Polyunsaturated Fatty Acids in Adult Psychiatric Disorders: A Comprehensive Overview

Saah, Tammy; Garlow, Steven J.; Rapaport, Mark Hyman

doi:10.1007/978-3-319-13602-8_18

Cited by 3 publications

(3 citation statements)

References 105 publications

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“…A multitude of RCTs have investigated the immunomodulation benefits of omega‐3 fatty acid (FA) supplementation as adjunctive treatment for psychiatric conditions . In addition to their essential role in cell membrane integrity and fluidity, omega‐3 FAs are generally considered anti‐inflammatory.…”

Section: Therapeutically Targeting Inflammationmentioning

confidence: 99%

Mental health is the health of the whole body: How psychoneuroimmunology & health psychology can inform & improve treatment

Alessi

Bennett

2020

Evaluation Clinical Practice

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Background: Converging and accumulating evidence for the cross-communication among the nervous, immune, and endocrine systems, a field of study known as psychoneuroimmunology, implicates immunological dysfunction as a shared and common mechanism of both mental and physical illness. For example, psychiatric disorders like schizophrenia, bipolar disorder, major depression, and anxiety disorders have higher prevalence rates across a spectrum of autoimmune conditions compared to the general population. Additionally, subclinical immunological abnormalities are observed in a variety of psychiatric conditions, with chronic inflammation most extensively studied in the pathophysiology of depression. These observations blur the historical distinctions between mental and physical illness, yet clinical practice remains fragmented and primarily focused on differentially treating individual symptoms. Proposed thesis: Therapeutically targeting inflammation offers translational opportunities for integrating mental and physical healthcare, a key niche of the interdisciplinary field of health psychology. Conclusion: Utilizing a psychoneuroimmunological lens, health psychologists and clinicians can reconceptualize healthcare through integrative treatment approaches and advocacy for comprehensive policy-level reform at both the individual-level of care as well as community-wide prevention approaches. K E Y W O R D S health psychology, immune health, mental health, psychoneuroimmunology Mental and physical disorders are often conceptualized and treated as distinct diagnoses with unique etiologies, stemming from the mindbody dualism that underlies much of modern medical biology. 1 The emergence of psychoneuroimmunology, or study of the crosscommunication between the nervous, immune, and endocrine systems, is increasingly blurring the historical distinctions between mental and physical illness as converging and accumulating evidence suggests immune dysfunction and systemic inflammation are commonly observed across many psychiatric conditions. 2-4 Despite this growing body of scientific knowledge, clinical practice remains fragmented and primarily focused on differentially treating disparate symptoms. Psychoneuroimmunology provides a framework for integrating mental and physical healthcare, a key niche of the growing interdisciplinary field of health psychology. This paper describes some of the existing literature documenting the overlap between immune function and mental health and suggests potential clinical implications of a psychoneuroimmunological lens for both individual-level of care as well as community-wide approaches.

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Section: Therapeutically Targeting Inflammationmentioning

confidence: 99%

Mental health is the health of the whole body: How psychoneuroimmunology & health psychology can inform & improve treatment

Alessi

Bennett

2020

Evaluation Clinical Practice

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“…There is limited evidence that suggest a beneficial effect of omega-3 PUFAs on depression where they decrease the symptoms [10]. Furthermore, studies have showed that individuals at risk of developing psychotic disorders might benefit from omega-3 supplementation [2]. Overall, there seems to be a positive effect of omega-3 PUFA on cognitive performance and mood enhancement across ages.…”

Section: Cognitive Performance and Mood Disorders In Adultsmentioning

confidence: 99%

“…The position of the double bond that is closest to the methyl end of the fatty acid chain classifies PUFAs into two groups: the omega-3, where this double bond is found three carbon atoms away from the methyl group, and the omega-6, where the double bond is six carbon atoms away from the methyl group. These two groups, although structurally similar, have very different biological activities [1][2][3]. Ongoing research has shown that omega-3 PUFAs have a beneficial effect, while omega-6 could contribute to diseases like obesity, inflammation and cardiovascular disease [3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Polyunsaturated Fatty Acids as Dietary Supplements: Biological Activities and Sources

Hardman¹,

Fakas²

2016

Int J Clin Nutr Diet

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Polyunsaturated fatty acids (PUFAs) have been used as dietary supplements for quite some time with various health claims. Major dietary PUFAs are classified as omega-3 and omega-6 based on their structure, and these fatty acids are considered essential nutrients. The two classes of PUFAs, although structurally similar, present different biological activities that can be beneficial or detrimental to humans. Some of these biological activities have been known for a long time, while others are emerging from the plethora of dietary studies done on PUFAs. Yet many of the health claims for PUFAs are still debated, with the findings being conflicting. This review summarizes our current knowledge on the biological activities of PUFAs and discusses the dietary sources available. In light of new dietary recommendations, PUFA consumption is on the rise, so new dietary sources for these fatty acids are needed.

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Inflammation, insulin resistance and the pathophysiology of depression: implications for novel antidepressant developments

Leonard¹,

Arıcıoğlu²

2020

PCP

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Polyunsaturated Fatty Acids in Adult Psychiatric Disorders: A Comprehensive Overview

Cited by 3 publications

References 105 publications

Mental health is the health of the whole body: How psychoneuroimmunology & health psychology can inform & improve treatment

Mental health is the health of the whole body: How psychoneuroimmunology & health psychology can inform & improve treatment

Polyunsaturated Fatty Acids as Dietary Supplements: Biological Activities and Sources

Inflammation, insulin resistance and the pathophysiology of depression: implications for novel antidepressant developments

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