Polyunsaturated fatty acids. Is there a role in postmenopausal osteoporosis prevention?

Albertazzi, Paola; Coupland, Keith

doi:10.1016/s0378-5122(02)00022-1

Cited by 93 publications

(66 citation statements)

References 47 publications

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“…In this study, linolenic acid, representing the biggest part of total n-3 PUFA in the diet of study subjects, significantly associated with a higher BMD at lumbar spine and total body. This is in line with the suggested beneficial effect of n-3 fatty acids on bone health (Albertazzi and Coupland, 2002;Högström et al, 2007;Salari et al, 2008). In contrast to the results of studies reporting no association between the total PUFA intake and BMD (Trichopoulou et al, 1997) or even suggesting decreased BMD with higher PUFA intakes (Macdonald et al, 2004) or linoleic acid (Eriksson et al, 2009;Farina et al, 2011a), we found positive relationships also between the intakes of linoleic acid, total n-6 fatty acids and total PUFA with BMD.…”

Section: Discussionsupporting

confidence: 85%

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Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women

et al. 2011

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Background/Objectives: Significance of dietary fatty acids on bone health is not clear, and the evidence is controversial. This study aimed to investigate the relationship between dietary polyunsaturated fatty acids (PUFAs) and bone mineral density (BMD) among elderly women. Subjects/Methods: Subjects (n ¼ 554) were drawn from the Kuopio OSTPRE Fracture Prevention Study. At baseline they filled a 3-day food record and a questionnaire on lifestyle factors, diseases and medications. BMD was measured at lumbar spine (L2-L4), femoral neck and total body by dual energy X-ray absorptiometry at baseline and after 3 years. The associations between dietary fatty acids and BMD were analyzed by a linear mixed model adjusting for potential dietary and non-dietary confounders. Results: Our findings suggested a positive relationship between the dietary PUFAs and BMD at lumbar spine and in total body but not at femoral neck. Further analyses revealed that these results were due to associations among the women without hormone therapy (HT) at baseline. Among them, the intake of total PUFAs as well the intakes of linoleic and linolenic acids and total n-3 and n-6 fatty acids were significantly associated with BMD at lumbar spine; P for trend over the quartiles ranged between 0.013 and 0.001. Similarly, significant associations were demonstrated for total body BMD and fatty acids with an exception of total PUFA. No significant associations were found among women with HT at baseline. Conclusions: Our findings among elderly women without HT support the suggested beneficial effect of dietary PUFAs on bone health.

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Section: Discussionsupporting

confidence: 85%

“…Also, it may be noted that the intake of PUFAs was rather low, that is, the mean intakes of linoleic acid and total n-3 fatty acids were 3.4% and 1% of energy, respectively. Both n-6 and n-3 fatty acids are needed in bone metabolism, however, the amount and their optimal ratio for bone health in not yet known (Albertazzi and Coupland, 2002).…”

Section: Discussionmentioning

confidence: 99%

Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women

et al. 2011

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“…Recent investigations indicate that the type and amount of PUFA influence bone formation and osteoblastic cell functions (Watkins et al, 2003), with evidence of an adverse effect for omega-6 PUFA (Watkins et al, 2000;Macdonald et al, 2004). Also, the intake of omega-6 fatty acids has been previously shown to be associated with a lower bone mineral density, and a high ratio of omega-6 to omega-3 has been reported to be detrimental for bone formation (Albertazzi and Coupland, 2002). In the Rancho Bernardo Study, after assessing bone mineral density in 1532 community-dwelling men and women aged 45-90 years, an increasing ratio of total dietary omega-6 to omega-3 fatty acids was significantly and independently associated with lower bone mineral density (Weiss et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Dietary fat intake and the risk of osteoporotic fractures in the elderly

et al. 2007

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Objective: To explore the association between fat intake, serum lipids and the risk of osteoporotic fractures in the elderly. Design: A hospital-based case-control study. Setting: The study was conducted at a tertiary centre and referral hospital for the province of Jaén (Spain). Subjects: Cases (n ¼ 167) were patients aged 65 years or more with a low-energy fracture selected from the population attended at the hospital. Controls (patients without antecedents of any fracture) were 1:1 matched to cases by sex and age (n ¼ 167). Methods: Diet was assessed by a semiquantitative food frequency questionnaire. Serum total cholesterol and high-density lipoprotein (HDL) cholesterol were also measured. Results: Participants in the two upper quartiles of polyunsaturated fat (PUFA) intake showed an increased risk of fracture, with statistically significant differences with respect to the first quartile in the adjusted model (odds ratio (OR) ¼ 3.59; 95% confidence interval (CI) ¼ 1.06-12.1 and OR ¼ 5.88; 95% CI ¼ 1.38-25.02); P ¼ 0.01 for the trend test). A higher ratio of monounsaturated fat (MUFA) to PUFA was associated with a reduced risk of fracture (OR ¼ 0.20; 95% CI ¼ 0.07-0.60 for the fourth quartile; P ¼ 0.002 for the trend test). The intake of omega-6 fatty acids was associated with an elevated risk of fracture (OR ¼ 3.41; 95% CI ¼ 1.05-11.15 for the fourth quartile; P ¼ 0.01 for the trend test). HDL-cholesterol levels were inversely associated with the risk of fracture (test for trend P ¼ 0.03 across quartiles). Conclusions: PUFA intake was associated with an increased risk of osteoporotic fractures in the elderly, whereas a high ratio of MUFA:PUFA was associated with decreased risk.

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“…FA 18:2n-6 and18:1n-9 is considered as high nutritional because of their protective role against cardiovascular diseases [86]. N-3 PUFAs is also directly connected to preventing of immunologic diseases [87] as well as decreasing chronically neurodegenerative diseases [88], rheumatoid arthritis, osteoporosis [89]. Stearidonic acid (18:4n-3, SA) that constitutes the first metabolite of ALA in the metabolic pathway leading to the endogenous production of eicosapentaenoic acid (20:5n-3, EPA) and docosahexaenoic acid (22:6n-3) [90].…”

Section: S Pallidum As Source Of Important Fatty Acids and His Nutrimentioning

confidence: 99%

Seasonal Composition of Lipids, Fatty Acids Pigments in the Brown Alga <i>Sargassum pallidum</i>: The Potential for Health

Gerasimenko¹,

Logvinov²

2016

OJMS

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The present study describes the content of total lipids (TL), the main components of polar and neutral lipids (NL) and photosynthetic pigments (PSP) in edible seaweed Sargassum pallidum (Ochrophyta) from the Sea of Japan, Russia, in different months of the year, taking into account life cycle. Special attention was paid to the fatty acids (FAs) of total lipids as well as the accumulation of important polyunsaturated fatty acids (PUFAs) in glyceroglycolipids (GL) and reserve lipids in the seasonal cycles of growth. The content of TL strongly varied in the course of a year. The major lipid components were GL (20.3% -36.4%) and NL (19.8% -30.6%), while phospholipids (PL) were present in negligible amounts (3.2% -6.9%). Significant seasonal variations were observed in content all classes of lipids. The PUFAs prevailed in total lipids and the content of n-6 PUFAs was higher than n-3 PUFAs on all stages of life with the exception of vegetation period. Monogalactosyldiacylglycerols (MGDG) and digalactosyldiacylglecerols (DGDG) were rich in PUFAs and n-3 PUFAs were dominated among them independently of stages of growth. Saturated fatty acids (SFA) were dominated in sulfoquinovosyldiacylglycerols (SQDG). Triacylglycerols (TAG) and diacylglycerols (DAG) contained many PUFAs, especially n-6 PUFAs. Significant concentration 20:3 n-6 was in the triacylglycerols. The concentration of chlorophylls and carotenoids was increased with the growth and maturation of S. pallidum and reached maximum in period of highest day length and water temperature. The content of pigments decreased with the onset of short days and decreasing water temperatures. Nutritional value and benefit for health of human this alga were evaluated. The n-6/n-3 PUFAs ratio, nutritional quality index (atherogenic and thrombogenic indices, and ratio between hypocholesterolemic and hypercholesterolemic fatty acids) were low, suggesting a high nutritional value of S. pallidum throughout the year.

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Polyunsaturated fatty acids. Is there a role in postmenopausal osteoporosis prevention?

Cited by 93 publications

References 47 publications

Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women

Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women

Dietary fat intake and the risk of osteoporotic fractures in the elderly

Seasonal Composition of Lipids, Fatty Acids Pigments in the Brown Alga <i>Sargassum pallidum</i>: The Potential for Health

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Polyunsaturated fatty acids. Is there a role in postmenopausal osteoporosis prevention?

Cited by 93 publications

References 47 publications

Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women

Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women

Dietary fat intake and the risk of osteoporotic fractures in the elderly

Seasonal Composition of Lipids, Fatty Acids Pigments in the Brown Alga &lt;i&gt;Sargassum pallidum&lt;/i&gt;: The Potential for Health

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Seasonal Composition of Lipids, Fatty Acids Pigments in the Brown Alga <i>Sargassum pallidum</i>: The Potential for Health