Polyunsaturated Fatty Acids in Cystic Fibrosis Are Related to Nutrition and Clinical Expression of the Disease

Walkowiak, Jarosław; Lisowska, Aleksandra; Błaszczyński, Michał; Przysławski, Juliusz; Walczak, Mieczysław

doi:10.1097/mpg.0b013e3180690da9

Cited by 18 publications

(20 citation statements)

References 10 publications

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“…The abnormalities in FAs' profile are known to occur in CF patients and were also confirmed by previous research [19,20,21,31]. However, data is still lacking on the relationship between the presence of comorbidities and FA composition.…”

Section: Discussionsupporting

confidence: 69%

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Serum Phospholipid Fatty Acid Composition in Cystic Fibrosis Patients with and without Liver Cirrhosis

Drzymała-Czyż

Szczepanik²,

Krzyżanowska³

et al. 2017

Ann Nutr Metab

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Background/Aims: Cystic fibrosis (CF) liver disease is the third most frequent cause of death in CF patients. Although it alters fatty acid (FA) metabolism, data concerning the profile of FA in CF patients with liver cirrhosis is lacking. This study aimed to assess the FA composition of serum phospholipids in CF patients with and without liver cirrhosis. Methods: The study comprised 25 CF patients with liver cirrhosis and 25 without it. We assessed Z-scores for body height and weight, lung function, exocrine pancreatic sufficiency and colonization with Pseudomonas aeruginosa. FAs' profile of serum glycerophospholipids was quantified by gas chromatography mass spectrometry. Results: In CF patients with liver cirrhosis, the levels of C16:0 were higher and the amounts of C20:2n-6, C20:3n-6, C20:4n-6, and all the n-3 polyunsaturated FAs (PUFAs) (C18:3n-3, C20:5n-3, C22:5n-3, C22:6n-3) were lower than those in CF subjects without liver cirrhosis. The n-6/n-3, C20:4n-6/C18:2n-6, total n-6/C18:2n-6, C20:5n-3/C18:3n-3 and total n-3/C18:3n-3 ratios did not differ between the 2 groups. Conclusions: Liver cirrhosis may associate with profound abnormalities in the composition of serum glycerophospholipids FAs in CF patients. None of the analyzed clinical factors could explain the greater prevalence of low levels of PUFAs in this CF subgroup.

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Section: Discussionsupporting

confidence: 69%

“…Low levels of the essential FAs C18:2n-6 (linoleic acid, LA) and C22:6n-3 (docosahexaenoic acid, DHA) and a compensatory increase in the proportion of non-essential monoenoic and eicosatrienoic FAs were described [19,20,21]. Data concerning the profile in CF patients with liver cirrhosis is lacking.…”

Section: Introduction and Aimsmentioning

confidence: 99%

Serum Phospholipid Fatty Acid Composition in Cystic Fibrosis Patients with and without Liver Cirrhosis

Drzymała-Czyż

Szczepanik²,

Krzyżanowska³

et al. 2017

Ann Nutr Metab

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“…There were no associations between type of dietary fat intake and serum LA and DHA in either of these prior studies (28,29). Specifically, dietary LA intake has been previously reported to influence serum LA status in infants with CF (12), as well as in children of 6 to 18 years with CF (11); logistic regression and multiple regression analyses were used, respectively, in these specific studies. The relationships between other types of dietary fats and serum LA and other FA of interest, however, were not reported.…”

Section: Discussionmentioning

confidence: 99%

Relation Between Dietary Fat Intake Type and Serum Fatty Acid Status in Children With Cystic Fibrosis

Maqbool

Schall²,

Gallagher³

et al. 2012

J. pediatr. gastroenterol. nutr.

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Background and Objective Children with cystic fibrosis (CF) and pancreatic insufficiency (PI) are at risk for fatty acid (FA) abnormalities and essential FA deficiency, with low linoleic acid (LA) and docosahexaenoic acid (DHA) concentrations and abnormal triene:tetraene (T:T) and arachidonic acid (AA):DHA ratios. The aim of the article was to determine whether type of dietary fat predicted serum LA, DHA, T:T, and AA:DHA ratios in subjects with CF and PI as compared to an unaffected comparison group. Methods Serum FA concentrations were assessed by capillary gas-liquid chromatography (mol%) and dietary intake by 7-day weighed food records; the 3-day coefficient of fat absorption was calculated. Total energy intake was expressed in kilocalories. Results A total of 65 subjects with CF and PI (8.4 ± 1.0 years, 32 girls) and 22 controls (8.5 ± 1.1 years, 13 girls) were included. Despite greater energy, saturated fat, and LA intake, the subjects with CF had lower serum LA and DHA and higher T:T and AA:DHA than those in the comparison group. Dietary total fat, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), LA, total ω 6 polyunsaturated fatty acid (Tω6PUFA), and α-linolenic acid (ALA) intake positively predicted serum LA concentration. MUFA, total ω 3 polyunsaturated fatty acid (Tω3PUFA), and ALA intake positively predicted serum DHA concentration. Total dietary fat, MUFA, PUFA, Tω3PUFA, LA, and ALA intake negatively predicted serum T:T. ALA and Tω3PUFA intake negatively predicted serum AA:DHA. Conclusions Dietary fat patterns influenced serum LA, DHA, T:T, and AA:DHA in children with CF and PI. These data suggest that changes in dietary practices may result in FA profiles associated with improved clinical outcomes.

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“…The current study included seventy children and they were ( 20 ) children with untreated Celiac disease , ( 20 ) children with Cystic fibrosis ( 10 ) of them were taken treatment for over than three years and the other ( 10 ) children were not treated yet , while the control group in this study were 30 children Table ( 1 ) revealed that the mean values of Linoleic acid was significantly higher in CF patients who were taking treatment as compared to control , while there were a highly significant reduction in CF group who were not treated and in untreated celiac disease group as compared to control (p < 0.001 )…”

Section: Results:-mentioning

confidence: 99%

“…The patients age was between ( 2 -18 ) years and they were ( 20 ) children with CD , ( 20 ) children with CF , and ( 30 ) control children All of these children were fasting and all of them except the control were born from relative parents who were not educated or only finishing primary school . All patients were examined clinically and diagnosed by pediatrician.…”

Section: Materials and Methods:-mentioning

confidence: 99%

Linoleic and Oleic Acid Level in Iraqi Children With Cystic Fibrosis and Celiac Disease.

Ali¹,

F²,

Arif³

2016

IJAR

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Polyunsaturated Fatty Acids in Cystic Fibrosis Are Related to Nutrition and Clinical Expression of the Disease

Cited by 18 publications

References 10 publications

Serum Phospholipid Fatty Acid Composition in Cystic Fibrosis Patients with and without Liver Cirrhosis

Serum Phospholipid Fatty Acid Composition in Cystic Fibrosis Patients with and without Liver Cirrhosis

Relation Between Dietary Fat Intake Type and Serum Fatty Acid Status in Children With Cystic Fibrosis

Linoleic and Oleic Acid Level in Iraqi Children With Cystic Fibrosis and Celiac Disease.

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