Polysynovitis after Oligofructose Overload in Dairy Cattle

Danscher, Anne Mette; Enemark, Heidi L.; Andersen, Pia Haubro; Aalbæk, Bent; Nielsen, Ole Lerberg

doi:10.1016/j.jcpa.2009.09.001

Cited by 28 publications

(45 citation statements)

References 17 publications

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“…Oligofructose overload has been shown to induce acute bovine laminitis (Thoefner et al, 2004;Thoefner et al, 2005). Also in the present study, clinical and histological signs of laminitis and synovitis were observed after oligofructose overload as reported elsewhere (Danscher et al, 2009;Danscher et al, 2010b;Danscher et al, 2010a). The acute phase response observed in this study may have originated both from damage to the rumen and the resulting systemic reaction as well as from local damage to the joints and claws or other tissue.…”

Section: Discussionsupporting

confidence: 86%

“…All heifers receiving oligofructose overload developed profound ruminal and systemic acidosis (Danscher et al, 2009;Danscher et al, 2010a). During the second day after oligofructose overload and onwards, clinical signs of acute laminitis were observed (increased locomotion score, reaction to hoof testing and swelling of tarsocrural joints) as described by Danscher et al (2009).…”

Section: Resultsmentioning

confidence: 94%

“…Within blocks the heifers were randomly assigned to 3 groups-OF24: treatment group of 4 animals euthanized 24 h after treatment; OF72: treatment group of 6 animals euthanized 72 h after treatment; and C: control group of 6 animals euthanized 72 or 96 h after treatment. Results of postmortem examinations are reported elsewhere (Danscher et al, 2010a).…”

Section: Designmentioning

confidence: 99%

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Acute phase protein response during acute ruminal acidosis in cattle

et al. 2011

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Section: Discussionsupporting

confidence: 86%

Section: Resultsmentioning

confidence: 94%

Section: Designmentioning

confidence: 99%

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Acute phase protein response during acute ruminal acidosis in cattle

et al. 2011

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“…We demonstrated that heifers treated with an overload of oligofructose had strongly increased lactic acid levels in the ruminal fluid and plasma. It is well known that this metabolic disorder induces the onset of inflammatory processes, such as ruminitis [27], laminitis [26] and polysynovitis [4]. It has been reported that heifers subjected to oligofructose overload develop generalized sterile polysynovitis involving the exudation of fibrin and the mobilization of neutrophils [5].…”

Section: Discussionmentioning

confidence: 99%

Oxidative response of neutrophils to platelet-activating factor is altered during acute ruminal acidosis induced by oligofructose in heifers

et al. 2014

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Reactive oxygen species (ROS) production is one of the main mechanisms used to kill microbes during innate immune response. D-lactic acid, which is augmented during acute ruminal acidosis, reduces platelet activating factor (PAF)-induced ROS production and L-selectin shedding in bovine neutrophils in vitro. This study was conducted to investigate whether acute ruminal acidosis induced by acute oligofructose overload in heifers interferes with ROS production and L-selectin shedding in blood neutrophils. Blood neutrophils and plasma were obtained by jugular venipuncture, while ruminal samples were collected using rumenocentesis. Lactic acid from plasma and ruminal samples was measured by HPLC. PAF-induced ROS production and L-selectin shedding were measured in vitro in bovine neutrophils by a luminol chemiluminescence assay and flow cytometry, respectively. A significant increase in ruminal and plasma lactic acid was recorded in these animals. Specifically, a decrease in PAF-induced ROS production was observed 8 h after oligofructose overload, and this was sustained until 48 h post oligofructose overload. A reduction in PAF-induced L-selectin shedding was observed at 16 h and 32 h post oligofructose overload. Overall, the results indicated that neutrophil PAF responses were altered in heifers with ruminal acidosis, suggesting a potential dysfunction of the innate immune response.

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“…The aim of this experiment was to initiate SARA without impacting animal welfare beyond a point whereby semen could not be collected immediately after the challenge period. Hence, the dose rate used in this study (6.5 g/kg BW) was substantially lower than in previous experiments using oligofructose as the sole substrate, where dosages of 13, 17, or 21 g/ kg BW induced laminitis subsequent to acute ruminal and systemic acidosis (Thoefner et al, 2004;Danscher et al, 2009Danscher et al, , 2010. Despite the comparatively lower dose rate in the current experiment, all bulls receiving oligofructose developed lameness, which persisted for acidosis and laminitis challenge models.…”

Section: Acidosis Induction Modelmentioning

confidence: 65%

Subacute ruminal acidosis reduces sperm quality in beef bulls1

Callaghan

McAuliffe

Rodgers

et al. 2016

Journal of Animal Science

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A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription.For more information, please contact eprints@nottingham.ac.uk 3215 INTRODuCTIONBreeding bulls in Australia are commonly fed high-energy diets before sale, generally in the form of grain. These diets previously have been shown to negatively affect sperm quality in bulls (Coulter phenomenon has been associated with increased adipose tissue deposition in the scrotal neck, impairing thermoregulation via the pampiniform plexus (Kastelic et al., 1996). Elevation of testicular tem--duction and sperm viability (Vogler et al., 1993). However, anecdotal evidence from veterinary practitioners and semen morphology laboratories suggests that sperm production can be affected early in the sale preparation process, before fat deposition occurring (P. McAuliffe, personal communication). The rapid introduction of diets containing readily fermentable carbohydrates may precipitate ruminal acidosis AbSTRACT: Breeding bulls are commonly fed high-energy diets, which may induce subacute rumiGertrudis bulls (age 20 ± 6 mo) were used to evaluate the extent and duration of effects of SARA on semen quality and the associated changes in circulating hormones and metabolites. The bulls were relocated and fed in yards with unrestricted access to hay and daily individual concentrate feeding for 125 d before SARA challenge. Semen was collected and assessed at 14-d intervals before the challenge to ensure acclimatization and the attainment of a stable spermiogram. The challenge treatments consisted of either a single oral dose of oligofructose (OFF; 6.5 g/kg BW) or an equivalent sham dose of water (Control). Locomotion, behavior, respiratory rate, and cardiovascular and gastrointestinal function were intensively monitored during the retained for VFA, ammonia, and lactate analysis. After the challenge, semen was then collected every third day for a period of 7 wk and then once weekly until 12 wk, with associated blood collection for FSH, testosterone, inhibin, and cortisol assay. Percent normal sperm decreased in bulls dosed with OFF after the challenge period (P -lenge. There was a corresponding increase in sperm defects commencing from 16 d after challenge. These included proximal cytoplasmic droplets (P P = 0.01), and vacuole and teratoid heads (P -ity after challenge were associated with lower serum testosterone (P P cortisol in OFF bulls tended to be greater (P = 0.07) at 7 d after challenge. This study shows that SARA chalpreclude bulls from sale as single sire breeding animals 3 mo after the event occurred.

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Polysynovitis after Oligofructose Overload in Dairy Cattle

Cited by 28 publications

References 17 publications

Acute phase protein response during acute ruminal acidosis in cattle

Acute phase protein response during acute ruminal acidosis in cattle

Oxidative response of neutrophils to platelet-activating factor is altered during acute ruminal acidosis induced by oligofructose in heifers

Subacute ruminal acidosis reduces sperm quality in beef bulls1

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