Polyunsaturated Fatty Acid Diet and Upregulation of Lipoxin A4 Reduce the Inflammatory Response of Preeclampsia

Abstract

The aim of this study was to investigate the effects and mechanisms of polyunsaturated fatty acids (PUFAs) and lipoxin A4 (LXA4) on preeclampsia (PE). The LXA4 level was significantly reduced in PE rats. The PUFA diet upregulated the expressions of lipoxygenase 12 (LOX12) and lipoxygenase 15 (LOX15) and downregulated those of cyclooxygenase-2, tumor necrosis factor-α (TNF-α), and endoglin. Lipopolysaccharides could inhibit cell growth and cause inflammatory response, while the presence of PUFAs inhibited the inflammatory response and promoted the expressions of LOX12, LOX15, and LXA4. Nordihydroguaiaretic acid (NDGA) regulated LXA4 expression and inflammation levels by affecting LOX. Inhibition of lipoxygenase 5 activity by NDGA upregulated the expressions of LOX12 and LOX15, while LXA4 reversed LXA4, nitric oxide downregulation, and TNF-α upregulation by NDGA. A decrease in LXA4 levels played an important role in the development and progression of PE.

Association of dietary inflammatory index with risk of gestational diabetes mellitus and preeclampsia: a systematic review and meta-analysis

“…It is rich in dietary fibre, vitamin C, vitamin E, folate, carotenoids and PUFA. Previous studies have shown that greater intake of the Mediterranean diet during pregnancy is associated with a reduced risk of GDM and PE (32–35) . The Western diet, characterised by a greater intake of red meat, processed meat and fried foods, is rich in SFA, nitrosamines and other compounds related to oxidative stress and insulin resistance, which may increase the level of serum inflammatory markers (36,37) .…”

Fibroblast Growth Factor 19 Improves LPS-Induced Lipid Disorder and Organ Injury by Regulating Metabolomic Characteristics in Mice

“…We suspected that LPS-induced LA metabolism disturbance is earlier than organ injury. Accumulated evidences indicated that USFA are substrates for the synthesis of multiple molecules that are active in inflammatory response [45][46][47][48]. Decreased Omega 6/Omega 3 FAs were proved to attenuate ethanol-induced liver injury [49].…”

Expression profiles of circular RNA in human placental villus and decidua and prediction of drugs for recurrent spontaneous abortion

“…As a representative chemical, the effects of NDGA on RSA are unclear; however, they are considered potentially relevant. NDGA regulates the expression of lipoxin A4 and inflammation levels, by affecting lipoxygenase, and influences the onset and development of preeclampsia 55 . This suggests that NDGA may play an important role in embryonic development.…”

“…NDGA regulates the expression of lipoxin A4 and inflammation levels, by affecting lipoxygenase, and influences the onset and development of preeclampsia. 55 This suggests that NDGA may play an important role in embryonic development. However, we only examined one chemical and may have overlooked some valuable active compounds.…”