulk disappear while the sponge-like structures are observed. In this system glycerol reduces the surface porosity intensively, while the interconnected tears change into channel-like structures. Therefore, morphological results confirm the effect of additives on leuprolide release profile.

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Section: Morphological Studiesmentioning

confidence: 97%

Effect of additives on release profile of leuprolide acetate in an in situ forming controlled‐release system: In vitro study

Zare

Mobedi

Barzin

et al. 2007

J of Applied Polymer Sci

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“…The membrane casting formulation contained 25% polysulfone (Radel-R Amoco, USA) and 21% polyvinylpyrrolidone (PVP) (Sigma, USA) in N-methyl-2-pyrrolidinone (NMP) (Anachemia, USA). The membrane was prepared by the phase inversion method and characterized as described elsewhere [13]. Dextran T40 (Polysciences Inc., USA) with a molecular weight of 39 kDa was used as the standard solute.…”

Section: Materials and Apparatusmentioning

confidence: 99%

Experimental studies in the dead-end ultrafiltration of dextran: analysis of concentration polarization

Zaidi

Kumar

2004

Separation and Purification Technology

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“…Membrane casting formulation contained 25% of polysulfone, (Radel-R Amoco, U.S.) and 21% polyvinylpyrrolidone (PVP) (Sigma, U.S.) in N-methyl-2-pyrrolidinone (NMP) (Anachemia, U.S.). The membrane was prepared by the phase inversion method, details of that are given elsewhere (Dal-Cin et al, 1994). Throughout this investigation, Polyethylene Glycol (PEG) (Fluka chemie AG, Switzerland) with 35 kDa molecular weight was used as a standard solute.…”

Section: Experimental Materialsmentioning

confidence: 99%

A New Method for Identifying Osmotically Limited and Gel Layer Controlled Pressure Independent Flux in Ultrafiltration

et al. 2004

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An unequivocal determination of whether pressure independent flux regime is osmotically controlled or gel layer dominated, is still open for discussion in the membrane literature. The present work reports a method that could be used to address this issue. It is shown that analysis of post steady state transient filtration data leads to clear demarcation of osmotically limited and gel layer controlled filtration. The method proposed in this work can also be used to estimate the additional filtration resistance offered by the polarization layer to the permeate flow in macromolecular ultrafiltration and has been verified experimentally. It has also been shown that the polarization layer thickness is not sensitive to the feed pressure but varies as a function of the bulk solute concentration; higher the bulk concentration, thicker is the polarization layer.

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Polysulfone membranes. V. Poly(phenyl sulfone) (Radel R)–poly(vinyl pyrrolidone) membranes

Cited by 39 publications

References 11 publications

Effect of additives on release profile of leuprolide acetate in an in situ forming controlled‐release system: In vitro study

Effect of additives on release profile of leuprolide acetate in an in situ forming controlled‐release system: In vitro study

Experimental studies in the dead-end ultrafiltration of dextran: analysis of concentration polarization

A New Method for Identifying Osmotically Limited and Gel Layer Controlled Pressure Independent Flux in Ultrafiltration

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