Polyvalent Bacteriophages and Oxygenated Water – Possibilities for Prevention of Surgical Site Infection During Emergency Abdominal Surgery

Abstract

We carried out a single-center study of the effectiveness of polyvalent bacteriophages and oxygenated water for the prevention of SSI. The object was 88 patients who had undergone abdominal surgery for emergency abdominal pathology with a high risk of SSI >30±3% (ACS NSQIP). Phages were administered topically and enterally, while OW only enterally. As a result of the study, it turned out that the combined use of PVBP and OW allows to normalize the induced enteral pathobiome, to reduce pathogen contamination, to enhance the protective capabilities of enterocytes, to stop intestinal failure in the early stages and to reduce the risk of SSI by more than 2 times.