1995
DOI: 10.1093/ajcn/62.2.392
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Polyunsaturated fatty acids result in greater cholesterol lowering and less triacylglycerol elevation than do monounsaturated fatty acids in a dose-response comparison in a multiracial study group

Abstract: Cholesterol-lowering effects of polyunsaturated and monounsaturated fatty acids were compared as they were varied in a reciprocal dose-dependent fashion in the context of a National Cholesterol Education Program (NCEP) Step 1 diet. The study population comprised 63 moderately hypercholesterolemic African American and white men and women. After a 6-wk baseline diet containing 37% of energy from total fat and 15% from saturated fat, participants consumed four diets for 6 wk each, in random order, containing 10% … Show more

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Cited by 72 publications
(42 citation statements)
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“…Results from two carefully controlled studies using liquid formula diets indicate that polyunsaturated fat decreases high density lipoprotein cholesterol concentrations (Mattson & Grundy, 1985;Vega et al, 1982). This is in contrast to studies that have noted no change in high density lipoprotein cholesterol concentrations when feeding either liquid formula or solid foods rich in polyunsaturated fat (Becker et al, 1983;Howard et al, 1995;Mensink & Katan, 1989).…”
Section: Introductioncontrasting
confidence: 99%
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“…Results from two carefully controlled studies using liquid formula diets indicate that polyunsaturated fat decreases high density lipoprotein cholesterol concentrations (Mattson & Grundy, 1985;Vega et al, 1982). This is in contrast to studies that have noted no change in high density lipoprotein cholesterol concentrations when feeding either liquid formula or solid foods rich in polyunsaturated fat (Becker et al, 1983;Howard et al, 1995;Mensink & Katan, 1989).…”
Section: Introductioncontrasting
confidence: 99%
“…Replacing saturated fat with polyunsaturated fat produces a slightly larger decrease in total cholesterol than with monounsaturated fat; however, the effect on high density lipoprotein cholesterol is uncertain (Becker et al, 1983;Gustafsson et al, 1992;Howard et al, 1995;Mattson & Grundy, 1985;Mensink & Katan, 1989;Vega et al, 1982;Wardlaw & Snook, 1990). Results from two carefully controlled studies using liquid formula diets indicate that polyunsaturated fat decreases high density lipoprotein cholesterol concentrations (Mattson & Grundy, 1985;Vega et al, 1982).…”
Section: Introductionmentioning
confidence: 99%
“…40 Overall, women had a slightly greater response to the diets, with an average LDL cholesterol decline of 9.5 AE 16.2 mg/dl (0.25 AE 0.42 mmol/l), compared to 6.2 AE 15.1 mg/dl (0.16 AE 0.39 mmol/l) for men, but this difference was not statistically signi®cant.…”
Section: Resultsmentioning
confidence: 84%
“…Participants' self-reports of compliance revealed no difference between lean and obese subjects or between men and women. 40 The VLDL fatty acid content of 18:2 also correlated with dietary treatment, P`0.0001 (data not shown). Therefore, poor dietary compliance did not appear to explain differences in dietary response.…”
Section: Discussionmentioning
confidence: 85%
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