Polyvinyl alcohol gel prevents abdominal adhesion formation in a rabbit model

Lang, R. A.; Grüntzig, Patricia Mercedes; C, Weisgerber; Weis, Christine; Odermatt, Erich K.; Kirschner, Martin

doi:10.1016/j.fertnstert.2007.01.108

Cited by 32 publications

(30 citation statements)

References 33 publications

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“…The physically cross-linked polyvinyl alcohol (PVA) and carboxymethylcellulose (CMC) (PVA/CMC, A-Part®; B. Braun Aesculap, AG, Tuttlingen, Germany) hydrogel is a new physical barrier which can be applied at the end of the operation on the viscera. In few earlier animal studies with this gel a significant adhesion reduction effect was found; however, more data were necessary to confirm the antiadhesive properties of this product [7,8,9]. In the present study, PVA/CMC gel is compared to icodextrin 4% (Adept®; Baxter USA), which is one of the most used antiadhesive agents in abdominal surgery with level I evidence for an antiadhesive effect following gynecological operations [10].…”

Section: Introductionmentioning

confidence: 84%

“…In order to find an effective and feasible adhesion prevention agent, a new adhesion prevention barrier based on PVA was developed [7]. The results were very promising; however, the gel appeared to slip away from the trauma site too easily.…”

Section: Discussionmentioning

confidence: 99%

“…To improve the quality of adherence to the abdominal wall, CMC was added resulting in PVA/CMC gel [9]. In the first experimental studies the new hydrogel seemed to be a feasible and effective adhesion prevention agent, although still few data are available [7,8,9]. …”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Postoperative Adhesion Prevention with a New Barrier: An Experimental Study

Ditzel

Deerenberg²,

Komen³

et al. 2012

Eur Surg Res

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Introduction: Postoperative adhesion formation remains a major clinical problem. The aim of this study was to test the effect of a new hydrogel on adhesion formation in a rat model. Materials and Methods: A reproducible rat model was used to induce standardized adhesion formation in three experiments. In experiment 1, a cross-linked polyvinyl alcohol (PVA) and carboxymethylcellulose (CMC) hydrogel (PVA/CMC, A-Part®; B. Braun Aesculap, Germany) was tested in different dosages. In experiment 2, PVA/CMC gel was compared to icodextrin 4% (Adept®; Baxter USA). In both groups, animals were sacrificed after 2 weeks. In experiment 3, histological examination after 4 and 6 weeks was performed. The percentage of adhesions to the defect was measured and the density was determined according to the Zühlke scale. During histological examination of the abdominal wall, the formation of neoperitoneum and potential residues of the agents were assessed. Results: In experiment 1, a significant reduction in amount as well as density of the adhesions was visible with all dosages of PVA/CMC gel. In experiment 2, again quantity and density of the adhesions were diminished by PVA/CMC hydrogel compared to the control group. Icodextrin 4% showed no significant reduction in adhesion formation. In experiment 3, no residues of PVA/CMC gel or icodextrin 4% were found during histological examination after 4 and 6 weeks and neoperitoneum was present in all cases. Conclusion: PVA/CMC hydrogel appears to be a novel effective adhesion prevention agent. Together with an upcoming safety study, these data encourage to start clinical efficacy studies.

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Section: Introductionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Postoperative Adhesion Prevention with a New Barrier: An Experimental Study

Ditzel

Deerenberg²,

Komen³

et al. 2012

Eur Surg Res

View full text Add to dashboard Cite

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“…Adezyonu azalttığını belirten çalışmalar olduğu gibi başarısız olduğunu belirten çalışmalarda mevcuttur. [2][3][4][5][6] Müller ve arkadaşlarının [21] yaptığı ça-lışmada ise peritonitli olgularda yapışıklığı azaltmadı-ğı gibi daha sık apse gelişimine neden olduğu bildirilmiştir. Çalışmamızda ise sonuçlar değerlendirildiğinde ikodekstrinin yapışıklık oluşumunu belirgin olarak azalttığı saptandı.…”

Section: Discussionunclassified

“…[1] Adezyon önleyici ajan olarak kullanılan %4'lük ikodekstrin solüsyonunun adezyonu önlemede etkin olduğunu belirten çalışmalar olduğu gibi aksi yönde görüş bildiren çalışmalar da vardır. [2][3][4][5][6] Gastrointestinal sistem anastomozları üzerine etkisi konusunda ise literatürde üç adet deneysel çalışmaya ulaşılmıştır. [7][8][9] Çalışmaların ikisinde anastomoz iyileşmesini olumsuz yönde etkilemediği belirtilirken bir tanesinde aksi yönde görüş bildirilmiştir.…”

Section: Bulgularunclassified

Effects of abdominal adhesion-preventing 4% icodextrin solution on healing of bowel anastomoses

Koç¹,

Dağ²,

Öcal³

et al. 2013

Ulus Travma Acil Cerrahi Derg

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Uniaxial tensile and structural properties of poly(vinyl alcohol) films: The influence of heating and film thickness

Aksakal

Yargı

Şahintürk

2017

J of Applied Polymer Sci

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Poly(vinyl alcohol) as pure or composite materials is widely used in the food and textile industries, andbiomedical applications due to some important properties such as uniaxial tensile, biocompatibility, and noncarcinogenicity. Investigation of the influence of the film thickness and heating on the uniaxial tensile, spectroscopic, and surface properties of PVA films investigated in this study is quite important for improving the properties of such materials and their applicability in different conditions. In this study, with the influence of heating, a necking behavior was observed at around 2% for thin films and 4-9% strain for thicker PVA films for which a kind of transition point at around 1-2% strain was observed. The mechanical strength of PVA films, strain at break, and Young's modulus were enhanced greatly as the temperature increased from 80 to around 110 8C, and then most of them decreased. The degree of crystallinity increased linearly with the heat temperature from around 36-40%. Although PVA thin films obtained a very smooth surface structure after being heated at 80 8C, with increasing heat temperature, the surface roughness of both thin and thick PVA films increased and the PVA thin films obtained more degraded film surface. V C 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44915.

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Polyvinyl alcohol gel prevents abdominal adhesion formation in a rabbit model

Cited by 32 publications

References 33 publications

Postoperative Adhesion Prevention with a New Barrier: An Experimental Study

Postoperative Adhesion Prevention with a New Barrier: An Experimental Study

Effects of abdominal adhesion-preventing 4% icodextrin solution on healing of bowel anastomoses

Uniaxial tensile and structural properties of poly(vinyl alcohol) films: The influence of heating and film thickness

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