Polyurethane porous scaffolds (PPS) for soft tissue regenerative medicine applications

Kucińska-Lipka, Justyna; Gubańska, Iga; Pokrywczyńska, Marta; Cieśliński, Hubert; Filipowicz, Natalia; Drewa, T.; Janik, Helena

doi:10.1007/s00289-017-2124-x

Cited by 13 publications

(10 citation statements)

References 57 publications

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“…Biostable TPUs are widely known and used in medicine as prosthetics, implants, artificial blood vessels, or gene carriers [30]. What is more, the TPUs have been already successfully applied as tissue-engineered scaffold [31], nerve guidance channels [32], breast implants, dialysis membranes, or aortic grafts [33]. Additionally, we have not recorded certified medical-grade TPU filaments available on the market.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Flexible Medical-Grade TPU Filament for Fused Deposition Modeling 3DP Technology

et al. 2018

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The possibility of using additive manufacturing (AM) in the medicine area has created new opportunities in health care. This has contributed to a sharp increase in demand for 3D printers, their systems and materials that are adapted to strict medical requirements. We described herein a medical-grade thermoplastic polyurethane (S-TPU) which was developed and then formed into a filament for Fused Deposition Modeling (FDM) 3D printers during a melt-extrusion process. S-TPU consisting of aliphatic hexamethylene 1,6-diisocyanate (HDI), amorphous α,ω-dihydroxy(ethylene-butylene adipate) (PEBA) and 1,4 butandiol (BDO) as a chain extender, was synthesized without the use of a catalyst. The filament (F-TPU) properties were characterized by rheological, mechanical, physico-chemical and in vitro biological properties. The tests showed biocompatibility of the obtained filament as well as revealed no significant effect of the filament formation process on its properties. This study may contribute to expanding the range of medical-grade flexible filaments for standard low-budget FDM printers.

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Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Flexible Medical-Grade TPU Filament for Fused Deposition Modeling 3DP Technology

et al. 2018

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“…Biostable TPUs are widely known and used in medicine as prosthetics, implants, artificial blood vessels, or gene carriers [27]. What is more, the TPUs have been already successfully applied as tissue engineered scaffold [28] nerve guidance channels [29], breast implants, dialysis membranes or aortic grafts [30]. Additionally, we have not recorded certified medical-grade TPU filaments available on the market.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Flexible Medical-Grade TPU Filament for Fused Deposition Modeling 3DP Technology

Haryńska¹,

Gubańska²,

Kucińska-Lipka³

et al. 2018

Preprint

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The possibility of using additive manufacturing (AM) in the medicine area has created a new opportunities in health care. This has contributed to a sharp increase in demand for 3D printers, their systems and materials that are adapted to strict medical requirements. We described herein a medical-grade thermoplastic polyurethane (S-TPU), which was developed and then formed into a filament for Fused Deposition Modeling (FDM) 3D printers during a melt-extrusion process. S-TPU consisting of aliphatic hexamethylene 1,6-diisocyanate (HDI), amorphous α,ω-dihydroxy(ethylene-butylene adipate) (PEBA) and 1,4 butandiol (BDO) as a chain extender, was synthesized without the use of a catalyst. The filament properties were characterized by rheological, mechanical, physico-chemical and in vitro biological properties. The tests showed biocompatibility of the obtained filament as well as revealed no significant effect of the filament formation process on its properties. This study may contribute to expanding the range of medical-grade flexible filaments for standard low-budget FDM printers.

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“…Biobased PU scaffolds have been extensively studied for vascular applications in the last years due to their specific mechanical properties, biocompatibility and tunable degradability. Various scaffolds forms are described, from films [ 256 , 257 ] to porous foam [ 258 , 259 ] or electrospun fibrous mat [ 260 ]. For instance, biobased PUs networks were prepared with a lysine triisocyanate PEG prepolymer with a previously synthesized polyester triol from glycerol, ε-caprolactone, D,L lactide and glycolide [ 261 , 262 ].…”

Section: Biobased Pu For Biomedical Applicationsmentioning

confidence: 99%

Biobased polyurethanes for biomedical applications

Wendels

Avérous

2021

Bioactive Materials

241

173

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Polyurethanes (PUs) are a major family of polymers displaying a wide spectrum of physico-chemical, mechanical and structural properties for a large range of fields. They have shown suitable for biomedical applications and are used in this domain since decades. The current variety of biomass available has extended the diversity of starting materials for the elaboration of new biobased macromolecular architectures, allowing the development of biobased PUs with advanced properties such as controlled biotic and abiotic degradation. In this frame, new tunable biomedical devices have been successfully designed. PU structures with precise tissue biomimicking can be obtained and are adequate for adhesion, proliferation and differentiation of many cell's types. Moreover, new smart shape-memory PUs with adjustable shape-recovery properties have demonstrated promising results for biomedical applications such as wound healing. The fossil-based starting materials substitution for biomedical implants is slowly improving, nonetheless better renewable contents need to be achieved for most PUs to obtain biobased certifications. After a presentation of some PU generalities and an understanding of a biomaterial structure-biocompatibility relationship, recent developments of biobased PUs for non-implantable devices as well as short- and long-term implants are described in detail in this review and compared to more conventional PU structures.

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Polyurethane porous scaffolds (PPS) for soft tissue regenerative medicine applications

Cited by 13 publications

References 57 publications

Fabrication and Characterization of Flexible Medical-Grade TPU Filament for Fused Deposition Modeling 3DP Technology

Fabrication and Characterization of Flexible Medical-Grade TPU Filament for Fused Deposition Modeling 3DP Technology

Fabrication and Characterization of Flexible Medical-Grade TPU Filament for Fused Deposition Modeling 3DP Technology

Biobased polyurethanes for biomedical applications

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