Polyurethane dispersion containing quaternized ammonium groups: An efficient nanosize gene delivery carrier for A549 cancer cell line transfection

Marzbali, Mahsa Yousefpour; Khosroushahi, Ahmad Yari; Movassaghpour, Aliakbar; Yeganeh, Hamid

doi:10.1016/j.cbi.2015.11.028

Cited by 11 publications

(2 citation statements)

References 64 publications

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“…applied as biomaterials . The ionic structure of the polyurethane chain provides additional opportunities for introduction of antibacterial polar groups and is active in nonviral cancer gene therapy polar groups . A prospective biomedical application has chitosan‐based polyurethane anionomers .…”

Section: Introductionmentioning

confidence: 99%

“…[1] The ionic structure of the polyurethane chain provides additional opportunities for introduction of antibacterial polar groups [2] and is active in nonviral cancer gene therapy polar groups. [3,4] A prospective biomedical application has chitosanbased polyurethane anionomers. [5] Polyurethane ionomers due to strong polar interactions within the rigid segments also allow to obtain novel polymer electrolytes and coatings with microwave absorption properties.…”

Section: Introductionmentioning

confidence: 99%

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Polyurethane cationomers modified by polysiloxane

Król

Pielichowska

Chmielarz

2017

Polymers for Advanced Techs

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The synthesis of waterborne polyurethane cationomers was successfully carried out. Different proportions of α,ω‐di(hydroxyl)polydimethylsiloxane (PDMS) modifier (0–7.3% by weight) were applied. Analysis of IR spectra confirmed the structure of obtained polyurethane cationomers and the incorporation of a modifier into the polyurethane structure. The differential scanning calorimetry (DSC) method was employed for the microstructural assessment of the obtained materials. A clear decrease of the degradation temperature with increasing amounts of incorporated PDMS indicates immiscibility part of the polysiloxane segments with soft segments derived from polyethylene glycol. Changes were discussed in the free surface energy and its components, as calculated independently according to the method suggested by Owens–Wendt, in relation to chemical and physical structures of cationomers as well as morphology of coating surfaces obtained from those cationomers. Test results of contact angle measurements indicated that with increasing content of the polysiloxane in the analyzed films, the contact angles increase. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polyurethane cationomers modified by polysiloxane

Król

Pielichowska

Chmielarz

2017

Polymers for Advanced Techs

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Physicochemical Properties and Biological Performance of Polymethacrylate Based Gene Delivery Vector Systems: Influence of Amino Functionalities

Haladjova

Chrysostomou

Petrova

et al. 2020

Macromolecular Bioscience

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Physicochemical characteristics and biological performance of polyplexes based on two identical copolymers bearing tertiary amino or quaternary ammonium groups are evaluated and compared. Poly(2‐(dimethylamino)ethyl methacrylate)‐b‐poly(oligo(ethylene glycol) methyl ether methacrylate) block copolymer (PDMAEMA‐b‐POEGMA) is synthesized by reversible addition fragmentation chain transfer polymerization. The tertiary amines of PDMAEMA are converted to quaternary ammonium groups by quaternization with methyl iodide. The two copolymers spontaneously formed well‐defined polyplexes with DNA. The size, zeta potential, molar mass, aggregation number, and morphology of the polyplex particles are determined. The parent PDMAEMA‐b‐POEGMA exhibits larger buffering capacity, whereas the corresponding quaternized copolymer (QPDMAEMA‐b‐POEGMA) displays stronger binding affinity to DNA, yielding invariably larger in size and molar mass particles bearing greater number of DNA molecules per particle. Experiments revealed that QPDMAEMA‐b‐POEGMA is more effective in transfecting pEGFP‐N1 than the parent copolymer, attributed to the larger size, molar mass, and DNA cargo, as well as to the effective cellular traffic, which dominated over the enhanced ability for endo‐lysosomal escape of PDMAEMA‐b‐POEGMA.

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Multifunctional Magnetic Nanoparticles: An Effective Theranostic Carrier System

Mehta

Pardeshi

2023

Nanomaterial-Based Drug Delivery Systems

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Polyurethane dispersion containing quaternized ammonium groups: An efficient nanosize gene delivery carrier for A549 cancer cell line transfection

Cited by 11 publications

References 64 publications

Polyurethane cationomers modified by polysiloxane

Polyurethane cationomers modified by polysiloxane

Physicochemical Properties and Biological Performance of Polymethacrylate Based Gene Delivery Vector Systems: Influence of Amino Functionalities

Multifunctional Magnetic Nanoparticles: An Effective Theranostic Carrier System

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