The article discusses possible methods and modifications for the manufacture of bases for removable lamellar dentures based on acrylic plastic. The use of acrylic resin is still widely used today in orthopedic dentistry. Removable plate dentures made of acrylic plastic have good aesthetic properties, manufacturability, sufficient strength, and, despite the actual toxicity of the residual monomer, the current alternative has not yet been established in world practice. That is why research is ongoing aimed at testing both new alternative materials for the manufacture of prostheses, and modified technologies for the manufacture of prosthesis bases from polymethyl methacrylate. Possible reaction of the mucosa of patients to the residual monomer in the basis of a removable prosthesis justifies the need for further study of options for solving this problem. Based on the literature data, the article considered possible options for replacing plastic with polyetheretherketone, nylon, partial replacement of acrylic plastic with metal. The experience of using topcoat varnishes is analyzed. Comparisons were made between attempts to coat the surface of prostheses with components of essential oil plants, n-butyl acetic acid, and polysulfone-based insulating varnish to reduce toxicological effects. Based on the analysis, conclusions were drawn about the positive and negative results of all previously used methods, and the need for further research in this direction was justified.