Polytetrafluoroethylene Giant Granuloma and Adenopathy: Long-Term Complications Following Subureteral Polytetrafluoroethylene Injection for the Treatment of Vesicoureteral Reflux in Children

Aragona, Francesco; D’Urso, Leonardo; Scremin, E.; Salmaso, Roberto; Glazel, G. Passerini

doi:10.1016/s0022-5347(01)64275-7

Cited by 55 publications

(17 citation statements)

References 36 publications

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“…PTFE paste injection resulted in particle migration to distant organs, such as the lungs and brain. [22][23][24][25] Although collagen is not likely to migrate, collagen did not conserve the initial volume 26,27 and sometimes caused allergic reactions or viral infections. 28 Silicone has been reported to have severe complications, such as chronic inflammation or migration.…”

Section: Introductionmentioning

confidence: 99%

The effect of microsphere degradation rate on the efficacy of polymeric microspheres as bulking agents: An 18‐month follow‐up study

et al. 2006

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The injection of bulking substances has been proposed as a new therapy to treat urinary incontinence and vesicoureteral reflux. Our previous study demonstrated that poly(lacticco-glycolic acid) (PLGA) microspheres have the potential to serve as a bulking agent for urological injection therapies. Hybrid tissues exhibiting a bulking effect were formed in vivo by PLGA microsphere injection, but long-term volume stability was not proven. In this study, we hypothesized that the biodegradation rate of the bulking substance (polymer microspheres) would affect the duration of volume conservation of the induced hybrid tissue. To test this hypothesis, rapidly degrading 75:25 PLGA microspheres and slowly degrading poly(L-lactic acid) (PLLA) microspheres were used as injectable bulking agents for the injection therapy. In vitro degradation tests showed that the mass losses of PLLA and PLGA were 16 and 96% of the initial masses, respectively, at 30 weeks. PLLA and PLGA microspheres were injected into the subcutaneous dorsum of mice. Both types of microspheres were easily injectable through 24-gauge needles. Histological examinations at various time points indicated that host cells from the surrounding tissues migrated to the spaces between both types of injected microspheres and formed new hybrid tissue structures. Lymphocyte migration was noted around the implanted PLGA and PLLA microspheres, but the inflammatory reaction diminished with time. Importantly, the volume of the PLLA hybrid tissues slowly decreased to 52% of the initial volume at 12 months and maintained that volume until 18 months, whereas the volume of the PLGA hybrid tissues rapidly decreased to 22% at 6 months, and the PLGA hybrid tissues disappeared at 11 months. These results show that the biodegradation rate of the bulking substance may be useful for controlling the duration of volume conservation of the induced hybrid tissue.

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Section: Introductionmentioning

confidence: 99%

The effect of microsphere degradation rate on the efficacy of polymeric microspheres as bulking agents: An 18‐month follow‐up study

et al. 2006

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“…still have high morbidity, little efficacy and formation of antibodies cloms and migrate [17][18][19][20].…”

Section: Page 4 Ofmentioning

confidence: 99%

Endoscopic Treatment of the Vesicoureteral Reflux by Electrocoagulation

Saed¹

2017

JURNOA

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Purpose: We reviewed our experience with endoscopic treatment of Vesicoureteric Reflux (V.U.R) by electrocoagulation; as a simple technique to determine the efficacy and lack of morbidity of this procedure. Material and methods:Between January 1998 and December 2002, 150 patients with vesicoureteric reflux (210 refluxing ureter) underwent 291 endoscopic electrocoagulation in the hemitrigone in order to treat the reflux. Male to female ratio was 2:8. Age ranged from 2 months to 47 years, median: 7 years. Localization was bilateral 39% Rt. Side 20%, Lt Side 41%. The grade of vesicoureteric reflux ranged from 2 to 5th grade. Secondary reflux was in 18% of the cases. Results:Good results achieved in 85% of patients, 25% of the patients underwent repeated coagulation (2-3 times). 12% underwent surgical treatment because of the associated abnormalities (paraureteral vesical diverticulum, ectopic ureterocele, posterior urethral valves, ureteral duplication etc.). Conclusions:Endoscopic treatment of V.U.R. by electrocoagulation is a simple and safe procedure, with less morbidity, and it is cost effective.

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“…The organs of the microsphere-implanted mice, including the liver, brain, heart, spleen, kidneys, and lungs, were also harvested and examined histologically to determine microsphere migration to the distant organs. Figure 1) in a CMC solution were injected through various gauges (18,20,24, and 26-gauge) of needles to determine whether the microspheres were injectable without morphological deformation. The microspheres were injected easily through all types of the gauge needles and showed no tendency to obstruct the needles.…”

Section: Analysesmentioning

confidence: 99%

“…PTFE paste injection resulted in particle migration to distant organs, such as lungs and brain. [17][18][19][20] Since PTFE particles are nonbiodegradable, concerns about chronic side effects have been raised. Furthermore, particles that spread to distant organs cannot be removed by a simple operation.…”

Section: Introductionmentioning

confidence: 99%

Poly(lactic‐co‐glycolic acid) microspheres as a potential bulking agent for urological injection therapy: Preliminary results

2004

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Injection of bulking substances has been introduced as a new therapy to treat urinary incontinence and vesicoureteral reflux. Currently available bulking substances for the injection therapies include liquid or particulated silicone, collagen gel, and polytetrafluoroethylene paste. However, these materials have shown shortcomings such as inflammation, rapid volume decrease, and particle migration to distant organs. In the present study, we evaluated poly(lactic-co-glycolic acid) (PLGA) microspheres as a potential injectable bulking agent for the injection therapies. PLGA microspheres (52 m in average diameter) were injectable through various gauges of needles, as the injected microspheres showed no tendency to obstruct the needles and microsphere size exclusion was not observed upon injection through the needles. After injection of PLGA microspheres into the subcutaneous dorsum of mice, inflammation, new tissue volume change, and microsphere migration were examined. Host cells from the surrounding tissues migrated to the implanted microspheres and formed new hybrid tissue structures. The volume of the newly generated tissues was maintained approximately constant for 7 weeks. Histological analyses showed no evidence of migration of the implanted microspheres to the distant organs. In summary, PLGA microspheres were injectable and able to induce a new hybrid tissue formation without initial volume decrease or particle migration. These preliminary results suggest that this material may be a potentially useful bulking agent for urological injection therapies.

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Polytetrafluoroethylene Giant Granuloma and Adenopathy: Long-Term Complications Following Subureteral Polytetrafluoroethylene Injection for the Treatment of Vesicoureteral Reflux in Children

Cited by 55 publications

References 36 publications

The effect of microsphere degradation rate on the efficacy of polymeric microspheres as bulking agents: An 18‐month follow‐up study

The effect of microsphere degradation rate on the efficacy of polymeric microspheres as bulking agents: An 18‐month follow‐up study

Endoscopic Treatment of the Vesicoureteral Reflux by Electrocoagulation

Poly(lactic‐co‐glycolic acid) microspheres as a potential bulking agent for urological injection therapy: Preliminary results

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